The prevalence and correlation between subclinical hypothyroidism and gall stone disease in Baghdad teaching hospital

Background: Contribution of hypothyroidism to gallstone formation is debated over years. With this background, the study intended to analyze the prevalence of undiagnosed hypothyroidism in patients with cholelithiasis. The aim is to understand the prevalence of hypothyroidism in patients with gallstones.Methods: A prospective, hospital-based study was done on 100 patients admitted for the management of gall stone disease in Belagavi. After initial screening, a detailed history was obtained with special reference to symptomatology and the risk factors as per proforma from patients meeting selection criteria. Thyroid function test was done on all eligible patients. Patients were divided into three groups of Euthyroid, Subclinical hypothyroid and clinical hypothyroidism. Statistical analysis used. Percentage of gall stones in different age groups and gender of the study population was calculated followed by prevalence of hypothyroidism and subclinical hypothyroidism in all the patients included.Results: Among the study population, 40% were male and 60% were female. 23 of them have subclinical hypothyroidism and 6 of them were diagnosed with hypothyroidism. Majority of subclinical hypothyroid patients (39.13%) were aged 41-60 years. Hypothyroid symptoms were shown by the study population with unknown thyroid status.Conclusions: The prevalence of hypothyroidism in cholelithiasis is 29% in the study and is significant. The study demands further studies to consider hypothyroidism as a cause /risk factor for biliary calculus.

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Prevalence of subclinical hypothyroidism in diagnosed cases of gall stone disease: Prospective study from a tertiary care institute in Himalayan region

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v8i4.08 ◽

2020 ◽

Vol 08 (04) ◽

Author(s):

Dr Mahender Singh Rana ◽

Keyword(s):

Prospective Study ◽

Subclinical Hypothyroidism ◽

Tertiary Care ◽

Gall Stone ◽

Stone Disease ◽

Himalayan Region ◽

Care Institute ◽

Gall Stone Disease

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The Prevalence and Association between Subclinical Hypothyroidism and Gall Stone Disease: Study in Shaheed Suhrawardy Medical College Hospital

Journal of Shaheed Suhrawardy Medical College ◽

10.3329/jssmc.v11i2.48964 ◽

2020 ◽

Vol 11 (2) ◽

pp. 130-133

Author(s):

Nadim Ahmed ◽

ABM Muksudul Alam ◽

Shoaeb Imtiaz Alam ◽

Sami Ahmad ◽

Rafiqul Karim Khan ◽

...

Keyword(s):

Subclinical Hypothyroidism ◽

Stone Formation ◽

Gall Stone ◽

Thyroid Function Test ◽

Stone Disease ◽

College Hospital ◽

Cross Sectional ◽

Gall Stones ◽

Number Of Patients ◽

Gall Stone Disease

Background: Gall stones are the most common biliary pathology. Subclinical hypothyroidism is not an uncommon problem in the population with thyroid disease, several explanations for a possible relation between hypothyroidism and lipid metabolism with gall stone formation proved that prevalence of gall stones is increased in patients with hypothyroidism. Objective: To find the prevalence and correlation between the subclinical hypothyroidism and gall stone disease. Methods: This is a cross-sectional study was done in the Unit-II of department of Surgery of Shaheed Suhrawardy Medical Hospital between July 2018 to June 2019, where 80 patients presented with gall stones. All the patients were assessed and prepared for cholecystectomy by detailed history, clinical examination, thyroid function test, abdominal ultrasound and others investigation needed for general anaesthesia. Results: Among 80 patients, 78.57% were in 40–59 year age group, 56 (70%) of them were female and 24 (30%) were male. Of the total number of patients, 14 of them (17.5%) had subclinical hypothyroidism and 66 (82.5%) were euthyroid. Most of patients in the subclinical hypothyroid group were showing female gender predominance with 78.57%. While the prevalence among males were found 21.43%. Dyslipidemia was present among 81.25% patients (p=0.03) having subclinical hypothyroidism and gall stones. Besides single stone was common (57.14%) among this hypothyroid group and all stones of this group were >1 cm. Conclusion: There is a gender speciûc relationship between subclinical hypothyroidism and gall stone disease. As this study sharing statistically significant in the prevalence of the subclinical hypothyroidism among females in age groupe³40 years, dyslipidemia and single gall stone. This subset of patients should be assessed for thyroid dysfunction. J Shaheed Suhrawardy Med Coll, December 2019, Vol.11(2); 130-133

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Investigation of the Lith1 candidate genes ABCB11 and LXRA in human gall stone disease

Zeitschrift für Gastroenterologie ◽

10.1055/s-2006-950845 ◽

2006 ◽

Vol 44 (08) ◽

Author(s):

C Schafmayer ◽

J Tepel ◽

JH Egberts ◽

A Franke ◽

S Buch ◽

...

Keyword(s):

Candidate Genes ◽

Gall Stone ◽

Stone Disease ◽

Gall Stone Disease

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Early experience of laparoscopic cholecystectomy in acutely inflamed gallbladder

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v9ispl1.1283 ◽

2018 ◽

Vol 9 (SPL1) ◽

Author(s):

Ali Abdul Hussein Handoz ◽

Ahmed Kh Alsagban

Keyword(s):

Laparoscopic Cholecystectomy ◽

Acute Cholecystitis ◽

Gall Stone ◽

The Elderly ◽

Stone Disease ◽

Definitive Treatment ◽

Adjacent Structures ◽

Common Causes ◽

Gall Stone Disease ◽

Male To Female

Gallstones are now among the most important disease in the era of surgery. Definitive treatment of gall stone disease remains cholecystectomy. One of the common causes of emergency surgical referral is acute cholecystitis of which 50-70% cases are seen in the elderly patients.50 patients were treated with laparoscopic cholecystectomy from October 2013 to October 2015. The patient’s age was from 20 to 65 years old with a mean age of 34 ±3 years old. The patients received in the emergency unit and their attack not more than 72 hrs of acute gall stone inflammation were included in this study.From the 50 patients,15 were males (34%) and females were 35 (74%) so the ratio of 1:2of male to female. Problems and complications that facing in this study at time of laparoscopy were mainly adhesions to the adjacent structures like stomach, colon, and omentum. Adhesion into CBD also considered.Early intervention for acute cholecystitis of calculus type by laparoscopy now regarding safe and gold standard approach that should be kept in mind when dealing with such cases.

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