Recurrent immediate hypersensitivity reaction to radiocontrast media despite premedication found to be IgE-mediated

This study was carried out to examine the effect of an aqueous extract from Siegesbeckia pubescens (Compositae) (SPAE) on immunoglobulin E (IgE)-mediated immediate hypersensitivity reaction. Forty-eight hours passive cutaneous anaphylaxis in rats was significantly inhibited by oral administration of SPAE (100 μg/g). It also inhibited histamine release from rat peritoneal mast cells induced by anti-dinitrophenyl (DNP)-IgE and DNP-human serum albumin. The data indicate that SPAE has antiallergic activity, and that its action may be due to inhibition of histamine release from mast cells.

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Comparison of immediate hypersensitivity reaction rate according to the type of radiocontrast media

Asian Pacific Journal of Allergy and Immunology ◽

10.12932/ap-191017-0182 ◽

2018 ◽

Keyword(s):

Hypersensitivity Reaction ◽

Reaction Rate ◽

Immediate Hypersensitivity ◽

Radiocontrast Media

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Autonomous regulation of IgE-mediated mast cell degranulation and immediate hypersensitivity reaction by an inhibitory receptor CD300a

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2019.03.005 ◽

2019 ◽

Vol 144 (1) ◽

pp. 323-327.e7 ◽

Cited By ~ 2

Author(s):

Yaqiu Wang ◽

Chigusa Nakahashi-Oda ◽

Yoshimichi Okayama ◽

Akira Shibuya

Keyword(s):

Mast Cell ◽

Hypersensitivity Reaction ◽

Mast Cell Degranulation ◽

Inhibitory Receptor ◽

Immediate Hypersensitivity ◽

Autonomous Regulation ◽

Ige Mediated

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The diagnostic value of basophil activation test in patients with an immediate hypersensitivity reaction to radiocontrast media

Annals of Allergy Asthma & Immunology ◽

10.1016/j.anai.2010.12.020 ◽

2011 ◽

Vol 106 (5) ◽

pp. 387-393 ◽

Cited By ~ 34

Author(s):

Panwas Pinnobphun ◽

Supranee Buranapraditkun ◽

Thatchai Kampitak ◽

Nattiya Hirankarn ◽

Jettanong Klaewsongkram

Keyword(s):

Hypersensitivity Reaction ◽

Basophil Activation Test ◽

Diagnostic Value ◽

Basophil Activation ◽

Immediate Hypersensitivity ◽

Activation Test ◽

Radiocontrast Media

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Immediate hypersensitivity reaction followed by successful oral desensitization to ursodiol

Allergy Asthma & Clinical Immunology ◽

10.1186/s13223-021-00578-7 ◽

2021 ◽

Vol 17 (1) ◽

Author(s):

Erika Yue Lee ◽

Christine Song

Keyword(s):

Hypersensitivity Reaction ◽

Primary Biliary Cholangitis ◽

Line Treatment ◽

Second Line ◽

Immediate Hypersensitivity ◽

First Line ◽

Case Presentation ◽

Desensitization Protocol ◽

First Line Treatment ◽

Oral Desensitization

Abstract Background Immediate hypersensitivity reaction to ursodiol is rare and there is no previously published protocol on ursodiol desensitization. Case presentation A 59-year-old woman with primary biliary cholangitis (PBC) developed an immediate hypersensitivity reaction to ursodiol—the first-line treatment for PBC. When she switched to a second-line treatment, her PBC continued to progress. As such, she completed a novel 12-step desensitization protocol to oral ursodiol. She experienced recurrent pruritus after each dose following desensitization, which subsided after a month of being on daily ursodiol. Conclusion Immediate hypersensitivity reaction to ursodiol is uncommon. Our case demonstrated that this novel desensitization protocol to ursodiol could be safely implemented when alternative options are not available or have proven inferior in efficacy.

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