The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation

2013 ◽  
Vol 228 (2) ◽  
pp. 295-305 ◽  
Author(s):  
Smriti Murali Krishna ◽  
Anthony Dear ◽  
Jeffrey M. Craig ◽  
Paul E. Norman ◽  
Jonathan Golledge
Keyword(s):  
Dna Methylation ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Potential Role ◽  
Epigenetic Changes ◽  
Aneurysm Formation ◽  
Abdominal Aortic

The potential role of DNA methylation in the pathogenesis of abdominal aortic aneurysm

2015 ◽  
Vol 241 (1) ◽  
pp. 121-129 ◽  
Author(s):  
Bradley J. Toghill ◽  
Athanasios Saratzis ◽  
Seamus C. Harrison ◽  
Ana R. Verissimo ◽  
Eamonn B. Mallon ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Potential Role ◽  
Abdominal Aortic

Abstract: S2-17 CRITICAL ROLE OF MAST CELL CHYMASE IN MOUSE ABDOMINAL AORTIC ANEURYSM FORMATION

2009 ◽  
Vol 10 (2) ◽  
pp. e1517
Author(s):  
J Sun ◽  
J Zhang ◽  
J Lindholt ◽  
G Sukhova ◽  
P Libby ◽  
...  
Keyword(s):  
Mast Cell ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Critical Role ◽  
Aneurysm Formation ◽  
Abdominal Aortic ◽  
Mast Cell Chymase

scholarly journals Critical Role of Mast Cell Chymase in Mouse Abdominal Aortic Aneurysm Formation

Circulation ◽  
2009 ◽  
Vol 120 (11) ◽  
pp. 973-982 ◽  
Author(s):  
Jiusong Sun ◽  
Jie Zhang ◽  
Jes S. Lindholt ◽  
Galina K. Sukhova ◽  
Jian Liu ◽  
...  
Keyword(s):  
Mast Cell ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Critical Role ◽  
Aneurysm Formation ◽  
Abdominal Aortic ◽  
Mast Cell Chymase

scholarly journals The Role of Extracellular Signal-Related Kinase During Abdominal Aortic Aneurysm Formation

2012 ◽  
Vol 215 (5) ◽  
pp. 668-680.e1 ◽  
Author(s):  
Abhijit Ghosh ◽  
Paul D. DiMusto ◽  
Lauren K. Ehrlichman ◽  
Omar Sadiq ◽  
Brendan McEvoy ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Aneurysm Formation ◽  
Abdominal Aortic ◽  
Extracellular Signal

scholarly journals Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-Benzopyrene/Angiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Yingying Zhou ◽  
Jiaoni Wang ◽  
Yangjing Xue ◽  
Aili Fang ◽  
Shaoze Wu ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Macrophage Activation ◽  
Potential Role ◽  
Biological Function ◽  
Cascade Reactions ◽  
Fatal Disease ◽  
Abdominal Aortic ◽  
Activated Macrophage

Abdominal aortic aneurysm (AAA) is a fatal disease, and exposure to 3,4-benzopyrene (Bap) is closely related to the development of AAA. We have found that Bap could impair the biological function of endothelial progenitor cells (EPCs), which are associated with the occurrence of AAA. We have also demonstrated that macrophage activation plays a key role in Bap-induced AAA, but the mechanism is unknown. Here, we used a mouse lncRNA array to investigate the expression signatures of lncRNAs and mRNAs in Bap-activated macrophage. A total of 457 lncRNAs and 219 mRNAs were found to be differentially expressed. The function of differential mRNAs was determined by pathway and Gene Ontology analysis. Eight pathways associated with inflammation were upregulated, and seven pathways including cell apoptosis were downregulated. It was worth noting that AGE-RAGE pathway, which was involved in Bap-induced EPC dysfunction, was significantly upregulated in Bap-activated macrophage and may contribute to AAA formation. Thus, lncRNAs may exert a key role in activated macrophages and intervene the core lncRNAs and may inhibit the occurrence of a series of cascade reactions in the macrophages, which may provide potential targets for AAA caused by smoking.

Sign in / Sign up

Export Citation Format

Share Document