scholarly journals The effect of a regular exercise program in the control of blood pressure and plasma glucose levels in tipe II sedentary diabetic patients

2004 ◽  
Vol 17 (5) ◽  
pp. S217
Author(s):  
A DAMASCENO
Keyword(s):  
Blood Pressure ◽  
Plasma Glucose ◽  
Exercise Program ◽  
Diabetic Patients ◽  
Regular Exercise ◽  
Glucose Levels

THE EFFECT OF A REGULAR EXERCISE PROGRAM IN THE CONTROL OF BLOOD PRESSURE AND GLUCOSE IN TYPE II SEDENTARY DIABETIC PATIENTS

2004 ◽  
Vol 22 (Suppl. 1) ◽  
pp. S98-S99
Author(s):  
A Damasceno ◽  
A Prista ◽  
P Caupers ◽  
B Chemane ◽  
B Fernhaall ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Exercise Program ◽  
Diabetic Patients ◽  
Regular Exercise ◽  
Type Ii

scholarly journals Body Mass Index, Fasting Plasma Glucose Levels, and C-peptide Levels as Predictors of the Future Insulin Use in Japanese Type 2 Diabetic Patients

2010 ◽  
Vol 57 (3) ◽  
pp. 237-244 ◽  
Author(s):  
Atsushi GOTO ◽  
Maki TAKAICHI ◽  
Miyako KISHIMOTO ◽  
Yoshihiko TAKAHASHI ◽  
Hiroshi KAJIO ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Glucose Levels ◽  
Insulin Use ◽  
Type 2 Diabetic

Segmentation and Pattern Analyses for Three Meals of Postprandial Plasma Glucose Values and Associated Carbs/Sugar Amounts Using GH-Method: Math-Physical Medicine (No. 326)

2020 ◽  
Vol 2 (2) ◽  
pp. 1-4
Author(s):  
Gerald C Hsu ◽  
Keyword(s):  
Plasma Glucose ◽  
Research Work ◽  
Exercise Program ◽  
Management Program ◽  
Conversion Ratio ◽  
Lifestyle Management ◽  
Postprandial Plasma Glucose ◽  
Sugar Intake ◽  
Glucose Levels ◽  
Segmentation Analysis

The author describes the results of segmentation and pattern analyses of postprandial plasma glucose levels (PPG) and carbs/sugar intake amount (carbs), which are associated with his three daily meals. In this paper, there are three consistent ranges of low, medium, and high for PPG values and carbs/sugar amounts that are used for each meal but with different units. One of the final objectives for this analysis is to calculate the most reasonable and effective conversion ratio between measured PPG in mg/dL and carbs/sugar intake amount in grams, by discovering how much PPG amount would be generated from 1 gram of carbs/sugar intake. This investigation utilized the PPG data and carbs/sugar amount collected during a period of 2+ years from 5/5/2018 to 9/6/2020 with a breakdown of 855 days, including 2,565 meals, 33,345 glucose data, and 33,345 carbs/sugar data. By using the segmentation analysis of his 33,345 PPG data and 2,565 carbs/sugar data, the author has conducted a pattern recognition and segmentation analysis from his PPG profiles with its associated carbs/sugar intake of his food and meals in the past 855 days. Since 12/8/2015, he ceased taking any diabetes medications. In other words, his diabetes control is 100% dependent on his lifestyle management program with no chemical intervention from any medications. Subsequently, he has maintained a stringent exercise program after each meal; therefore, the development of his simplified PPG prediction model, excluding the exercise factor, can be expressed solely with carbs/sugar intake amount. Predicted PPG = (baseline glucose) + (conversion ratio * carbs/sugar amount) In his research work, he found the reasonable and effective conversion ratio between PPG and carbs that ranges from 1.8 mg/dL per gram to 2.5 mg/dL per gram. This simple equation could assist many type 2 diabetes (T2D) patients in controlling their diabetes via carbs/sugar intake amount. During this particular time period, his PPG control via a stringent lifestyle management without medication is highly successful. His estimated mathematically derived HbA1C values should be between 5.56% to 6.05%, which is a satisfactory HbA1C level for a 73-year-old male with a 25-year history of severe diabetes. It should be mentioned that he had an average daily glucose of 280 mg/dL and HbA1C of 11% in 2010. This segmented pattern analyses based on his PPG data and carbs/sugar intake amount offer a useful tool for analyzing other types of biomarkers in a deeper investigation with a wider entry point of research.

scholarly journals Leptin G-2548A Gene Polymorphism is Positively Associated with Increased Plasma Leptin and Glucose Levels in Obese Saudi Patients Irrespective Status of Blood Pressure    

2021 ◽  
Author(s):  
Lotfi S. Bin Dahman ◽  
Nasser M. Al-Daghri
Keyword(s):  
Blood Pressure ◽  
Gene Polymorphism ◽  
Plasma Glucose ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Lep Gene ◽  
Plasma Leptin ◽  
Saudi Patients

Abstract The association between LEP G-2548A gene polymorphism with increased plasma leptin and glucose levels and blood pressure in a sample of obese Saudi patients has been evaluated. This is a cross-sectional study involved 206 Saudi adult subjects (94 males and 112 females), randomly selected from the primary health care centers, Riyadh, Saudi Arabia. The study sample was categorized into three groups: 50 normotensive ND controls (age: 47.9±5.4 yr.; BMI 22.9±2.1 Kg/m2), 80 obese normotensive ND (age: 47.7±6.0 yr.; BMI 34.1±4.2 Kg/m2) and 76 obese hypertensive with T2D patients (age: 49.4±5.9 yr.; BMI: 35.1±4.7 Kg/m2). Analyses of LEP G-2548A gene polymorphism were determined using polymerase chain reaction (PCR), followed by restriction fragment length polymorphism (RFLP) with 2U of HhaI restriction enzyme. Plasma leptin and insulin levels were measured using the Luminex instrument. Fasting plasma glucose, total cholesterol, HDL-cholesterol, and triglycerides were measured using a chemical autoanalyzer Konelab machine. Also, blood pressure and anthropometric data were measured. The association analysis with metabolic parameters showed that homozygous AA of the LEP gene had significantly higher plasma glucose levels and HOMA-IR compared with homozygous GG (6.8±0.55 vs. 5.8±0.30; p< 0.04; 4.1±0.84 vs. 2.6±0.67; p=0.03) respectively. Besides, heterozygous GA had significantly higher plasma leptin levels compared with homozygous GG (40.0±2.6 vs. 29.6±2.6; P= 0.04). GA, AA, GA+AA genotypes of the LEP G-2548A gene polymorphism are more prevalent among individuals with hyperglycemia (OR= 3.7, 95% CI= 1.6 to 8.4, P= 0.001; OR= 3.2, 95% CI= 1.2 to 8.6, P= 0.03; OR= 3.5, 95%CI= 1.6 to 7.7, P= 0.001) respectively. A allele of the LEP gene is more prevalent among subjects with hyperglycemia (OR= 1.9, 95%CI= 1.2 to 3.0, P=0.006). G-2548A variant of the LEP gene may not be considered as a genetic risk factor for hypertension in Saudi obese patients. However, the genotypes (GA and AA) and -2548AA allele of this gene may represent important risk factors predisposing healthy subjects to develop T2DM irrespective of the status of blood pressure.

scholarly journals MON-LB043 A Case of Renovascular Hypertension With Cortisol-Producing Adrenal Masses

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Takuya Higashitani ◽  
Daisuke Aono ◽  
Mitsuhiro Kometani ◽  
Shigehiro Karashima ◽  
Masashi Demura ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Renal Artery ◽  
Renovascular Hypertension ◽  
Plasma Glucose ◽  
Left Renal Artery ◽  
Glucose Levels ◽  
Computed Tomography Scanning ◽  
Old Japanese ◽  
Adrenal Masses

Abstract Renovascular hypertension (RVHT) is an important and potentially treatable form of resistant hypertension. Hypercortisolemia could also cause hypertension and diabetes mellitus. We experienced a case wherein adrenalectomy markedly improved blood pressure and plasma glucose levels in a patient with RVHT and subclinical Cushing’s syndrome. A 62-year-old Japanese man had been treated for hypertension and diabetes mellitus for 10 years. He was hospitalized because of disturbance in consciousness. His blood pressure (BP) was 236/118 mmHg; pulse rate, 132 beats/min; and plasma glucose level, 712 mg/dl. Abdominal computed tomography scanning revealed the presence of bilateral adrenal masses and left atrophic kidney. Abdominal magnetic resonance angiography demonstrated marked stenosis of the left main renal artery. The patient was subsequently diagnosed with atherosclerotic RVHT with left renal artery stenosis. Bilateral adrenal masses were immunohistologically identified as potential sites for cortisol overproduction. Therefore, laparoscopic left nephrectomy and adrenalectomy were simultaneously performed resulting in improved BP and glucose levels. Pathological studies revealed the presence of multiple cortisol-producing adrenal nodules and aldosterone-producing cell clusters in the adjacent left adrenal cortex. In the present case, activated renin-angiotensin-aldosterone system and cortisol overproduction resulted in severe hypertension, which was managed with simultaneous unilateral nephrectomy and adrenalectomy.

scholarly journals Leptin G-2548A Gene Polymorphism is Positively Associated with Increased Plasma Leptin and Glucose Levels in Obese Saudi Patients Irrespective Status of Blood Pressure    

2021 ◽  
Author(s):  
Lotfi S. Bin Dahman ◽  
Nasser M. Al-Daghri
Keyword(s):  
Blood Pressure ◽  
Gene Polymorphism ◽  
Plasma Glucose ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Lep Gene ◽  
Plasma Leptin ◽  
Saudi Patients

Abstract The association between LEP G-2548A gene polymorphism with increased plasma leptin and glucose levels and blood pressure in a sample of obese Saudi patients has been evaluated. This is a cross-sectional study involved 206 Saudi adult subjects (94 males and 112 females), randomly selected from the primary health care centers, Riyadh, Saudi Arabia. The study sample was categorized into three groups: 50 normotensive ND controls (age: 47.9±5.4 yr.; BMI 22.9±2.1 Kg/m2), 80 obese normotensive ND (age: 47.7±6.0 yr.; BMI 34.1±4.2 Kg/m2) and 76 obese hypertensive with T2D patients (age: 49.4±5.9 yr.; BMI: 35.1±4.7 Kg/m2). Analyses of LEP G-2548A gene polymorphism were determined using polymerase chain reaction (PCR), followed by restriction fragment length polymorphism (RFLP) with 2U of HhaI restriction enzyme. Plasma leptin and insulin levels were measured using the Luminex instrument. Fasting plasma glucose, total cholesterol, HDL-cholesterol, and triglycerides were measured using a chemical autoanalyzer Konelab machine. Also, blood pressure and anthropometric data were measured. The association analysis with metabolic parameters showed that homozygous AA of the LEP gene had significantly higher plasma glucose levels and HOMA-IR compared with homozygous GG (6.8±0.55 vs. 5.8±0.30; p< 0.04; 4.1±0.84 vs. 2.6±0.67; p=0.03) respectively. Besides, heterozygous GA had significantly higher plasma leptin levels compared with homozygous GG (40.0±2.6 vs. 29.6±2.6; P= 0.04). GA, AA, GA+AA genotypes of the LEP G-2548A gene polymorphism are more prevalent among individuals with hyperglycemia (OR= 3.7, 95% CI= 1.6 to 8.4, P= 0.001; OR= 3.2, 95% CI= 1.2 to 8.6, P= 0.03; OR= 3.5, 95%CI= 1.6 to 7.7, P= 0.001) respectively. A allele of the LEP gene is more prevalent among subjects with hyperglycemia (OR= 1.9, 95%CI= 1.2 to 3.0, P=0.006). G-2548A variant of the LEP gene may not be considered as a genetic risk factor for hypertension in Saudi obese patients. However, the genotypes (GA and AA) and -2548AA allele of this gene may represent important risk factors predisposing healthy subjects to develop T2DM irrespective of the status of blood pressure.

scholarly journals Seasonal changes in the cardiovascular, respiratory and metabolic responses to temperature and hypoxia in the bullfrog rana catesbeiana

1998 ◽  
Vol 201 (5) ◽  
pp. 761-768 ◽  
Author(s):  
P L Rocha ◽  
L G S Branco
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Body Temperature ◽  
Arterial Blood Pressure ◽  
Plasma Glucose ◽  
Rana Catesbeiana ◽  
Breathing Frequency ◽  
Glucose Levels ◽  
Arterial Blood ◽  
The Difference

We assessed seasonal variations in the effects of temperature on hypoxia-induced alterations in the bullfrog Rana catesbeiana by measuring the heart rate, arterial blood pressure, breathing frequency, metabolic rate, blood gas levels, acid-base status and plasma glucose concentration. Regardless of the season, decreased body temperature was accompanied by a reduction in heart and breathing frequencies. Lower temperatures caused a significant decrease in arterial blood pressure during all four seasons. Hypoxia-induced changes in breathing frequency were proportional to body temperature and were more pronounced during winter, less so during spring and autumn and even smaller during summer. Season had no effect on the relationship between hypoxia and heart rate. At any temperature tested, the rate of oxygen consumption had a tendency to be highest during summer and lowest during winter, but the difference was significant only at 35 degrees C. The PaO2 and pH values showed no significant change during the year, but PaCO2 was almost twice as high during winter than in summer and spring, indicating increased plasma bicarbonate levels. Lower temperatures were accompanied by decreased plasma glucose levels, and this effect was greater during summer and smaller during autumn. Hypoxia-induced hyperglycaemia was influenced by temperature and season. During autumn and winter, plasma glucose level remained elevated regardless of temperature, probably to avoid dehydration and/or freezing. In winter, the bullfrog may be exposed not only to low temperatures but also to hypoxia. These animals show temperature-dependent responses that may be beneficial since at low body temperatures the set-points of most physiological responses to hypoxia are reduced, regardless of the season. &lt;P&gt;

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