Mediation Model for the Relationship between Facial Expression and Quality of Life in Parkinson’s Disease

Background: Hypokinetic dysarthria and dysphagia are known features of Parkinson’s disease; however, self-perception of their handicapping effects on emotional, physical, and functional aspects of quality of life over disease duration is less understood. Objective: 1) Based upon patient self-perception, to determine the relationship of the handicapping effects of dysphagia and dysphonia with time since diagnosis in individuals with Parkinson’s disease; 2)To determine if there is a relationship between voice and swallowing handicap throughout the course of Parkinson’s disease. Method: 277 subjects completed the Dysphagia Handicap Index and the Voice Handicap Index. Subjects were divided into three groups based on disease duration: 0–4 years, 5–9 years, and 10 + years. Results: Subjects in the longer duration group identified significantly greater perceptions of voice and swallowing handicap compared to the shorter duration groups. There was a significant positive correlation between the DHI and VHI. Conclusion: Self-perception of swallowing and voice handicap in Parkinson’s disease are associated with later stages of disease and progress in a linear fashion. Self-perception of voice and swallowing handicap parallel each other throughout disease progression in Parkinson’s disease. Individuals may be able to compensate for changes in voice and swallowing early while sensory perceptual feedback is intact. Results support early targeted questioning of patient self-perception of voice and swallowing handicap as identification of one problem indicates awareness of the other, thus creating an opportunity for early treatment and maintenance of swallowing and communication quality of life for as long as possible.

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The relationship of pain and health-related quality of life in Korean patients with Parkinson’s disease

Acta Neurologica Scandinavica ◽

10.1111/j.1600-0404.2008.01114.x ◽

2009 ◽

Vol 119 (6) ◽

pp. 397-403 ◽

Cited By ~ 25

Author(s):

J. H. Roh ◽

B.-J. Kim ◽

J.-H. Jang ◽

W.-K. Seo ◽

S.-H. Lee ◽

...

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Health Related Quality ◽

Korean Patients ◽

Related Quality ◽

Health Related ◽

Relationship Of ◽

The Relationship

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Depressive symptoms and perception of quality of life in Parkinson's disease

Arquivos de Neuro-Psiquiatria ◽

10.1590/s0004-282x2009000200006 ◽

2009 ◽

Vol 67 (2a) ◽

pp. 203-208 ◽

Cited By ~ 24

Author(s):

Paula Scalzo ◽

Arthur Kummer ◽

Francisco Cardoso ◽

Antonio Lucio Teixeira

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Depressive Symptoms ◽

Well Being ◽

Poor Quality ◽

Life Questionnaire ◽

Perception Of Quality ◽

The Relationship

BACKGROUND: Depression has been proposed as a major contributor to poor quality of life (QoL) in Parkinson's disease (PD). OBJECTIVE: To evaluate the relationship between depressive symptoms and QoL in subjects with PD. METHOD: Beck Depression Inventary (BDI) was used to evaluate depressive symptoms and Parkinson's Disease Quality of Life Questionnaire (PDQ-39) to assess the perception of the QoL. RESULTS: Thirty seven patients (19 male/ 18 female) with a typical onset PD and mean disease duration of 7.7 years were studied. Higher scores on BDI correlated with poorer perception of the QoL. This association occurred at the expense of the following PDQ39 domains: mobility, activities of daily living, social support, cognition and emotional well-being dimensions. PD severity also correlated with QoL. CONCLUSION: Our study corroborates the assumption that depressive symptoms contributed significantly to QoL in PD.

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The impact of poor medication knowledge on health-related quality of life in people with Parkinson’s disease: a mediation analysis

Quality of Life Research ◽

10.1007/s11136-021-03024-8 ◽

2021 ◽

Author(s):

Hannah M. Zipprich ◽

Sarah Mendorf ◽

Aline Schönenberg ◽

Tino Prell

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Cognitive Assessment ◽

Medication Knowledge ◽

Sf 36 ◽

Related Quality ◽

Health Related ◽

The Relationship

Abstract Purpose This study aimed to determine how limited medication knowledge as one aspect of health literacy contributes to poorer health-related quality of life (HRQoL) in people with Parkinson’s disease (PD). Methods Demographical data, PD-specific data (MDS-Unified Parkinson’s Disease-Rating Scale, Nonmotor symptom scale), and data about depressive symptoms (Beck’s depression inventory), cognition (Montreal cognitive assessment), HRQoL (Short-Form Health Questionnaire-36, SF-36), and medication knowledge (names, time of taking, indication, dosage) were assessed in 193 patients with PD. Multivariate analysis of variance (MANOVA), multivariate analysis of covariance, and mediation analyses were used to study the relationship between medication knowledge and HRQoL in combination with different mediators and covariates. Results Overall, 43.5% patients showed deficits in at least one of the 4 knowledge items, which was associated with higher age, number of medications per day and depression level, and poorer cognitive function, motor function, and lower education level. Using one-way MANOVA, we identified that medication knowledge significantly impacts physical functioning, social functioning, role limitations due to physical problems, and role limitations due to emotional problems. Mediation models using age, education level, and gender as covariates showed that the relationship between knowledge and SF-36 domains was fully mediated by Beck’s Depression Inventory but not by Montreal Cognitive Assessment. Conclusions Patients who expressed unawareness of their medication did not necessarily have cognitive deficits; however, depressive symptoms may instead be present. This concomitant depressive symptomatology is crucial in explaining the contribution of nonadherence and decreased medication knowledge to poor quality of life.

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Assessment of the quality of life and the relationship between its level and sociodemographic factors and physical activity in the group of patients with Parkinson’s disease

Advances in Rehabilitation ◽

10.5114/areh.2019.89826 ◽

2019 ◽

Vol 2019 (4) ◽

pp. 43-50

Author(s):

Gabriela Szmul ◽

Jolanta Kowal ◽

Bernard Sozański ◽

Agnieszka Wiśniowska-Szurlej ◽

Agnieszka Ćwirlej-Sozańska

Keyword(s):

Quality Of Life ◽

Physical Activity ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Sociodemographic Factors ◽

The Relationship

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The Mediating Effect of Spiritual Well-Being and Quality of Life for Persons with Parkinson’s Disease in Northern Taiwan

Journal of Parkinson s Disease ◽

10.3233/jpd-212764 ◽

2021 ◽

pp. 1-12

Author(s):

Shu-Fen Chiu ◽

Yih-Ru Wu ◽

Pei-Kwei Tsay ◽

Yi-Chen Chiu

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Well Being ◽

Mediating Effect ◽

Disease Characteristics ◽

Spiritual Well Being ◽

Spiritual Self ◽

The Relationship

Background: Parkinson’s disease (PD), a degenerative disease with irreversible motor dysfunction, impacts patients’ quality of life (QoL). Spirituality can provide a sense of hope and meaning when individuals are faced with adverse life events, such as a diagnosis of PD. However, few studies have examined the relationship between spiritual well-being and QoL for persons with PD. Objective: To explore the relationships between the disease characteristics, spirituality and QoL for persons with PD, and verify the mediating effects of spirituality on the relationship. Methods: This cross-sectional study recruited patients with PD (n = 110) by convenience sampling from a neurological clinic in northern Taiwan. Variables were measured using the Spirituality Index of Well-Being Chinese version (SIWB-C) and the 39-item Parkinson’s disease Quality of Life Questionnaire Chinese version (PDQ-39-C) self-report questionnaires. Descriptive analysis and linear hierarchical regression were conducted to examine the studied variables and explore the mediating effect of spiritual wellbeing. Results: Those whose scores were significantly better in PDQ-39 were younger, employed, with shorter disease duration and less severe condition with better functioning on their early stages and lower LEDD; additionally, those who had better quality of life also experienced better spiritual wellbeing than the counterparts. The regression model demonstrated spiritual self-efficacy had mediating effects between disease characteristics and QoL, explaining 69.8%of the variance (adjusted R 2 = 65.3%). Conclusion: The results can be the references for future strategies and interventions, focusing on increasing spiritual self-efficacy and reducing the impact of disease severity to improve QoL for persons with PD.

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