scholarly journals 82O Genomic evolution of metastatic tumours under therapeutic pressure

2020 ◽  
Vol 31 ◽  
pp. S274
Author(s):  
J. Van De Haar ◽  
L.R. Hoes ◽  
P. Roepman ◽  
E. Cuppen ◽  
L.F. Wessels ◽  
...  
2021 ◽  
Vol 41 (2) ◽  
pp. 228-235
Author(s):  
Bai-sheng Li ◽  
Zhen-cui Li ◽  
Yao Hu ◽  
Li-jun Liang ◽  
Li-rong Zou ◽  
...  

2021 ◽  
Vol 22 (3) ◽  
pp. 1298
Author(s):  
Fabio Arena ◽  
Simona Pollini ◽  
Gian Maria Rossolini ◽  
Maurizio Margaglione

Since early 2020, the COVID-19 pandemic has caused an excess in morbidity and mortality rates worldwide. Containment strategies rely firstly on rapid and sensitive laboratory diagnosis, with molecular detection of the viral genome in respiratory samples being the gold standard. The reliability of diagnostic protocols could be affected by SARS-CoV-2 genetic variability. In fact, mutations occurring during SARS-CoV-2 genomic evolution can involve the regions targeted by the diagnostic probes. Following a review of the literature and an in silico analysis of the most recently described virus variants (including the UK B 1.1.7 and the South Africa 501Y.V2 variants), we conclude that the described genetic variability should have minimal or no effect on the sensitivity of existing diagnostic protocols for SARS-CoV-2 genome detection. However, given the continuous emergence of new variants, the situation should be monitored in the future, and protocols including multiple targets should be preferred.


2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Alberto J. Valencia-Botín ◽  
María E. Cisneros-López

Wheat is affected by some pathovars ofPseudomonas syringaeand by otherPseudomonasspecies. Of these,P. syringaepv.syringaeis the major one responsible for reduction. Recent studies have been made to characterize and identify the pathogen and to determine its aggressiveness and the pattern of colonization in seed and its effects on seed yield, yield components, and source-sink relationships during postanthesis. It was found that the reduction in the aerial biomass production is the best way to evaluate the aggressiveness of this bacterium, and the spray inoculation is good tool to make evaluations at seedling stage. The characterization of bacteria fingerprintings with molecular markers such as RAPD-PCR, ERIC, and REP-PCR is available. Genomic evolution has been elucidated with next-generation genome sequencing. Also, the colonization pattern shows that, early on, microcolonies are frequently detected in the aleurone layer, later in the endosperm and finally close to the crease and even in some cells of the embryo itself. In the wheat cultivars Seri M82 and Rebeca F2000 seed yield and its components are negatively affected. In general,P. syringaepv.syringaereduces the plant height, seed yield, and yield components, as well as the growth of most organs. When this bacterium attacks, the stems are the predominant sink organs and the leaf laminae and panicles are the predominant source organs.


2002 ◽  
Vol 19 (3) ◽  
pp. 230-238 ◽  
Author(s):  
D. Rokyta ◽  
M. R. Badgett ◽  
I. J. Molineux ◽  
J. J. Bull
Keyword(s):  

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