Effects of the pine needle abortifacient, isocupressic acid, on bovine oocyte maturation and preimplantation embryo development

Maternal diabetes adversely affects preimplantation embryo development and oocyte maturation. Thus, it is important to identify ways to eliminate the effects of maternal diabetes on preimplantation embryos and oocytes. The objectives of this study were to investigate whether islet transplantation could reverse the effects of diabetes on oocytes. Our results revealed that maternal diabetes induced decreased ovulation; increased the frequency of meiotic spindle defects, chromosome misalignment, and aneuploidy; increased the relative expression levels of Mad2 and Bub1; and enhanced the sensitivity of oocytes to parthenogenetic activation. Islet transplantation prevented these detrimental effects. Therefore, we concluded that islet transplantation could reverse the effects of diabetes on oocytes, and that this technique may be useful to treat the fundamental reproductive problems of women with diabetes mellitus.

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Toxicity of beauvericin on porcine oocyte maturation and preimplantation embryo development

Reproductive Toxicology ◽

10.1016/j.reprotox.2016.07.017 ◽

2016 ◽

Vol 65 ◽

pp. 159-169 ◽

Cited By ~ 18

Author(s):

Eric J. Schoevers ◽

Regiane R. Santos ◽

Johanna Fink-Gremmels ◽

Bernard A.J. Roelen

Keyword(s):

Embryo Development ◽

Oocyte Maturation ◽

Preimplantation Embryo ◽

Preimplantation Embryo Development ◽

Porcine Oocyte

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Endoplasmic Reticulum (ER) Stress and Unfolded Protein Response (UPR) in Mammalian Oocyte Maturation and Preimplantation Embryo Development

International Journal of Molecular Sciences ◽

10.3390/ijms20020409 ◽

2019 ◽

Vol 20 (2) ◽

pp. 409 ◽

Cited By ~ 15

Author(s):

Tao Lin ◽

Jae Lee ◽

Jung Kang ◽

Hyeon Shin ◽

Ju Lee ◽

...

Keyword(s):

Endoplasmic Reticulum ◽

Er Stress ◽

Signaling Pathways ◽

Embryo Development ◽

Oocyte Maturation ◽

Preimplantation Embryo ◽

Preimplantation Embryo Development ◽

Unfolded Protein ◽

Protein Response

Mammalian oocytes and early embryos derived from in vitro production are highly susceptible to a variety of cellular stresses. During oocyte maturation and preimplantation embryo development, functional proteins must be folded properly in the endoplasmic reticulum (ER) to maintain oocyte and embryo development. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of ER stress and unfolded protein response (UPR) signaling pathways. ER stress and UPR signaling have been identified in mammalian oocytes and embryos produced in vitro, suggesting that modulation of ER stress and UPR signaling play very important roles in oocyte maturation and the development of preimplantation embryos. In this review, we briefly describe the current state of knowledge regarding ER stress, UPR signaling pathways, and their roles and mechanisms in mammalian (excluding human) oocyte maturation and preimplantation embryo development.

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