Lumpy skin disease: Preliminary vaccine efficacy assessment and overview on outbreak impact in dairy cattle at Debre Zeit, central Ethiopia

2013 ◽  
Vol 98 (2) ◽  
pp. 261-265 ◽  
Author(s):  
Gelagay Ayelet ◽  
Yebeyen Abate ◽  
Tesfaye Sisay ◽  
Haileleul Nigussie ◽  
Esayas Gelaye ◽  
...  
2020 ◽  
Vol 60 (15) ◽  
pp. 1838
Author(s):  
Belay Duguma

Context Smallholder dairy farming is becoming an important source of food, income and employment for many urban dwellers in Ethiopia. However, suboptimal productivity is a major constraint due to diseases and poor management practices. Aims The present work aimed at assessing management practices, dairy cattle diseases, and methods used by farmers to identify diseases on smallholdings in selected towns of Jimma zone, south-western Ethiopia. Methods Data for the study were obtained by surveying 52 dairy-keeping farmers by using a semi-structured questionnaire and personal observations. Key results The mean herd size of indigenous and crossbred cattle was 5 ± 0.04 and 2 ± 0.4 respectively. Natural pasture was the main source of feed with supplementation, mainly with agro-industrial by-products, concentrate mixes, non-conventional feeds and crop residues. In total, 75% of the respondents practiced a free-grazing system. Most (64%) of the respondents used natural service for breeding. In all, 64% and 35% of the respondents washed their hands and the teats respectively, before milking. In the order of decreasing percentage of respondents, the most frequently reported dairy cattle health problems were tick infestation, mastitis, lumpy skin disease, blackleg, heart water, facioliasis, trypanosomiasis, foot-and-mouth disease, pasteurellosis, brucellosis and anthrax. Repeated breeding, retained fetal membranes, abortion, stillbirths and dystocia were the common reproductive health problems, in a decreasing order of the reported percentage. Lumpy skin disease was reported as a major cause of calf and lactating-cow deaths. A total of 89% of the respondents used veterinary medicines to treat their sick animals. About 24% of the respondents stated culling of their animals due to old age, lack of space, infertility, feed shortage, need for cash and low production, in a decreasing order of importance. Conclusions The results showed farmers are well knowledgeable in cattle production practices and are actually mitigating effects of most disease challenges in their farms, which may have resulted in low milk productivity. Implications The farmers in the current study had some knowledge of milk production activities that may be recommended for similar settings, especially on how to manage dairy cattle production under smallholder farms, obviously including the occurrence of diseases, which they are managing appropriately with available technologies including vaccines and treatment. These could be used as baseline data by dairy stakeholders and policy makers during the formulation and implementation of policies for sustainable growth and development of smallholder dairy for similar settings.


Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 473
Author(s):  
Andy Haegeman ◽  
Ilse De Leeuw ◽  
Laurent Mostin ◽  
Willem Van Campe ◽  
Laetitia Aerts ◽  
...  

Vaccines form the cornerstone of any control, eradication and preventative strategy and this is no different for lumpy skin disease. However, the usefulness of a vaccine is determined by a multiplicity of factors which include stability, efficiency, safety and ease of use, to name a few. Although the vaccination campaign in the Balkans against lumpy skin disease virus (LSDV) was successful and has been implemented with success in the past in other countries, data of vaccine failure have also been reported. It was therefore the purpose of this study to compare five homologous live attenuated LSDV vaccines (LSDV LAV) in a standardized setting. All five LSDV LAVs studied were able to protect against a challenge with virulent LSDV. Aside from small differences in serological responses, important differences were seen in side effects such as a local reaction and a Neethling response upon vaccination between the analyzed vaccines. These observations can have important implications in the applicability in the field for some of these LSDV LAVs.


Vaccines ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 4
Author(s):  
Janika Wolff ◽  
Tom Moritz ◽  
Kore Schlottau ◽  
Donata Hoffmann ◽  
Martin Beer ◽  
...  

Capripox virus (CaPV)-induced diseases (lumpy skin disease, sheeppox, goatpox) are described as the most serious pox diseases of livestock animals, and therefore are listed as notifiable diseases under guidelines of the World Organisation for Animal Health (OIE). Until now, only live-attenuated vaccines are commercially available for the control of CaPV. Due to numerous potential problems after vaccination (e.g., loss of the disease-free status of the respective country, the possibility of vaccine virus shedding and transmission as well as the risk of recombination with field strains during natural outbreaks), the use of these vaccines must be considered carefully and is not recommended in CaPV-free countries. Therefore, innocuous and efficacious inactivated vaccines against CaPV would provide a great tool for control of these diseases. Unfortunately, most inactivated Capripox vaccines were reported as insufficient and protection seemed to be only short-lived. Nevertheless, a few studies dealing with inactivated vaccines against CaPV are published, giving evidence for good clinical protection against CaPV-infections. In our studies, a low molecular weight copolymer-adjuvanted vaccine formulation was able to induce sterile immunity in the respective animals after severe challenge infection. Our findings strongly support the possibility of useful inactivated vaccines against CaPV-infections, and indicate a marked impact of the chosen adjuvant for the level of protection.


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