Mature dendritic cell density is affected by smoking habit, lesion size, and epithelial dysplasia in oral leukoplakia samples

Recently, photothermal-immuno synergistic therapy under mild temperature (~ 45 °C) has got broad interest in cancer treatment. Inhibition the intratumorally HSPs production is the key to accomplish highly efficient and mild photothermal therapy. In this work, we developed biomimetic nanoterminators with mature DCs functions by coating the mature dendritic cell membrane on photothermal nanoagents. As-prepared nanoterminators could automatically locate on T cell in the complex tumor-immune microenvironment and promote the T cells proliferation, activation and cytokine secretion, which could not only inhibit the expression of heat shock proteins to cooperate on highly efficient mild photothermal therapy (~42°C), but also promote tumor apoptosis during the treatment. More importantly, this nanoterminator could serve as vaccine to trigger anti-tumor immune response of the whole body, which would be promising to long-life tumor inhibition and termination.

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FRET microscopy autologous tumor lysate processing in mature dendritic cell vaccine therapy

Journal of Translational Medicine ◽

10.1186/1479-5876-8-52 ◽

2010 ◽

Vol 8 (1) ◽

pp. 52 ◽

Cited By ~ 3

Author(s):

Laura Fiammenghi ◽

Valentina Ancarani ◽

Tilman Rosales ◽

Jay R Knutson ◽

Massimiliano Petrini ◽

...

Keyword(s):

Dendritic Cell ◽

Dendritic Cell Vaccine ◽

Vaccine Therapy ◽

Cell Vaccine ◽

Autologous Tumor ◽

Mature Dendritic Cell ◽

Tumor Lysate

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Immunohistochemical Expression of Podoplanin in Clinical Variants of Oral Leukoplakia and Its Correlation With Epithelial Dysplasia

Applied Immunohistochemistry & Molecular Morphology ◽

10.1097/pai.0000000000000383 ◽

2016 ◽

pp. 1 ◽

Cited By ~ 1

Author(s):

Brendan D’souza ◽

Ramakant Nayak ◽

Vijayalakshmi S. Kotrashetti

Keyword(s):

Oral Leukoplakia ◽

Epithelial Dysplasia ◽

Immunohistochemical Expression ◽

Clinical Variants

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MicroRNA expression profile of mature dendritic cell in chronic rhinosinusitis

Inflammation Research ◽

10.1007/s00011-015-0870-5 ◽

2015 ◽

Vol 64 (11) ◽

pp. 885-893 ◽

Cited By ~ 13

Author(s):

Zu-Xia Ma ◽

Xi Tan ◽

Yang Shen ◽

Xia Ke ◽

Yu-Cheng Yang ◽

...

Keyword(s):

Dendritic Cell ◽

Chronic Rhinosinusitis ◽

Expression Profile ◽

Microrna Expression ◽

Mature Dendritic Cell ◽

Microrna Expression Profile

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Silver Binding Nucleolar Organizer Regions Dots in Oral Leukoplakia with Epithelial Dysplasia and Oral Squamous Cell Carcinoma: An In Vivo Study

ISRN Dentistry ◽

10.1155/2014/479187 ◽

2014 ◽

Vol 2014 ◽

pp. 1-4 ◽

Cited By ~ 1

Author(s):

Fahad Mansoor Samadi ◽

Bastain Thattil Sebastian ◽

Anil Singh ◽

Shaleen Chandra ◽

Shadab Mohammad ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Nucleolar Organizer ◽

Oral Leukoplakia ◽

Epithelial Dysplasia ◽

Nucleolar Organizer Regions ◽

Normal Oral Mucosa

Silver binding nucleolar organizer regions (AgNOR) in normal oral mucosa (NOM), oral leukoplakia with epithelial dysplasia (ED), and oral squamous cell carcinoma (OSCC) were studied. The mean AgNOR count per nucleus increased from NOM to ED to OSCC. Tissue showing ED in oral leukoplakia and OSCC cases showed higher counts, wider scatter, and smaller size of AgNOR dots in the nuclei. The study seems to suggest that time method has some potential in distinguishing between NOM and oral leukoplakia with ED and OSCC. Studies of larger numbers are needed to arrive at more substantial conclusions.

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