Perioperative Selective Serotonin Reuptake Inhibitor Use Is Associated With an Increased Risk of Transfusion in Total Hip and Knee Arthroplasty

2019 ◽  
Vol 34 (12) ◽  
pp. 2898-2902
Author(s):  
Elshaday S. Belay ◽  
Colin T. Penrose ◽  
Sean P. Ryan ◽  
Michael A. Bergen ◽  
Michael P. Bolognesi ◽  
...  
Keyword(s):  
Selective Serotonin Reuptake Inhibitor ◽  
Reuptake Inhibitor ◽  
Knee Arthroplasty ◽  
Serotonin Reuptake ◽  
Selective Serotonin ◽  
Serotonin Reuptake Inhibitor ◽  
Total Hip ◽  
Increased Risk ◽  
Hip And Knee Arthroplasty

scholarly journals Selective serotonin reuptake inhibitor treatment in the UK: Risk of relapse or recurrence of depression

2000 ◽  
Vol 177 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Ami J. Claxton ◽  
Zhiming Li ◽  
Jan McKendrick
Keyword(s):  
Selective Serotonin Reuptake Inhibitor ◽  
Reuptake Inhibitor ◽  
Serotonin Reuptake ◽  
Treatment Guidelines ◽  
Prescribing Patterns ◽  
Selective Serotonin ◽  
Serotonin Reuptake Inhibitor ◽  
Increased Risk ◽  
The Impact ◽  
Risk Of Relapse

BackgroundPatients with depression are often not prescribed antidepressants for an adequate period of time.AimsThe impact of antidepressant prescribing patterns on the risk of relapse or recurrence of depression is examined.MethodThe Medi Plus UK Primary Care Database was used to identify patients treated for depression with a selective serotonin reuptake inhibitor (SSRI). Records were used to construct hierarchical prescription patterns (less than 120 days, switching/augmentation, upward titration, or stable use) as indicators for the occurrence of relapse or recurrence of depression.ResultsPatients with stable use experienced the lowest risk of relapse or recurrence. Factors significantly associated with increased risk include prior use of anxiolytic medications, more comorbid conditions and younger age.ConclusionsThe SSRI prescription pattern most consistent with recommended depression treatment guidelines was associated with the lowest risk of relapse or recurrence.

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