Overdose with medications is a common method of suicide. Reviews of suicide prevention strategies confirmed that restricting access to lethal means is effective in preventing suicides. Nevertheless, there have not been any randomized controlled trials, proving that restriction of the access to toxic medications decreases suicide rates. Existing evidence is based mainly on observational, ecological, and cohort studies. Factors such as better mental health conditions, effective treatment of depression, and improvement in socioeconomic status, may also contribute to decreasing suicide rates. Restrictive measures will have a large effect if the respective method is frequent and lethal. Although there are some concerns about substitution of suicide methods if access to a specific drug is restricted, many studies suggest a life-saving potential. Restrictive measures represent an effective and feasible public health strategy for suicide prevention, particularly in individuals that carry out briefly planned impulsive acts, and in combination with other interventions.