Pregnancy effects on distribution of progesterone receptors, oestrogen receptor α, glucocorticoid receptors, Ki-67 antigen and apoptosis in the bovine interplacentomal uterine wall and foetal membranes

2006 ◽  
Vol 91 (1-2) ◽  
pp. 55-76 ◽  
Author(s):  
A. Boos ◽  
J. Kohtes ◽  
V. Janssen ◽  
C. Mülling ◽  
A. Stelljes ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Glucocorticoid Receptors ◽  
Progesterone Receptors ◽  
Uterine Wall ◽  
Ki 67 ◽  
Foetal Membranes ◽  
Oestrogen Receptor Α

Expression and clinical significance of Ki-67, oestrogen and progesterone receptors in acoustic neuroma

2007 ◽  
Vol 122 (2) ◽  
pp. 125-127 ◽  
Author(s):  
S Cafer ◽  
I Bayramoglu ◽  
N Uzum ◽  
M Yilmaz ◽  
L Memis ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Acoustic Neuroma ◽  
Oestrogen Receptor ◽  
Hormone Receptors ◽  
Tumour Size ◽  
Progesterone Receptors ◽  
Inhibitory Effect ◽  
Receptor Expression ◽  
Ki 67 ◽  
Tissue Samples

AbstractObjective:The objective was to assess the presence of Ki-67, and oestrogen and progesterone hormone receptors as well as their clinical correlates in acoustic neuroma.Methods:Medical records of 59 patients who were operated on for acoustic neuroma between 1995 and 2003 were evaluated retrospectively. Formaldehyde-fixed paraffin-embedded archival acoustic neuroma specimens of the patients were used for immunohistochemical assessments of oestrogen and progesterone hormone receptors, and Ki-67 proliferative marker.Results:Tumour sizes were small (<19 mm), medium (20–39 mm) and large (>40 mm) in 21, 35 and 3 patients, respectively. On immunohistochemistry, all samples were (+) for progesterone receptor and (–) for oestrogen receptor staining. Ki-67 staining was encountered in 34 of 59 (57.6 per cent) patients, and Ki-67 values ranged from 0 per cent to 10.9 per cent (mean 1.36 per cent). There was no correlation between Ki-67, gender, tumour size and symptoms of the patients (p > 0.05).Conclusion:Oestrogen is not an important hormone in acoustic neuroma due to the absence of oestrogen receptor expression in the tissue samples. Since the progesterone receptor is expressed in all acoustic neuroma samples, further studies are necessary to find out about the inhibitory effect of antiprogesterone treatment on acoustic neuroma growth, which may be important particularly in elderly people or high-risk patients. Although Ki-67 is expressed in the majority of acoustic neuromas, it is not an important marker in clinical practice due to a lack of any correlation with the clinical parameters.

Oestrogen receptor α promotes prostate cancer progression through dual actions in both epithelia and stroma

2015 ◽  
Author(s):  
Mitchell Lawrence ◽  
Ruth Pidsley ◽  
Stuart Ellem ◽  
Luc Furic ◽  
Shalima Nair ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Oestrogen Receptor ◽  
Prostate Cancer Progression ◽  
Oestrogen Receptor Α

Oestrogen Receptor α in the Heart is Critical for Protection Against Systemic Obesity in Female Mice

2021 ◽  
Vol 30 ◽  
pp. S123
Author(s):  
Y. Tham ◽  
B. Bernardo ◽  
L. Woon ◽  
S. Yildiz ◽  
C. Tai ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Female Mice ◽  
Oestrogen Receptor Α

Progestin receptors in prolactin and growth hormone producing tumours in rats

1982 ◽  
Vol 100 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Oddvar Naess ◽  
Egil Haug ◽  
Arne Attramadal ◽  
Kaare M. Gautvik
Keyword(s):  
Growth Hormone ◽  
Glucocorticoid Receptors ◽  
Progesterone Receptors ◽  
Pituitary Tumour ◽  
Tumour Cells ◽  
Female Rats ◽  
Progestin Receptors ◽  
High Affinity ◽  
Protein Nature ◽  
Specific Receptors

Abstract. Progesterone and corticosterone have a similar effect on the production of growth hormone (GH) and prolactin (Prl) by pituitary tumour cells (GH3 cells) in culture. Previously we have shown that progesterone has a high affinity for the glucocorticoid receptors in these cells. Progesterone may therefore exert its effects through binding to the glucocorticoid receptor. The aim of the present study was to investigate if the GH3 tumour cells and an oestrogen induced pituitary tumour, which also produce GH and Prl, possess specific receptors for progesterone. Both the GH3 tumours and the oestrogen induced pituitary tumour were in fact found to possess cytoplasmatic receptor molecules for progesterone by using the potent progestin R5020 as a marker. Isoelectric focusing revealed one binding component (pH 5.9), which was of protein nature. The binding was of high affinity (Kd 2 × 10−9 mol/l). In the oestrogen induced tumour, the maximal binding was 70 fmol/mg cytosol protein. In female rats with GH3 tumours the binding was 55 fmol/mg cytosol protein. Priming of the animals with 1 mg oestradiol-valerate increased the binding to 116 fmol/mg cytosol protein, whereas very little binding was found in GH3 tumours from rats castrated 7 days before sacrifice. The receptors in the oestrogen induced pituitary tumour and the GH3 tumours exhibited high affinity for R5020 and progesterone, whereas corticosterone had no significant affinity for the receptors. Using exchange assay, it was demonstrated that the cytoplasmic progestin receptors could be translocated to the nucleus after administration of progesterone to the animals. Thus, the presence of specific progesterone receptors, different from the glucocorticoid receptors, strongly indicates that the effects of progesterone on GH and Prl production are mediated through the progesterone receptors.

scholarly journals Sex Differences in Expression of Oestrogen Receptor α but not Androgen Receptor mRNAs in the Foetal Lamb Brain

2014 ◽  
Vol 26 (5) ◽  
pp. 321-328 ◽  
Author(s):  
R. C. Reddy ◽  
C. T. Estill ◽  
M. Meaker ◽  
F. Stormshak ◽  
C. E. Roselli
Keyword(s):  
Sex Differences ◽  
Androgen Receptor ◽  
Oestrogen Receptor ◽  
Oestrogen Receptor Α ◽  
Receptor Mrnas ◽  
Foetal Lamb

scholarly journals Oestrogen receptor α AF-1 and AF-2 domains have cell population-specific functions in the mammary epithelium

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Stéphanie Cagnet ◽  
Dalya Ataca ◽  
George Sflomos ◽  
Patrick Aouad ◽  
Sonia Schuepbach-Mallepell ◽  
...  
Keyword(s):  
Cell Population ◽  
Oestrogen Receptor ◽  
Mammary Epithelium ◽  
Oestrogen Receptor Α
Sign in / Sign up

Export Citation Format

Share Document