Alcohol related phenotypes and platelet serotonin concentration

Objective Impaired serotonergic neurotransmission has been implicated in the pathogenesis of depression and schizophrenia. Blood platelets have been used for years as a peripheral model of neuronal serotonin dynamics. The objective was to investigate platelet count and serotonin concentration in patients with depression and schizophrenia, in an attempt to ascertain their clinical usefulness.Methods 953 participants were included in the study, 329 patients with depression, 339 patients with schizophrenia and 285 healthy controls. ELISA was used to assess platelet serotonin concentrations.Results There were no statistically significant differences among groups regarding age, total platelet count and serotonin concentration. Linear regression analyses revealed inverse correlations between platelet serotonin concentration and age of patients with depression and healthy individuals, as well as between platelet serotonin concentration and illness duration in patients with schizophrenia. In other words, longer illness duration in patients with schizophrenia, and higher age in patients with depression and healthy individuals was associated with lower platelet serotonin concentrations.Conclusion Platelet count and serotonin concentration did not prove to be of diagnostic value in differentiating patients and healthy individuals. However, illness duration in patients with schizophrenia may be associated with reduced concentrations of platelet serotonin.

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Assessment of Platelet and Plasma Serotonin in Canine Pulmonary Hypertension Secondary to Degenerative Mitral Valve Disease

Frontiers in Veterinary Science ◽

10.3389/fvets.2021.695492 ◽

2021 ◽

Vol 8 ◽

Author(s):

Nattawan Tangmahakul ◽

Pussadee Makoom ◽

Sirilak Disatian Surachetpong

Keyword(s):

Pulmonary Hypertension ◽

Mitral Valve ◽

Mitral Valve Disease ◽

High Probability ◽

Valve Disease ◽

Serotonin Concentration ◽

Platelet Serotonin ◽

The Difference ◽

Post Hoc ◽

Plasma Serotonin

Background: Pulmonary hypertension (PH) is a common complication of degenerative mitral valve disease (DMVD), the most common cardiovascular disease in dogs. Serotonin has been suspected to play a role in the pathogenesis of PH, so this study aimed to investigate the differences in platelet and plasma serotonin between normal, DMVD and DMVD with PH (DMVD+PH) dogs.Materials and Methods: Sixty-two small-breed dogs were enrolled to the study and divided into the normal (n = 22), DMVD (n = 20), and DMVD+PH (n = 20) groups. The platelet and plasma serotonin concentrations were measured by the competitive ELISA.Results: The Kruskal–Wallis revealed the difference among the four groups of normal (179.73 [102.37–352.24] ng/109 platelets), DMVD (325.99 [96.84–407.66] ng/109 platelets), DMVD with intermediate probability of PH (291.11 [106.69–400.84] ng/109 platelets) and DMVD with high probability of PH (35.82 [2.69–126.35] ng/109 platelets) (p = 0.014). The Dunn's post-hoc test showed a decrease in the platelet serotonin concentration of the DMVD dogs with high probability of PH compared to the DMVD group (p = 0.008). The plasma serotonin concentration was not different between normal, DMVD, and DMVD+PH dogs.Conclusion: In conclusion, a decrease in platelet serotonin concentration, which is associated with a degree of PH probability was found in DMVD dogs with PH. Further studies investigating roles of platelet serotonin in PH secondary to DMVD should be performed.

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Platelet serotonin concentration and suicidal behavior in combat related posttraumatic stress disorder

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2007.10.014 ◽

2008 ◽

Vol 32 (2) ◽

pp. 544-551 ◽

Cited By ~ 31

Author(s):

Zrnka Kovacic ◽

Neven Henigsberg ◽

Nela Pivac ◽

Gordana Nedic ◽

Andrea Borovecki

Keyword(s):

Posttraumatic Stress Disorder ◽

Posttraumatic Stress ◽

Suicidal Behavior ◽

Stress Disorder ◽

Serotonin Concentration ◽

Platelet Serotonin

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Urinary serotonin in the diagnosis of carcinoid tumors.

Clinical Chemistry ◽

10.1093/clinchem/32.5.840 ◽

1986 ◽

Vol 32 (5) ◽

pp. 840-844 ◽

Cited By ~ 78

Author(s):

J M Feldman

Keyword(s):

Carcinoid Tumor ◽

Normal Subjects ◽

Carcinoid Tumors ◽

Serotonin Concentration ◽

Complementary Information ◽

Normal Platelet ◽

Platelet Serotonin ◽

Hydroxyindoleacetic Acid

Abstract To determine whether measurement of serotonin in urine would give useful complementary information to the usual measurement of 5-hydroxyindoleacetic acid (5-HIAA) in urine and platelet serotonin in platelets, I measured these analytes in 75 consecutive patients with carcinoid tumors, and found that 75% had above-normal urinary 5-HIAA excretion, 64% had above-normal serotonin excretion, and 64% had above-normal platelet serotonin concentration. Six patients had increased urinary serotonin, but 5-HIAA excretion and platelet serotonin concentration were normal. Only two of a further 50 patients with solid noncarcinoid tumors--and none of 55 patients with flushing or diarrhea, who did not prove to have a carcinoid tumor--had increased urinary serotonin. Ingestion of four bananas (a food rich in serotonin) increased urinary 5-HIAA but not urinary serotonin excretion of seven normal subjects. Evidently, measurement of urinary serotonin excretion is helpful in the evaluation of patients with suspected carcinoid tumors.

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