Inhibition of vascular endothelial growth factor receptor tyrosine kinases impairs adipose tissue development in mouse models of obesity

2007 ◽  
Vol 1770 (9) ◽  
pp. 1369-1373 ◽  
Author(s):  
H.R. Lijnen ◽  
B. Van Hoef ◽  
D. Kemp ◽  
D. Collen
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Adipose Tissue ◽  
Growth Factor ◽  
Mouse Models ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Adipose Tissue Development ◽  
Endothelial Growth Factor

scholarly journals Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6

2015 ◽  
Vol 35 (4) ◽  
Author(s):  
Yvonne Volz ◽  
David Koschut ◽  
Alexandra Matzke-Ogi ◽  
Marina S. Dietz ◽  
Christos Karathanasis ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Binding Affinities ◽  
Direct Binding ◽  
Endothelial Growth Factor ◽  
Hepatocyte Growth

CD44v6 is a co-receptor for the receptor tyrosine kinases Met and VEGFR-2 (vascular endothelial growth factor receptor 2). The binding of these RTKs (receptor tyrosine kinases) to their ligands on cells requires CD44v6. Pull-downs assays show direct binding between these entities. Binding affinities were measured by several biophysical methods.

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