scholarly journals Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury

2017 ◽  
Vol 187 (8) ◽  
pp. 1772-1786 ◽  
Author(s):  
Jazalle McClendon ◽  
Nicole L. Jansing ◽  
Elizabeth F. Redente ◽  
Aneta Gandjeva ◽  
Yoko Ito ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Hypoxia Inducible Factor ◽  
Alveolar Epithelium ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Inhibition of hypoxia inducible factor-1α ameliorates lung injury induced by trauma and hemorrhagic shock in rats

2012 ◽  
Vol 33 (5) ◽  
pp. 635-643 ◽  
Author(s):  
Hong Jiang ◽  
Yan Huang ◽  
Hui Xu ◽  
Rong Hu ◽  
Qi-fang Li
Keyword(s):  
Lung Injury ◽  
Hemorrhagic Shock ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Alveolar epithelium and Na,K-ATPase in acute lung injury

2007 ◽  
Vol 33 (7) ◽  
pp. 1243-1251 ◽  
Author(s):  
István Vadász ◽  
Stacy Raviv ◽  
Jacob I. Sznajder
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Alveolar Epithelium

scholarly journals Endothelial Hypoxia-Inducible Factor-1α Is Required for Vascular Repair and Resolution of Inflammatory Lung Injury through Forkhead Box Protein M1

2019 ◽  
Vol 189 (8) ◽  
pp. 1664-1679 ◽  
Author(s):  
Xiaojia Huang ◽  
Xianming Zhang ◽  
David X. Zhao ◽  
Jun Yin ◽  
Guochang Hu ◽  
...  
Keyword(s):  
Lung Injury ◽  
Hypoxia Inducible Factor ◽  
Vascular Repair ◽  
Hypoxia Inducible Factor 1Α ◽  
Forkhead Box

Hypoxia-inducible factor prolyl-hydroxylase inhibitor roxadustat (FG-4592) alleviates sepsis-induced acute lung injury

2020 ◽  
Vol 281 ◽  
pp. 103506
Author(s):  
Fu Han ◽  
Gaofeng Wu ◽  
Shichao Han ◽  
Zhenzhen Li ◽  
Yanhui Jia ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Hypoxia Inducible Factor ◽  
Prolyl Hydroxylase ◽  
Prolyl Hydroxylase Inhibitor

scholarly journals Animal models of acute lung injury

2008 ◽  
Vol 295 (3) ◽  
pp. L379-L399 ◽  
Author(s):  
Gustavo Matute-Bello ◽  
Charles W. Frevert ◽  
Thomas R. Martin
Keyword(s):  
Risk Factors ◽  
Acute Lung Injury ◽  
Animal Models ◽  
Lung Injury ◽  
Animal Studies ◽  
Ischemia Reperfusion ◽  
Alveolar Epithelium ◽  
Acid Aspiration ◽  
Advantages And Disadvantages ◽  
Clinical Risks

Acute lung injury in humans is characterized histopathologically by neutrophilic alveolitis, injury of the alveolar epithelium and endothelium, hyaline membrane formation, and microvascular thrombi. Different animal models of experimental lung injury have been used to investigate mechanisms of lung injury. Most are based on reproducing in animals known risk factors for ARDS, such as sepsis, lipid embolism secondary to bone fracture, acid aspiration, ischemia-reperfusion of pulmonary or distal vascular beds, and other clinical risks. However, none of these models fully reproduces the features of human lung injury. The goal of this review is to summarize the strengths and weaknesses of existing models of lung injury. We review the specific features of human ARDS that should be modeled in experimental lung injury and then discuss specific characteristics of animal species that may affect the pulmonary host response to noxious stimuli. We emphasize those models of lung injury that are based on reproducing risk factors for human ARDS in animals and discuss the advantages and disadvantages of each model and the extent to which each model reproduces human ARDS. The present review will help guide investigators in the design and interpretation of animal studies of acute lung injury.

scholarly journals Acute Cobalt-Induced Lung Injury and the Role of Hypoxia-Inducible Factor 1α in Modulating Inflammation

2010 ◽  
Vol 116 (2) ◽  
pp. 673-681 ◽  
Author(s):  
Yogesh Saini ◽  
Krista K. Greenwood ◽  
Christian Merrill ◽  
Kyung Y. Kim ◽  
Sonika Patial ◽  
...  
Keyword(s):  
Lung Injury ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1Α
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