P5.11 PROXIMAL AORTIC REMODELING IS ASSOCIATED WITH LEFT VENTRICULAR MASS AND PULSE WAVE VELOCITY IN ESSENTIAL HYPERTENSION

2014 ◽  
Vol 8 (4) ◽  
pp. 145
Author(s):  
F. Tosello ◽  
D. Leone ◽  
G. Bruno ◽  
A. Ravera ◽  
L. Sabia ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Pulse Wave Velocity ◽  
Left Ventricular Mass ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Left Ventricular ◽  
Ventricular Mass ◽  
Aortic Remodeling

A new technique for study of impact of arterial elasticity on left ventricular mass in rats

1996 ◽  
Vol 270 (3) ◽  
pp. H981-H987
Author(s):  
F. Amin ◽  
N. Niederhoffer ◽  
R. Tatchum-Talom ◽  
T. Makki ◽  
J. Guillou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Elastic Modulus ◽  
Pulse Wave Velocity ◽  
Left Ventricular Mass ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Left Ventricular ◽  
New Technique ◽  
Arterial Elasticity ◽  
Ventricular Mass

We investigated possible links between left ventricular mass and central arterial elasticity in the adult spontaneously hypertensive rat (SHR) and in a subgroup of SHR in which blood pressure was normalized by chronic antihypertensive drug treatment; results were compared with those of age-matched normotensive Wistar-Kyoto rats. Two indexes of arterial elasticity, based on the measurement of aortic pressure pulse wave velocity, were used. First, the slope relating carotidofemoral pulse wave velocity to blood pressure in the phenylephrine-infused pithed preparation was used as a pressure-independent index of wall elasticity. Second, to account for hypertension- and treatment-induced aortic remodeling, elastic modulus was determined from the pulse wave velocity recorded when blood pressure reached that measured in awake animals before anesthesia and pithing, together with values for wall thickness and lumen diameter evaluated by histomorphometric analysis after in situ fixation at the same pressure. In control SHR, regression analysis of variance revealed significant correlations between left ventricular mass and both wave velocity/pressure slope and elastic modulus. Chronic antihypertensive treatment normalized all three parameters. In conclusion, this new technique provides experimental evidence of a link between left ventricular mass and central arterial elasticity.

scholarly journals Association of Aortic Arch Pulse Wave Velocity with Left Ventricular Mass and Lacunar Brain Infarcts in Hypertensive Patients: Assessment with MR Imaging

Radiology ◽  
2009 ◽  
Vol 253 (3) ◽  
pp. 681-688 ◽  
Author(s):  
Anne Brandts ◽  
Saskia G. C. van Elderen ◽  
Jos J. M. Westenberg ◽  
Jeroen van der Grond ◽  
Mark A. van Buchem ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Pulse Wave Velocity ◽  
Aortic Arch ◽  
Left Ventricular Mass ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Left Ventricular ◽  
Hypertensive Patients ◽  
Brain Infarcts ◽  
Ventricular Mass

scholarly journals Cardiovascular Organ Damage and Blood Pressure Levels Predict Adverse Events in Multiple Myeloma Patients Undergoing Carfilzomib Therapy

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 622 ◽  
Author(s):  
Giulia Bruno ◽  
Sara Bringhen ◽  
Ilaria Maffei ◽  
Andrea Iannaccone ◽  
Teresa Crea ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Multiple Myeloma ◽  
Adverse Events ◽  
Pulse Wave Velocity ◽  
Left Ventricular Mass ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Organ Damage ◽  
Left Ventricular ◽  
Ventricular Mass

Carfilzomib is a second-generation proteasome inhibitor approved for the treatment of multiple myeloma (MM). It seems to determine cardiovascular toxicity, primarily arterial hypertension. No predictive factors for cardiovascular adverse events (CVAEs) are known in patients affected by multiple myeloma treated with carfilzomib. We evaluated the role of cardiovascular organ damage parameters to predict CVAEs in MM patients taking carfilzomib. Seventy patients affected by MM were prospectively enrolled. A comprehensive cardiovascular evaluation was performed before carfilzomib therapy; they underwent a transthoracic echocardiogram and the assessment of carotid-femoral pulse wave velocity. All the patients were followed up (FU) to determine the incidence of CVAEs. The mean age was 60.3 ± 8.2, and 51% were male. The median FU was 9.3 (4.3; 20.4) months. A proportion of 33% experienced CVAEs, 91% of them had uncontrolled hypertension, 4.5% acute coronary syndrome, and 4.5% cardiac arrhythmias. Subjects with CVAEs after carfilzomib treatment had significantly higher blood pressure values, left ventricular mass (98 ± 23 vs. 85 ± 17 g/m2, p = 0.01), and pulse wave velocity (8.5 ± 1.7 vs. 7.5 ± 1.6 m/s, p = 0.02) at baseline evaluation compared to the others. Furthermore, baseline uncontrolled blood pressure, left ventricular hypertrophy, and pulse wave velocity ≥ 9 m/s were able to identify patients at higher risk of developing CVAEs during FU. These preliminary findings indicate that blood pressure control, left ventricular mass, and pulse wave velocity may predict CVAEs in MM patients treated with carfilzomib.

scholarly journals PERFORMANCE OF THE VASCULAR STIFFNESS INDICATORS AND THE PROCESS OF LEFT VENTRICLE REMODELING IN HYPERTENSIVE PATIENTS UNDER RENAL REPLACEMENT THERAPY

2019 ◽  
Vol 9 (5) ◽  
pp. 391-398
Author(s):  
E. A. Praskurnichiy ◽  
I. E. Minyukhina
Keyword(s):  
Essential Hypertension ◽  
Renal Replacement Therapy ◽  
Pulse Wave Velocity ◽  
Arterial Hypertension ◽  
Healthy Volunteers ◽  
Replacement Therapy ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Left Ventricular ◽  
Vascular Stiffness

Objective. The objective of our study was to compare the performance of vascular stiffness (VS) and the left ventricular (LV) remodeling process indicators in patients with arterial hypertension (AH) under renal replacement therapy (RRT), and patients with essential hypertension.Design and methods. 158 people were included in the study, divided into 4 comparable age groups: 32 patients receiving programmed hemodialysis (PH), 37 recipients of renal transplant (RT), 69 patients with essential AH and 20 healthy volunteers. All the patients underwent 24-hour blood pressure (BP) monitoring with an assessment of VS and central BP (SBPao) and echocardiography (EchoCG).Results. The patients under PH and after RT did not have any significant differences in the values of central and peripheral BP. Comparing the groups of patients under RRT with the group of essential AH, the office systolic (SBP) and diastolic (DBP) BP values did not differ significantly. Аlthough, at night, considerably higher DBP(n) and SBPao(n) values were detected in patients under RRT, and in the patients after RT SBP(n) and PP(n) values were also increased. An increase in the SBPao values of more than 10 m/sec was detected only in the groups of patients under RRT. In all the groups with hypertension all indicators of daily VS differed significantly from the group of healthy volunteers. PTIN (Pulse Time Index of Norm) in the studied groups had more evident differences: in the healthy volunteers it was in the range of 80-90%, in the patients with essential hypertension — 50-60%, and in the patients under PH and after RT — 20-40%. In all groups of patients with AH, the average the posterior wall thickness (PWT) of the LV and the interventricular septum thickness (IVST) were close to the upper limit of the norm. In the groups of patients with AH an increase in the relative wall thickness (RWT) of the LV was also detected. Furthermore, considerably higher the values of ILVmass, IVST were found in the group of patients on PH in comparison with the patients after RT. In addition, in all the groups of patients with AH, there was a tendency to LV spherification in comparison with the healthy volunteers, and in the group of essential AH the difference was more pronounced compared with the group under RRT.Conclusion. In the patients with arterial hypertension who undergo renal replacement therapy, higher average values of central BP, higher vascular stiffness (daily pulse wave velocity in the aorta and a longer period of pulse wave velocity increase in the aorta during the day (PTIN)) and less pronounced left ventricular spherification are recorded in comparison with the patients with essential hypertension while office BP values remained consistent.

Sign in / Sign up

Export Citation Format

Share Document