Clinically Asymptomatic Patients Show a High Bacterial Colonization Rate of Osteosynthetic Implants Around the Knee but Not the Hip

2019 ◽  
Vol 34 (8) ◽  
pp. 1761-1766 ◽  
Author(s):  
Michael Fuchs ◽  
Sabrina Kinzel ◽  
Clemens Gwinner ◽  
Carsten Perka ◽  
Nora Renz ◽  
...  
Keyword(s):  
Bacterial Colonization ◽  
Colonization Rate ◽  
Asymptomatic Patients

Influence of Chlorhexidine in Ethanol and in Isopropanol on the Bacterial Colonization of the Umbilicus of Newborns

1985 ◽  
Vol 6 (5) ◽  
pp. 186-188 ◽  
Author(s):  
B. Nyström ◽  
S. Bygdeman ◽  
A. Henningsson ◽  
R. Tunell ◽  
U. Berg
Keyword(s):  
Bacterial Colonization ◽  
Experimental Models ◽  
Daily Treatment ◽  
Colonization Rate ◽  
Practical Reasons ◽  
Infection Rates ◽  
Treatment Groups

AbstractThe effect of daily treatment with 0.5% Chlorhexidine in 70% ethanol and in 70% isopropanol, respectively, on navel colonization and on rates of infection in newborns has been studied in 438 infants in two maternity wards during a 3-month period. In spite of isopropanol being reported as a more efficient skin disinfectant than ethanol in several experimental models, no significant differences were seen in the frequency of navel colonization or in infection rates between the two treatment groups. The colonization rate with S. aureus was lower in this than in an earlier investigation on navel disinfection with Chlorhexidine in ethanol performed in the same wards. This may reflect a progressive effectiveness of the treatment due to fewer S. aureus sources in the nursery. For practical reasons we continue to recommend daily navel disinfection with 0.5% Chlorhexidine in 70% ethanol on healthy newborns in hospital nurseries.

scholarly journals High Frequency of Low-Virulent Microorganisms Detected by Sonication of Implanted Pulse Generators: So What?

2021 ◽  
pp. 1-6
Author(s):  
Philipp Spindler ◽  
Katharina Faust ◽  
Tobias Finger ◽  
Gerd-Helge Schneider ◽  
Simon Bayerl ◽  
...  
Keyword(s):  
Bacterial Colonization ◽  
Clinical Signs ◽  
Microbial Colonization ◽  
Associated Bacteria ◽  
Pulse Generators ◽  
Replacement Surgery ◽  
Asymptomatic Patients ◽  
Cutibacterium Acnes ◽  
The Impact

<b><i>Introduction:</i></b> Deep brain stimulation (DBS) has become a well-established treatment modality for a variety of conditions over the last decades. Multiple surgeries are an essential part in the postoperative course of DBS patients if nonrechargeable implanted pulse generators (IPGs) are applied. So far, the rate of subclinical infections in this field is unknown. In this prospective cohort study, we used sonication to evaluate possible microbial colonization of IPGs from replacement surgery. <b><i>Methods:</i></b> All consecutive patients undergoing IPG replacement between May 1, 2019 and November 15, 2020 were evaluated. The removed hardware was investigated using sonication to detect biofilm-associated bacteria. Demographic and clinical data were analyzed. <b><i>Results:</i></b> A total of 71 patients with a mean (±SD) of 64.5 ± 15.3 years were evaluated. In 23 of these (i.e., 32.4%) patients, a positive sonication culture was found. In total, 25 microorganisms were detected. The most common isolated microorganisms were <i>Cutibacterium acnes</i> (formerly known as <i>Propionibacterium acnes</i>) (68%) and coagulase-negative <i>Staphylococci</i> (28%). Within the follow-up period (5.2 ± 4.3 months), none of the patients developed a clinical manifest infection. <b><i>Discussions/Conclusions:</i></b> Bacterial colonization of IPGs without clinical signs of infection is common but does not lead to manifest infection. Further larger studies are warranted to clarify the impact of low-virulent pathogens in clinically asymptomatic patients.

scholarly journals Bacterial Colonization of Particles: Growth and Interactions

2003 ◽  
Vol 69 (6) ◽  
pp. 3500-3509 ◽  
Author(s):  
Hans-Peter Grossart ◽  
Thomas Ki�rboe ◽  
Kam Tang ◽  
Helle Ploug
Keyword(s):  
Population Density ◽  
Antibiotic Production ◽  
Interspecific Interactions ◽  
Bacterial Colonization ◽  
Hydrolytic Activity ◽  
Inhibitory Effect ◽  
Colonization Rate ◽  
Small Scale ◽  
Bacterial Strains ◽  
Marine Particles

ABSTRACT Marine particles in the ocean are exposed to diverse bacterial communities, and colonization and growth of attached bacteria are important processes in the degradation and transformation of the particles. In an earlier study, we showed that the initial colonization of model particles by individual bacterial strains isolated from marine aggregates was a function of attachment and detachment. In the present study, we have investigated how this colonization process was further affected by growth and interspecific interactions among the bacteria. Long-term incubation experiments showed that growth dominated over attachment and detachment after a few hours in controlling the bacterial population density on agar particles. In the absence of grazing mortality, this growth led to an equilibrium population density consistent with the theoretical limit due to oxygen diffusion. Interspecific interaction experiments showed that the presence of some bacterial strains (“residents”) on the agar particles either increased or decreased the colonization rate of other strains (“newcomers”). Comparison between an antibiotic-producing strain and its antibiotic-free mutant showed no inhibitory effect on the newcomers due to antibiotic production. On the contrary, hydrolytic activity of the antibiotic-producing strain appeared to benefit the newcomers and enhance their colonization rate. These results show that growth- and species-specific interactions have to be taken into account to adequately describe bacterial colonization of marine particles. Changes in colonization pattern due to such small-scale processes may have profound effects on the transformation and fluxes of particulate matter in the ocean.

Case Example: Adjacent Segment Disease: What Is It, and How Is It Rated?

2011 ◽  
Vol 16 (2) ◽  
pp. 8-9
Author(s):  
Marjorie Eskay-Auerbach
Keyword(s):  
Clinical Symptoms ◽  
Lumbar Fusion ◽  
Adjacent Segment Degeneration ◽  
Adjacent Segment Disease ◽  
Adjacent Segment ◽  
Disc Space Narrowing ◽  
Disc Disease ◽  
Disc Space ◽  
Radiographic Findings ◽  
Asymptomatic Patients

Abstract The incidence of cervical and lumbar fusion surgery has increased in the past twenty years, and during follow-up some of these patients develop changes at the adjacent segment. Recognizing that adjacent segment degeneration and disease may occur in the future does not alter the rating for a cervical or lumbar fusion at the time the patient's condition is determined to be at maximum medical improvement (MMI). The term adjacent segment degeneration refers to the presence of radiographic findings of degenerative disc disease, including disc space narrowing, instability, and so on at the motion segment above or below a cervical or lumbar fusion. Adjacent segment disease refers to the development of new clinical symptoms that correspond to these changes on imaging. The biomechanics of adjacent segment degeneration have been studied, and, although the exact mechanism is uncertain, genetics may play a role. Findings associated with adjacent segment degeneration include degeneration of the facet joints with hypertrophy and thickening of the ligamentum flavum, disc space collapse, and translation—but the clinical significance of these radiographic degenerative changes remains unclear, particularly in light of the known presence of abnormal findings in asymptomatic patients. Evaluators should not rate an individual in anticipation of the development of changes at the level above a fusion, although such a development is a recognized possibility.

Are asymptomatic patients likely to benefit from carotid interventions?

2006 ◽  
Vol 39 (2) ◽  
pp. 15
Author(s):  
Barry T. Katzen ◽  
Trevor Cleveland
Keyword(s):  
Asymptomatic Patients
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