Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A

2020 ◽  
Author(s):  
Bin Xiong ◽  
Junwei Huang ◽  
Yan Liu ◽  
Min Zou ◽  
Zhibo Zhao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Specific Protease ◽  
Ubiquitin Specific Protease ◽  
Protease 2A

scholarly journals Reduced ubiquitin-specific protease 9X expression induced by RNA interference inhibits the bioactivity of hepatocellular carcinoma cells

2015 ◽  
Vol 10 (1) ◽  
pp. 268-272 ◽  
Author(s):  
HUIWEN HU ◽  
CHENGYONG TANG ◽  
QINGHU JIANG ◽  
WEI LUO ◽  
JIMING LIU ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Rna Interference ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

scholarly journals Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma

2014 ◽  
Vol 35 (7) ◽  
pp. 1500-1509 ◽  
Author(s):  
Chun-Lin Wang ◽  
Jun-Yu Wang ◽  
Zhen-Yang Liu ◽  
Xiao-Mei Ma ◽  
Xiao-Wen Wang ◽  
...  
Keyword(s):  
Intrinsic Apoptotic Pathway ◽  
Apoptotic Pathway ◽  
Specific Protease ◽  
Ubiquitin Specific Protease ◽  
Protease 2A

Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas

2016 ◽  
Vol 363 ◽  
pp. 249-252 ◽  
Author(s):  
Mohammad Reza Boustani ◽  
Reza Jalili Khoshnood ◽  
Fermoozan Nikpasand ◽  
Zabihollah Taleshi ◽  
Koorosh Ahmadi ◽  
...  
Keyword(s):  
Related Factor ◽  
Nuclear Factor ◽  
Human Gliomas ◽  
Specific Protease ◽  
Ubiquitin Specific Protease ◽  
Protease 2A

scholarly journals Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit

2022 ◽  
pp. 100669
Author(s):  
Zhangbin Chen ◽  
Yifei Ma ◽  
Zhitang Guo ◽  
Dingyuan Song ◽  
Zili Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

scholarly journals Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wei Zhang ◽  
Jingxin Zhang ◽  
Chenzhou Xu ◽  
Shiqing Zhang ◽  
Saiyan Bian ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

scholarly journals High Expression of Ubiquitin-Specific Protease 39 and Its Roles in Prognosis in Patients with Hepatocellular Carcinoma

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Yu Liao ◽  
Lin Li ◽  
Huabao Liu ◽  
Yi Song
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Features ◽  
Mrna Level ◽  
Diagnostic Value ◽  
Histologic Grade ◽  
High Expression ◽  
Pathologic Stage ◽  
T Stage ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

Background. Ubiquitin-specific protease 39 is mainly involved in mRNA splicing and multiple kinds of tumors. Accumulating evidence has shown that USP39 participated in the proliferation and metastasis of hepatocellular carcinoma (HCC). The present study aimed to demonstrate the association between USP39 expression and clinical features and the diagnostic value in HCC based on the Cancer Genome Atlas (TCGA). Methods. A comprehensive analysis for expression of USP39 in HCC was conducted by using multiple databases. The mRNA level of USP39, clinical features, survival rate, and diagnostic value in HCC were analyzed using data from TCGA. The Gene Set Enrichment Analysis (GSEA) was conducted to analyze signaling pathways correlated with USP39 expression in HCC. Results. The mRNA level of USP39 was significantly elevated in HCC. The expression of USP39 showed significant correlation with T stage, pathologic stage, tumor status, age, and histologic grade. Logistic analysis demonstrated that high expression of USP39 was significantly associated with older age, tumor status, advanced pathologic stage, T stage, and higher histologic grade. Univariate Cox regression analysis showed that high expression of USP39 was significantly associated with advanced T stage, pathological stage, and tumor status. Multivariate Cox analysis confirmed the result that USP39 expression was an independent prognostic factor for overall survival (OS) in HCC. Results of Kaplan–Meier curves showed that high expression of USP39 had a significant association with poor OS, disease-free survival (DSS), and progress-free interval (PFI) in HCC. ROC analysis indicated that USP39 could be regarded as a promising marker for distinguishing HCC from nontumor. Conclusion. The increased USP39 might play roles in the progression, diagnosis, and prognosis of HCC.

scholarly journals Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas

Oral Oncology ◽  
2009 ◽  
Vol 45 (10) ◽  
pp. e134-e139 ◽  
Author(s):  
Sabrina Daniela da Silva ◽  
Isabela Werneck Cunha ◽  
Inês Nobuko Nishimoto ◽  
Fernando Augusto Soares ◽  
Dirce Maria Carraro ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Squamous Cell ◽  
Fatty Acid Synthase ◽  
Squamous Cell Carcinomas ◽  
Oral Squamous Cell Carcinomas ◽  
Erbb2 Expression ◽  
Specific Protease ◽  
Clinicopathological Significance ◽  
Ubiquitin Specific Protease ◽  
Protease 2A
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