scholarly journals 1549P Pazopanib exposure in advanced soft tissue and bone sarcoma: A pharmacokinetic/pharmacodynamic analysis

2021 ◽  
Vol 32 ◽  
pp. S1125
Author(s):  
M-S. Minot ◽  
P. Boudou Rouquette ◽  
A. Jouinot ◽  
D. Balakirouchenane ◽  
C. Tlemsani ◽  
...  
Author(s):  
Jasminka Igrec ◽  
Michael H. Fuchsjäger

Background In the diagnosis of bone and soft-tissue sarcomas, the continuous advancement of various imaging modalities has improved the detection of small lesions, surgical planning, assessment of chemotherapeutic effects, and, importantly, guidance for surgery or biopsy. Method This review was composed based on a PubMed literature search for the terms “bone sarcoma,” “bone cancer” and “soft tissue sarcoma,” “imaging,” “magnetic resonance imaging”, “computed tomography”, “ultrasound”, “radiography”, and “radiomics” covering the publication period 2005–2020. Results and Conclusion As discussed in this review, radiography, ultrasound, CT, and MRI all play key roles in the imaging evaluation of bone and soft-tissue sarcomas. In daily practice, advanced MRI techniques complement standard MRI but remain underused, as they are considered time-consuming, technically challenging, and not reliable enough to replace biopsy and histology. PET/MRI and radiomics have shown promise regarding the imaging of sarcomas in the future. Key Points:  Citation Format


1988 ◽  
Vol 4 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Vivien H. C. Bramwell ◽  
A. Santoro ◽  
J. Rouesse ◽  
H. Mouridsen ◽  
W. Steward ◽  
...  

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