Risk of ischemic heart disease death from impaired fasting glucose and impaired renal function attenuated by their interaction among male hypertensive subjects

Nonenzymatic reactions between glucose and proteins yield advanced glycation end products (AGE) such as pentosidine. AGE accumulate in diabetic patients, alter the structure and function of tissue proteins, stimulate cellular response, and have thus been implicated in diabetic tissue damage. The present study was undertaken to assess the factors determining plasma total pentosidine level in diabetic patients and the possible relation between plasma pentosidine level and diabetic complications. In diabetic patients, including patients with renal failure, plasma pentosidine levels, assessed by HPLC assay, were correlated with serum creatinine (P < 0.0001). In patients with normal renal function, pentosidine levels were correlated with blood glucose control (hemoglobin Alc: P = 0.0028; fructoselysine: P = 0.0133), serum creatinine (P = 0.029), patient age (P = 0.0416), duration of diabetes (P = 0.0431), and total cholesterol (P = 0.0056) and LDL-cholesterol (P = 0.0208). Multiple regression analysis revealed an independent influence of hemoglobin Alc and serum creatinine on pentosidine levels (r2 = 0.216, P = 0.0026). Pentosidine levels were higher in patients with than in those without hypertension (P = 0.043) or ischemic heart diseases (P = 0.0061). No such differences were observed between patients with and without albuminuria or retinopathy. Multiple regression analysis revealed an independent influence of plasma pentosidine on the presence of hypertension (r2 = 0.129, P = 0.0382) and of plasma pentosidine and HDL-cholesterol on the presence of ischemic heart disease (r2 = 0.326, P = 0.0012). The present study demonstrated that plasma pentosidine level was significantly influenced by the quality of glycemic control and renal function. Pentosidine level was also correlated with hypertension and ischemic heart disease, and might be taken as a biomarker of diabetic cardiovascular risk.

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Community Noise Exposure and its Effect on Blood Pressure and Renal Function in Patients with Hypertension and Cardiovascular Disease

Folia Medica ◽

10.1515/folmed-2017-0045 ◽

2017 ◽

Vol 59 (3) ◽

pp. 344-356 ◽

Cited By ~ 1

Author(s):

Angel M. Dzhambov ◽

Mariya P. Tokmakova ◽

Penka D. Gatseva ◽

Nikolai G. Zdravkov ◽

Dolina G. Gencheva ◽

...

Keyword(s):

Blood Pressure ◽

Renal Function ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Filtration Rate ◽

Noise Exposure ◽

Traffic Noise ◽

Ischemic Heart ◽

The City ◽

At Home

AbstractBackground:Road traffic noise (RTN) is a risk factor for cardiovascular disease (CVD) and hypertension; however, few studies have looked into its association with blood pressure (BP) and renal function in patients with prior CVD.Aim:This study aimed to explore the effect of residential RTN exposure on BP and renal function in patients with CVD from Plovdiv Province.Materials and methods:We included 217 patients with ischemic heart disease and/or hypertension from three tertiary hospitals in the city of Plovdiv (March – May 2016). Patients’ medical history, medical documentation, and medication regimen were reviewed, and blood pressure and anthropometric measurements were taken. Blood samples were analyzed for creatinine, total cholesterol, and blood glucose. Participants also filled a questionnaire. Glomerular filtration rate was estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. All participants were asked about their annoyance by different noise sources at home, and those living in the city of Plovdiv (n = 132) were assigned noise map Ldenand Lnightexposure. The effects of noise exposure on systolic blood pressure (SBP), diastolic blood pressure (DBP), and estimated glomerular filtration rate (eGFR) were explored using mixed linear models.Results:Traffic noise annoyance was associated with higher SBP in the total sample. The other noise indicators were associated with non-significant elevation in SBP and reduction in eGFR. The effect of Ldenwas more pronounced in patients with prior ischemic heart disease/stroke, diabetes, obesity, not taking Ca-channel blockers, and using solid fuel/gas at home. Lnighthad stronger effect among those not taking statins, sleeping in a bedroom with noisy façade, having a living room with quiet façade, and spending more time at home. The increase in Ldenwas associated with a significant decrease in eGFR among men, patients with ischemic heart disease/stroke, and those exposed to lower air pollution. Regarding Lnight, there was significant effect modification by gender, diabetes, obesity, and time spent at home. In some subgroups, the effect of RTN was statistically significant.Conclusions:Given that generic risk factors for poor progression of cardiovascular diseases cannot be controlled sufficiently at individual level, environmental interventions to reduce residential noise exposure might result in some improvement in the management of blood pressure and kidney function in patients with CVD.

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363 RELATIONSHIP BETWEEN THE NUMBER OF STENOSED CORONARY ARTERIES AND RENAL FUNCTION IN PATIENTS WITH ISCHEMIC HEART DISEASE

Atherosclerosis Supplements ◽

10.1016/s1567-5688(11)70364-6 ◽

2011 ◽

Vol 12 (1) ◽

pp. 78

Author(s):

N. Bardachenko ◽

O. Kuryata ◽

L. Bardachenko

Keyword(s):

Renal Function ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Coronary Arteries ◽

Ischemic Heart

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METABOLIC SYNDROME IN PATIENTS WITH ISCHEMIC HEART DISEASE

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2014.3.4 ◽

2014 ◽

pp. 29-38

Author(s):

Trong Nghia Nguyen ◽

Thi Bich Thuan Le

Keyword(s):

Metabolic Syndrome ◽

Risk Factor ◽

Heart Disease ◽

Coronary Artery ◽

Waist Circumference ◽

Ischemic Heart Disease ◽

Fasting Glucose ◽

Ischemic Heart ◽

Common Pattern ◽

Low Hdl

Objectives: To study on characteristíc of the metabolic syndrome (MS) in patients with ischemic heart disease (IHD) using consensus criteria of IDF, AHA/NHLBI, WHF and IASO (2009); to the relationship and correlation between the stenosis level of coronary artery disease and components of the MS in patients with IHD. Subjects and methods: A cross-sectional study was done in 123 patients with IHD at Cardiovascular Center, Hue Central Hospital. Coronary artery disease’s lesions were determined through coronary angiography. The stenosis degree of coronary artery was evaluated according to Pujadas G, the lesions of coronary artery were categorized according to AHA/ACC and were classified by using Gensini index. MS was diagnosed by the consensus criteria of IDF, AHA/NHLBI, WHF and IASO (published in 2009). Results: The MS prevalence was 56.9%, the age ≥ 60 years accounted for 84.29%, of which the group of 60 – 69 undertook the highest prevalence of this syndrome, with 73.33%. (i) The MS prevalence elevated in proportion to BMI, of which the group with BMI ≥ 25 expressed the highest prevalence (85.29%), (ii) Hypertriglyceridemia (accounted for 84.29%) and elevated fasting glucose (Go) (81.83%) were two most popular components, (iii) The most common pattern of MS consisted of 3 components (21.95%): Hypertension (HT) – hypertriglyceridemia- low HDL–c (23.08%), hypertriglyceridemia - low HDL-c- elevated Go (19.23%), (iv) The most common pattern which consists of 4 component was: HT-hypertriglyceridemia-low HDL-c- elevated Go (accounted for 30.44%), then increased waist circumference- HT- hypertriglyceridemia- elevated Go (21.74%), (v) Patients with MS had more frequent number of injured branches of coronary artery and higher degree of stenosis than those without MS (p<0.01), (vi) There was a moderately positive correlation between Gensini index and waist circumference (r=0.423; p<0.01), systolic blood pressure (r=0,448, p <0.05), serum triglycerid (r=0.383; p<0.05) and fasting glucose (r=0.531; p<0.01). There was an inverse correlation between Gensini index and serum HDL-c level (r=-0.301; p<0,01). Conclusion: The MS was a risk factor of cardiovascular disease and associated with the risk of coronary morbidity, the likelihood of more severe, more frequent number of coronary artery’s injured branches. Keyword: Metabolic syndrome, ischemic heart disease, risk factor

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Mild renal dysfunction is associated with increased risk of ischemic heart disease disease among healthy adults

European Heart Journal ◽

10.1093/eurheartj/ehab724.2472 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

Author(s):

S Tiosano ◽

A Fardman ◽

A Kaplan ◽

M Kalstein ◽

Y Moshkovits ◽

...

Keyword(s):

Renal Function ◽

Heart Disease ◽

Ischemic Heart Disease ◽

Renal Dysfunction ◽

Cox Regression ◽

Healthy Adults ◽

Ischemic Heart ◽

Study Endpoint ◽

Mortality Data ◽

Increased Risk

Abstract Introduction The relationship between ischemic heart disease (IHD) and advanced chronic kidney disease is well established. However, there is a paucity of data regarding the long-term association in between renal function and incidence of IHD. Purpose To study the remote association between point renal function and future incidence of ischemic heart disease among healthy adults. Methods We evaluated asymptomatic self-referred adults who participated in a medical screening program. All subjects were free of IHD at baseline. Glomerular Filtration Rate (GFR) was calculated by CKD-EPI and divided into quartiles (Q1 represents the lowest quartile). Study endpoint was the development of IHD which was externally adjudicated by a physician. Mortality data were available for all subjects from national registry. Cox regression models were applied while adjusting for confounders. Results The final study population included 27,647 subjects (68% men) with a mean age of 47 years. At baseline (first screening visit), median GFR by CKD-EPI was 84 [IQR 74; 95] and 86 [IQR 74.; 101] mL/min per 1.73m2 for men women, respectively. During median follow up of 6 years [IQR 2; 12], 2,286 (8%) of subjects developed IHD, of whom 1,912 (10%) were men and 374 (4%) were women. Incident IHD was in 964 (13.98%), 705 (10.22%), 437 (6.34%) and 171 (2.48%) subjects from GFR Q1-Q4, respectively. Kaplan Meier survival analysis demonstrated a graded increased risk of IHD with decreasing eGFR quartiles (p Log rank <.001; Figure 1). Multivariate cox regression analysis revealed hazard ratio of 1.26 (95% CI 1.06, 1.51), 1.43 (95% CI 1.20, 1.70), and 1.25 (1.05, 1.50) for IHD incidence for Q1-Q3, respectively (using Q4 as reference). While considering GFR as a continuous variable, each 10 units increase in GFR was significantly associated with 4% less risk for developing IHD - HR 0.96 (95% CI 0.93–1.00, p=0.04). Conclusion Mild renal dysfunction even within the normal range is independently associated with remote risk of IHD among young apparently healthy adults. Cardiovascular screening should be considered among young patients with reduced renal function, even within normal reference range. FUNDunding Acknowledgement Type of funding sources: None. Figure 1

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