The micro-thermoelectric-generator based on combustion of hydrogen and oxygen was designed. With the application of general finite reaction rate model in CFD software of FLUENT, the effect of inlet parameters on the highest temperature difference between the hot and cold plate of the generator was studied. Results show that, the temperature in the heating and cooling channel of the micro-thermoelectric-generator is uniform; With the increasing of inlet reactant temperature, the highest temperature difference increases, but the total efficiency of the generator decreases. Results can be used to the further design and optimization of micro-thermoelectric-generator based on hydrogen catalytic combustion.