The age related slow and fast contributions to the overall changes in tibialis anterior contractile features disclosed by maximal single twitch scan

2016 ◽  
Vol 66 ◽  
pp. 1-6 ◽  
Author(s):  
Claudio Orizio ◽  
Marta Cogliati ◽  
Luciano Bissolotti ◽  
Bertrand Diemont ◽  
Massimiliano Gobbo ◽  
...  
Keyword(s):  
Tibialis Anterior ◽  
Age Related ◽  
Single Twitch

scholarly journals Losing touch: age-related changes in plantar skin sensitivity, lower limb cutaneous reflex strength, and postural stability in older adults

2016 ◽  
Vol 116 (4) ◽  
pp. 1848-1858 ◽  
Author(s):  
Ryan M. Peters ◽  
Monica D. McKeown ◽  
Mark G. Carpenter ◽  
J. Timothy Inglis
Keyword(s):  
Older Adults ◽  
Lower Limb ◽  
Postural Stability ◽  
Tibialis Anterior ◽  
Tibialis Anterior Muscle ◽  
Quiet Standing ◽  
Detection Thresholds ◽  
Cutaneous Reflex ◽  
Age Related ◽  
Age Related Changes

Age-related changes in the density, morphology, and physiology of plantar cutaneous receptors negatively impact the quality and quantity of balance-relevant information arising from the foot soles. Plantar perceptual sensitivity declines with age and may predict postural instability; however, alteration in lower limb cutaneous reflex strength may also explain greater instability in older adults and has yet to be investigated. We replicated the age-related decline in sensitivity by assessing monofilament and vibrotactile (30 and 250 Hz) detection thresholds near the first metatarsal head bilaterally in healthy young and older adults. We additionally applied continuous 30- and 250-Hz vibration to drive mechanically evoked reflex responses in the tibialis anterior muscle, measured via surface electromyography. To investigate potential relationships between plantar sensitivity, cutaneous reflex strength, and postural stability, we performed posturography in subjects during quiet standing without vision. Anteroposterior and mediolateral postural stability decreased with age, and increases in postural sway amplitude and frequency were significantly correlated with increases in plantar detection thresholds. With 30-Hz vibration, cutaneous reflexes were observed in 95% of young adults but in only 53% of older adults, and reflex gain, coherence, and cumulant density at 30 Hz were lower in older adults. Reflexes were not observed with 250-Hz vibration, suggesting this high-frequency cutaneous input is filtered out by motoneurons innervating tibialis anterior. Our findings have important implications for assessing the risk of balance impairment in older adults.

Age-related Alterations of Apoptosis in Ischemic-reperfused Rat Tibialis Anterior and Soleus Muscles

2003 ◽  
Vol 16 (4) ◽  
pp. 291
Author(s):  
Youn Kyoung Seo ◽  
Chae Soo Shin ◽  
Jong Heon Kim ◽  
Young June You ◽  
Doo Jin Paik
Keyword(s):  
Tibialis Anterior ◽  
Age Related

scholarly journals Age-Associated Changes in the Spectral and Statistical Parameters of Surface Electromyogram ofTibialis Anterior

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Ariba Siddiqi ◽  
Sridhar Poosapadi Arjunan ◽  
Dinesh Kant Kumar
Keyword(s):  
Muscle Strength ◽  
Tibialis Anterior ◽  
The Elderly ◽  
Voluntary Contraction ◽  
Maximal Power ◽  
Statistical Parameters ◽  
Surface Electromyogram ◽  
Age Related ◽  
Power Spectral ◽  
Different Levels

Age-related neuromuscular change of Tibialis Anterior (TA) is a leading cause of muscle strength decline among the elderly. This study has established the baseline for age-associated changes in sEMG of TA at different levels of voluntary contraction. We have investigated the use of Gaussianity and maximal power of the power spectral density (PSD) as suitable features to identify age-associated changes in the surface electromyogram (sEMG). Eighteen younger (20–30 years) and 18 older (60–85 years) cohorts completed two trials of isometric dorsiflexion at four different force levels between 10% and 50% of the maximal voluntary contraction. Gaussianity and maximal power of the PSD of sEMG were determined. Results show a significant increase in sEMG’s maximal power of the PSD and Gaussianity with increase in force for both cohorts. It was also observed that older cohorts had higher maximal power of the PSD and lower Gaussianity. These age-related differences observed in the PSD and Gaussianity could be due to motor unit remodelling. This can be useful for noninvasive tracking of age-associated neuromuscular changes.

Altered response of protein synthesis to nutritional state and endurance training in old rats

1995 ◽  
Vol 268 (2) ◽  
pp. E328-E335 ◽  
Author(s):  
L. Mosoni ◽  
M. C. Valluy ◽  
B. Serrurier ◽  
J. Prugnaud ◽  
C. Obled ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Tibialis Anterior ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Marked Change ◽  
Treadmill Running ◽  
Liver Protein ◽  
Age Related ◽  
Old Rats ◽  
The Impact

This study was undertaken to determine whether the loss of muscle protein mass during aging could be explained by a reduced sensitivity of muscle protein synthesis to feeding and exercise. Male Wistar rats aged 12 and 24 mo were exercised by treadmill running for 4 mo. Protein synthesis was measured by the flooding dose method in tibialis anterior, soleus, and liver of conscious rested, trained rats and age-matched controls in the postprandial or in the postabsorptive state. No marked change with age could be detected in basal muscle protein synthesis. In contrast, protein synthesis was stimulated in adult but not in old rats by feeding in tibialis anterior and by exercise in soleus. In liver, protein synthesis was not modified by age but was stimulated by feeding and by exercise, which improved the response to feeding. We conclude that the impact of nutrition on muscle protein synthesis is blunted in old age, which could contribute to the age-related loss of nutrition-sensitive muscle proteins.

scholarly journals INTRINSIC MOTOR NEURONE EXCITABILITY IS REDUCED IN SOLEUS AND TIBIALIS ANTERIOR OF OLDER ADULTS

2021 ◽  
Author(s):  
Lucas B R Orssatto ◽  
David N Borg ◽  
Anthony J Blazevich ◽  
Raphael L Sakugawa ◽  
Anthony J Shield ◽  
...  
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Motor Unit ◽  
Tibialis Anterior ◽  
Motor Units ◽  
Motor Neurone ◽  
Age Related ◽  
Inward Currents ◽  
Motor Neurones ◽  
Intrinsic Motor

Age-related deterioration within both motor neurones and monoaminergic systems should theoretically reduce neuromodulation by weakening motor neuronal persistent inward current (PIC) strength. However, this assumption remains untested. Surface electromyographic signals were collected using two 32-channel electrode matrices placed on soleus and tibialis anterior of 25 older adults (70±4years) and 17 young adults (29±5 years) to investigate motor unit discharge behaviours. Participants performed triangular-shaped plantar and dorsiflexion contractions to 20% of maximum torque at a rise-decline rate of 2%/s of each participant's maximal torque. Pairwise and composite paired-motor unit analyses were adopted to calculate delta frequency (ΔF) and estimate PIC amplitudes. ΔF has been used to differentiate between the effects of synaptic excitation and intrinsic motor neuronal properties and is assumed to be proportional to PIC amplitude. The results show that soleus and tibialis anterior motor units in older adults had lower ΔFs when calculated with the pairwise (-0.99 and -1.29 pps, respectively) or composite (-1.65 and -2.26 pps, respectively) methods. Older adults' motor units discharged at lower rates (-2.14 and -2.03 pps, respectively) and were recruited at lower torque levels (-1.50 and -2.06% of maximum, respectively) than young adults. These results demonstrate reduced intrinsic motor neurone excitability during low-force contractions in older adults, likely mediated by decreases in the strength of persistent inward currents. Our findings might be explained by deterioration in the motor neurones or monoaminergic systems, and could contribute to the decline in motor function during ageing; these assumptions should be explicitly tested in future investigations.

Age-related Alterations of Bcl-2 and Bax Immunoreactivities in the Ischemic-reperfused Tibialis Anterior and Soleus Muscles of the Rats

2003 ◽  
Vol 16 (4) ◽  
pp. 301
Author(s):  
Youn Kyoung Seo ◽  
Chae Soo Shin ◽  
Jong Heon Kim ◽  
Young June You ◽  
Doo Jin Paik
Keyword(s):  
Tibialis Anterior ◽  
Age Related

Motor unit firing rates and contractile properties in tibialis anterior of young and old men

1999 ◽  
Vol 87 (2) ◽  
pp. 843-852 ◽  
Author(s):  
Denise M. Connelly ◽  
Charles L. Rice ◽  
Martin R. Roos ◽  
Anthony A. Vandervoort
Keyword(s):  
Motor Unit ◽  
Tibialis Anterior ◽  
Tibialis Anterior Muscle ◽  
Young Men ◽  
Contractile Properties ◽  
Firing Rates ◽  
Twitch Contraction ◽  
Age Related ◽  
Motor Unit Firing ◽  
Old Men

The effects of aging on motoneuron firing rates and muscle contractile properties were studied in tibialis anterior muscle by comparing results from six young (20.8 ± 0.8 yr) and six old men (82.0 ± 1.7 yr). For each subject, data were collected from repeated tests over a 2-wk period. Contractile tests included maximal voluntary contraction (MVC) with twitch interpolation and stimulated twitch contractions. The old men had 26% lower MVC torque ( P < 0.01) than did the young men, but percent activation was not different (99.1 and 99.3%, respectively). Twitch contraction durations were 23% longer ( P < 0.01) in the old compared with the young men. During a series of repeated brief steady-state contractions at 10, 25, 50, 75, and 100% MVC, motor unit firing rates were recorded. Results from ∼950 motor unit trains in each subject group indicated that at all relative torque levels mean firing rates were 30–35% lower ( P < 0.01) in the old subjects. Comparisons between young and old subjects’ mean firing rates at each of 10%, 50%, and MVC torques and their corresponding mean twitch contraction duration yielded a range of moderate-to-high correlations ( r = −0.67 to −0.84). That lower firing rates were matched to longer twitch contraction durations in the muscle of old men, and relatively higher firing rates were matched with shorter contraction times from the young men, indirectly supports the neuromuscular age-related remodeling principle.

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