The Discovery of Novel Vascular Endothelial Growth Factor Receptor Tyrosine Kinases Inhibitors: Pharmacophore Modeling, Virtual Screening and Docking Studies

2007 ◽  
Vol 69 (3) ◽  
pp. 204-211 ◽  
Author(s):  
Hui Yu ◽  
Zhanli Wang ◽  
Liangren Zhang ◽  
Jufeng Zhang ◽  
Qian Huang
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Virtual Screening ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Growth Factor Receptor ◽  
Pharmacophore Modeling ◽  
Docking Studies ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6

2015 ◽  
Vol 35 (4) ◽  
Author(s):  
Yvonne Volz ◽  
David Koschut ◽  
Alexandra Matzke-Ogi ◽  
Marina S. Dietz ◽  
Christos Karathanasis ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Tyrosine Kinases ◽  
Receptor Tyrosine Kinases ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Binding Affinities ◽  
Direct Binding ◽  
Endothelial Growth Factor ◽  
Hepatocyte Growth

CD44v6 is a co-receptor for the receptor tyrosine kinases Met and VEGFR-2 (vascular endothelial growth factor receptor 2). The binding of these RTKs (receptor tyrosine kinases) to their ligands on cells requires CD44v6. Pull-downs assays show direct binding between these entities. Binding affinities were measured by several biophysical methods.

Sign in / Sign up

Export Citation Format

Share Document