Immediate Hypersensitivity Reaction and Successful Rapid Desensitization to Rituximab Followed by Serum Sickness in a 4 Year Old

Abstract Background Immediate hypersensitivity reaction to ursodiol is rare and there is no previously published protocol on ursodiol desensitization. Case presentation A 59-year-old woman with primary biliary cholangitis (PBC) developed an immediate hypersensitivity reaction to ursodiol—the first-line treatment for PBC. When she switched to a second-line treatment, her PBC continued to progress. As such, she completed a novel 12-step desensitization protocol to oral ursodiol. She experienced recurrent pruritus after each dose following desensitization, which subsided after a month of being on daily ursodiol. Conclusion Immediate hypersensitivity reaction to ursodiol is uncommon. Our case demonstrated that this novel desensitization protocol to ursodiol could be safely implemented when alternative options are not available or have proven inferior in efficacy.

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Immediate‐hypersensitivity reaction to glucosamine sulfate

Allergy ◽

10.1034/j.1398-9995.1999.00139.x ◽

1999 ◽

Vol 54 (6) ◽

pp. 643-643 ◽

Cited By ~ 7

Author(s):

V Matheu ◽

Mt Gracia Bara ◽

R Pelta ◽

E Vivas ◽

M Rubio

Keyword(s):

Hypersensitivity Reaction ◽

Glucosamine Sulfate ◽

Immediate Hypersensitivity

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Human skin target cells: Nature and fate in the immediate hypersensitivity reaction

Journal of Allergy and Clinical Immunology ◽

10.1016/0091-6749(74)90003-7 ◽

1974 ◽

Vol 53 (3) ◽

pp. 150-157 ◽

Cited By ~ 2

Author(s):

T. Hubscher ◽

A. Bootello ◽

A.H. Eisen

Keyword(s):

Hypersensitivity Reaction ◽

Human Skin ◽

Target Cells ◽

Immediate Hypersensitivity

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An immediate hypersensitivity reaction induced by PEGylated recombinant factor VIII

Haemophilia ◽

10.1111/hae.14048 ◽

2020 ◽

Vol 26 (5) ◽

Author(s):

Yukiko Oh ◽

Hitomi Niijima ◽

Yuta Kawahara ◽

Tomomi Hayase ◽

Taro Shimizu ◽

...

Keyword(s):

Hypersensitivity Reaction ◽

Factor Viii ◽

Recombinant Factor Viii ◽

Immediate Hypersensitivity

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Shuang-Huang-Lian injection induces an immediate hypersensitivity reaction via C5a but not IgE

Scientific Reports ◽

10.1038/s41598-018-21843-7 ◽

2018 ◽

Vol 8 (1) ◽

Cited By ~ 10

Author(s):

Yuan Gao ◽

Rui Hou ◽

Yixin Han ◽

Qiaoling Fei ◽

Runlan Cai ◽

...

Keyword(s):

Hypersensitivity Reaction ◽

Immediate Hypersensitivity

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Recurrent immediate hypersensitivity reaction to radiocontrast media despite premedication found to be IgE-mediated

Annals of Allergy Asthma & Immunology ◽

10.1016/j.anai.2019.12.030 ◽

2020 ◽

Vol 124 (3) ◽

pp. 296-298

Author(s):

Alex Wonnaparhown ◽

Tarah Talakoub ◽

Joseph Yusin ◽

Thomas Yusin ◽

Sherwin Hariri

Keyword(s):

Hypersensitivity Reaction ◽

Immediate Hypersensitivity ◽

Radiocontrast Media ◽

Ige Mediated

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A possible case of serum sickness after ocrelizumab infusion – Commentary

Multiple Sclerosis Journal ◽

10.1177/1352458520923947 ◽

2020 ◽

Vol 27 (1) ◽

pp. 158-159

Author(s):

Sarmad Al-Araji ◽

Olga Ciccarelli

Keyword(s):

Multiple Sclerosis ◽

Case Report ◽

Hypersensitivity Reaction ◽

Current Literature ◽

Immune Complexes ◽

Serum Sickness ◽

The Third ◽

Relapsing Remitting ◽

Delayed Hypersensitivity Reaction ◽

Relapsing Remitting Multiple Sclerosis

Serum sickness is a type III delayed hypersensitivity reaction which causes deposition of immune-complexes in the tissues. It has been reported with rituximab, and in this issue of the journal, there is a case report of a patient with relapsing remitting multiple sclerosis who developed a possible serum sickness after the third infusion of ocrelizumab. In this commentary, we discuss the current literature on serum sickness, and how to diagnose and manage it. We provide our opinion on this particular case, and encourage neurologists and patients to remain vigilant of such a possibility.

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