scholarly journals Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder

BBA Clinical ◽  
2016 ◽  
Vol 5 ◽  
pp. 151-158 ◽  
Author(s):  
Noriko Yoshimi ◽  
Takashi Futamura ◽  
Keiji Kakumoto ◽  
Alireza M. Salehi ◽  
Carl M. Sellgren ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Amino Acid ◽  
Citric Acid ◽  
Amino Acid Metabolism ◽  
Citric Acid Cycle ◽  
Acid Metabolism ◽  
Urea Cycle ◽  
Acid Cycle ◽  
Metabolomics Analysis

498-P: Resistance Exercise Rapidly Alters Citric Acid Cycle and Amino Acid Metabolism in Skeletal Muscle

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 498-P
Author(s):  
MARK W. PATAKY ◽  
ARATHI PRABHA KUMAR ◽  
KATHERINE KLAUS ◽  
K. SREEKUMARAN NAIR
Keyword(s):  
Skeletal Muscle ◽  
Amino Acid ◽  
Citric Acid ◽  
Resistance Exercise ◽  
Amino Acid Metabolism ◽  
Citric Acid Cycle ◽  
Acid Metabolism ◽  
Acid Cycle

scholarly journals Conversion of glutamate into aspartate in guinea-pig cerebral-cortex slices

1968 ◽  
Vol 107 (1) ◽  
pp. 109-111 ◽  
Author(s):  
Gerald Simon ◽  
M. M. Cohen ◽  
J. F. Berry
Keyword(s):  
Cerebral Cortex ◽  
Amino Acid ◽  
Citric Acid ◽  
Guinea Pig ◽  
Amino Acid Metabolism ◽  
Citric Acid Cycle ◽  
Acid Metabolism ◽  
Acid Cycle ◽  
Cortex Slices

1. When guinea-pig cerebral-cortex slices were incubated with [U−14C]glutamate as substrate, the specific radioactivities of the citric acid-cycle intermediates were lower than that of the aspartate isolated from the same vessels. 2. Aspartate was significantly labelled when [5−14C]glutamate was used as substrate and the aspartate contained almost no label when [1−14C]glutamate was present as substrate. 3. When specifically labelled glutamate was used as substrate, the label was found in the isolated aspartate in the position that would be predicted by citric acid-cycle mechanisms. 4. The results are consistent with the theory of ‘compartmentation’ of amino acid metabolism.

scholarly journals Oxidative Stress and Mitochondrial Dysfunction in Human Diseases: Pathophysiology, Predictive Biomarkers, Therapeutic

Biomolecules ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1558
Author(s):  
Chia-Jung Li
Keyword(s):  
Oxidative Stress ◽  
Fatty Acid ◽  
Amino Acid ◽  
Citric Acid ◽  
Oxidative Phosphorylation ◽  
Citric Acid Cycle ◽  
Acid Metabolism ◽  
Predictive Biomarkers ◽  
Acid Cycle ◽  
Cellular Processes

Mitochondria are important sites for a variety of cellular processes, including amino acid and fatty acid metabolism, the citric acid cycle, nitrogen metabolism, and oxidative phosphorylation to produce ATP [...]

Glucagon receptor signaling is not required for N-carbamoyl glutamate- and l-citrulline-induced ureagenesis in mice

2020 ◽  
Vol 318 (5) ◽  
pp. G912-G927
Author(s):  
Katrine D. Galsgaard ◽  
Jens Pedersen ◽  
Sasha A. S. Kjeldsen ◽  
Marie Winther-Sørensen ◽  
Elena Stojanovska ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Urea Cycle ◽  
Receptor Signaling ◽  
Glucagon Receptor ◽  
Acetylglutamate Synthase

Hepatic ureagenesis is essential in amino acid metabolism and is importantly regulated by glucagon, but the exact mechanism is unclear. With the aim to identify the steps whereby glucagon both acutely and chronically regulates ureagenesis, we here show, contrary to our hypothesis, that glucagon receptor-mediated activation of ureagenesis is not required when N-acetylglutamate synthase activity and/or N-acetylglutamate levels are sufficient to activate the first step of the urea cycle in vivo.

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