scholarly journals Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit

2022 ◽  
pp. 100669
Author(s):  
Zhangbin Chen ◽  
Yifei Ma ◽  
Zhitang Guo ◽  
Dingyuan Song ◽  
Zili Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

scholarly journals Reduced ubiquitin-specific protease 9X expression induced by RNA interference inhibits the bioactivity of hepatocellular carcinoma cells

2015 ◽  
Vol 10 (1) ◽  
pp. 268-272 ◽  
Author(s):  
HUIWEN HU ◽  
CHENGYONG TANG ◽  
QINGHU JIANG ◽  
WEI LUO ◽  
JIMING LIU ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Rna Interference ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

scholarly journals Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wei Zhang ◽  
Jingxin Zhang ◽  
Chenzhou Xu ◽  
Shiqing Zhang ◽  
Saiyan Bian ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

scholarly journals High Expression of Ubiquitin-Specific Protease 39 and Its Roles in Prognosis in Patients with Hepatocellular Carcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Yu Liao ◽  
Lin Li ◽  
Huabao Liu ◽  
Yi Song
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Features ◽  
Mrna Level ◽  
Diagnostic Value ◽  
Histologic Grade ◽  
High Expression ◽  
Pathologic Stage ◽  
T Stage ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

Background. Ubiquitin-specific protease 39 is mainly involved in mRNA splicing and multiple kinds of tumors. Accumulating evidence has shown that USP39 participated in the proliferation and metastasis of hepatocellular carcinoma (HCC). The present study aimed to demonstrate the association between USP39 expression and clinical features and the diagnostic value in HCC based on the Cancer Genome Atlas (TCGA). Methods. A comprehensive analysis for expression of USP39 in HCC was conducted by using multiple databases. The mRNA level of USP39, clinical features, survival rate, and diagnostic value in HCC were analyzed using data from TCGA. The Gene Set Enrichment Analysis (GSEA) was conducted to analyze signaling pathways correlated with USP39 expression in HCC. Results. The mRNA level of USP39 was significantly elevated in HCC. The expression of USP39 showed significant correlation with T stage, pathologic stage, tumor status, age, and histologic grade. Logistic analysis demonstrated that high expression of USP39 was significantly associated with older age, tumor status, advanced pathologic stage, T stage, and higher histologic grade. Univariate Cox regression analysis showed that high expression of USP39 was significantly associated with advanced T stage, pathological stage, and tumor status. Multivariate Cox analysis confirmed the result that USP39 expression was an independent prognostic factor for overall survival (OS) in HCC. Results of Kaplan–Meier curves showed that high expression of USP39 had a significant association with poor OS, disease-free survival (DSS), and progress-free interval (PFI) in HCC. ROC analysis indicated that USP39 could be regarded as a promising marker for distinguishing HCC from nontumor. Conclusion. The increased USP39 might play roles in the progression, diagnosis, and prognosis of HCC.

scholarly journals Ubiquitin-specific protease 11 serves as a marker of poor prognosis and promotes metastasis in hepatocellular carcinoma

2018 ◽  
Vol 98 (7) ◽  
pp. 883-894 ◽  
Author(s):  
Sheng Zhang ◽  
Chengrong Xie ◽  
Honghe Li ◽  
Kang Zhang ◽  
Jie Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Poor Prognosis ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

scholarly journals Comprehensive analysis of ubiquitin‐specific protease 1 reveals its importance in hepatocellular carcinoma

2020 ◽  
Vol 53 (10) ◽  
Author(s):  
Yalei Zhao ◽  
Chen Xue ◽  
Zhongyang Xie ◽  
Xiaoxi Ouyang ◽  
Lanjuan Li
Keyword(s):  
Hepatocellular Carcinoma ◽  
Comprehensive Analysis ◽  
Specific Protease ◽  
Ubiquitin Specific Protease
Sign in / Sign up

Export Citation Format

Share Document