Diurnal variation of tryptic activity in larval stage and development of proteolytic enzyme activities of malabar grouper (Epinephelus malabaricus) after hatching

Acute hemorrhagic pancreatitis in humans is thought to be perpetuated by the autolytic processes catalyzed by trypsin and lipase. This study is an integral part of our search for trypsin and lipase inhibitors to be used in the treatment of this disease.Benzethonium chloride was found to inhibit tryptic activity in vitro. The proteolytic activity of rabbit's serum was inhibited, and the inhibition was most pronounced 6 to 12 hours after the subcutaneous injection of the compound. Fibrinolysin was also inhibited in vitro but benzethonium chloride had no inhibitory action on chymotrypsin, pepsin, or lipase.Serum proteins in vitro were precipitated only with very high concentrations of the compound. No significant protein changes were observed in sera of rabbits after the subcutaneous injection of the compound.

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Proteolytic enzyme activities of macrophages and lymphocytes in neurological diseases

Journal of Neurology ◽

10.1007/bf00313926 ◽

1986 ◽

Vol 233 (6) ◽

pp. 373-375 ◽

Cited By ~ 1

Author(s):

I. Goto ◽

N. Shinno ◽

Y. Kuroiwa

Keyword(s):

Enzyme Activities ◽

Proteolytic Enzyme ◽

Neurological Diseases

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The role of amylolytic and proteolytic enzyme activities of vegetables, fruits, and edible fungi in flavor enhancement during cooking

International Journal of Gastronomy and Food Science ◽

10.1016/j.ijgfs.2020.100264 ◽

2020 ◽

Vol 22 ◽

pp. 100264

Author(s):

Saki Oosone ◽

Ayaka Kashiwaba ◽

Naoyuki Yanagihara ◽

Jun Yoshikawa ◽

Yutaka Kashiwagi ◽

...

Keyword(s):

Enzyme Activities ◽

Proteolytic Enzyme ◽

Edible Fungi

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THE SELECTIVE PROTEOLYTIC ENZYME INHIBITORY ACTION OF BENZETHONIUM CHLORIDE

Canadian Journal of Biochemistry and Physiology ◽

10.1139/o60-004 ◽

1960 ◽

Vol 38 (1) ◽

pp. 25-32 ◽

Cited By ~ 2

Author(s):

Ivan T. Beck ◽

E. Pinter ◽

R. D. McKenna ◽

H. Griff

Keyword(s):

Subcutaneous Injection ◽

Proteolytic Enzyme ◽

Inhibitory Action ◽

Hemorrhagic Pancreatitis ◽

Benzethonium Chloride ◽

Tryptic Activity ◽

High Concentrations ◽

Acute Hemorrhagic Pancreatitis ◽

Very High

Acute hemorrhagic pancreatitis in humans is thought to be perpetuated by the autolytic processes catalyzed by trypsin and lipase. This study is an integral part of our search for trypsin and lipase inhibitors to be used in the treatment of this disease.Benzethonium chloride was found to inhibit tryptic activity in vitro. The proteolytic activity of rabbit's serum was inhibited, and the inhibition was most pronounced 6 to 12 hours after the subcutaneous injection of the compound. Fibrinolysin was also inhibited in vitro but benzethonium chloride had no inhibitory action on chymotrypsin, pepsin, or lipase.Serum proteins in vitro were precipitated only with very high concentrations of the compound. No significant protein changes were observed in sera of rabbits after the subcutaneous injection of the compound.

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