Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6

Bioscience Reports ◽

10.1042/bsr20150093 ◽

2015 ◽

Vol 35 (4) ◽

Author(s):

Yvonne Volz ◽

David Koschut ◽

Alexandra Matzke-Ogi ◽

Marina S. Dietz ◽

Christos Karathanasis ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Binding Affinities ◽

Direct Binding ◽

Endothelial Growth Factor ◽

Hepatocyte Growth

CD44v6 is a co-receptor for the receptor tyrosine kinases Met and VEGFR-2 (vascular endothelial growth factor receptor 2). The binding of these RTKs (receptor tyrosine kinases) to their ligands on cells requires CD44v6. Pull-downs assays show direct binding between these entities. Binding affinities were measured by several biophysical methods.

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Inhibitors targeting hepatocyte growth factor receptor and vascular endothelial growth factor receptor tyrosine kinases

Expert Opinion on Therapeutic Patents ◽

10.1517/13543776.16.5.713 ◽

2006 ◽

Vol 16 (5) ◽

pp. 713-718 ◽

Author(s):

Jean Cui

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Hepatocyte Growth Factor ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Hepatocyte Growth Factor Receptor ◽

Endothelial Growth Factor ◽

Hepatocyte Growth

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KRN951, a highly potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, has antitumor activities and affects functional vascular properties

Urologic Oncology Seminars and Original Investigations ◽

10.1016/j.urolonc.2007.03.023 ◽

2007 ◽

Vol 25 (4) ◽

pp. 359-360

Author(s):

Gregory Metzger

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Potent Inhibitor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Antitumor Activities ◽

Endothelial Growth Factor

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SKLB610: A Novel Potential Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases Inhibits Angiogenesis and Tumor Growth in Vivo

Cellular Physiology and Biochemistry ◽

10.1159/000329978 ◽

2011 ◽

Vol 27 (5) ◽

pp. 565-574 ◽

Author(s):

Zhi-Xing Cao ◽

Ren-Lin Zheng ◽

Hong-Jun Lin ◽

Shi-Dong Luo ◽

Yan Zhou ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tumor Growth ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Potential Inhibitor ◽

Endothelial Growth Factor

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Inhibition of vascular endothelial growth factor receptor tyrosine kinases impairs adipose tissue development in mouse models of obesity

Biochimica et Biophysica Acta (BBA) - General Subjects ◽

10.1016/j.bbagen.2007.06.001 ◽

2007 ◽

Vol 1770 (9) ◽

pp. 1369-1373 ◽

Author(s):

H.R. Lijnen ◽

B. Van Hoef ◽

D. Kemp ◽

D. Collen

Keyword(s):

Vascular Endothelial Growth Factor ◽

Adipose Tissue ◽

Growth Factor ◽

Mouse Models ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Adipose Tissue Development ◽

Endothelial Growth Factor

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The Discovery of Novel Vascular Endothelial Growth Factor Receptor Tyrosine Kinases Inhibitors: Pharmacophore Modeling, Virtual Screening and Docking Studies

Chemical Biology & Drug Design ◽

10.1111/j.1747-0285.2007.00488.x ◽

2007 ◽

Vol 69 (3) ◽

pp. 204-211 ◽

Author(s):

Hui Yu ◽

Zhanli Wang ◽

Liangren Zhang ◽

Jufeng Zhang ◽

Qian Huang

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Virtual Screening ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Growth Factor Receptor ◽

Pharmacophore Modeling ◽

Docking Studies ◽

Vascular Endothelial ◽

Endothelial Growth Factor

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KRN951, a Highly Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, Has Antitumor Activities and Affects Functional Vascular Properties

Cancer Research ◽

10.1158/0008-5472.can-05-4290 ◽

2006 ◽

Vol 66 (18) ◽

pp. 9134-9142 ◽

Author(s):

Kazuhide Nakamura ◽

Eri Taguchi ◽

Toru Miura ◽

Atsushi Yamamoto ◽

Kazumi Takahashi ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Potent Inhibitor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Antitumor Activities ◽

Endothelial Growth Factor

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Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases.

International Journal of Oncology ◽

10.3892/ijo.16.3.445 ◽

2000 ◽

Author(s):

L Xu ◽

J Yoneda ◽

C Herrera ◽

J Wood ◽

J J Killion ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Potent Inhibitor ◽

Growth Factor Receptor ◽

Malignant Ascites ◽

Vascular Endothelial ◽

Human Ovarian Carcinoma ◽

Endothelial Growth Factor

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Nonclinical Antiangiogenesis and Antitumor Activities of Axitinib (AG-013736), an Oral, Potent, and Selective Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases 1, 2, 3

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-08-0652 ◽

2008 ◽

Vol 14 (22) ◽

pp. 7272-7283 ◽

Author(s):

Dana D. Hu-Lowe ◽

Helen Y. Zou ◽

Maren L. Grazzini ◽

Max E. Hallin ◽

Grant R. Wickman ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Growth Factor Receptor ◽

Selective Inhibitor ◽

Vascular Endothelial ◽

Antitumor Activities ◽

Endothelial Growth Factor

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Inhibition of Growth and Metastasis of Human Pancreatic Cancer Growing in Nude Mice by PTK 787/ZK222584, an Inhibitor of the Vascular Endothelial Growth Factor Receptor Tyrosine Kinases

Cancer Biotherapy & Radiopharmaceuticals ◽

10.1089/108497801753354267 ◽

2001 ◽

Vol 16 (5) ◽

pp. 359-370 ◽

Author(s):

Carmen C. Solorzano ◽

Cheryl H. Baker ◽

Christiane J. Bruns ◽

Jerald J. Killion ◽

Lee M. Ellis ◽

...

Keyword(s):

Pancreatic Cancer ◽

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Growth Factor Receptor ◽

Human Pancreatic Cancer ◽

Vascular Endothelial ◽

Inhibition Of Growth ◽

Endothelial Growth Factor

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Detection and Quantification of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases in Primary Human Endothelial Cells

Methods in Molecular Biology - VEGF Signaling ◽

10.1007/978-1-4939-2917-7_4 ◽

2015 ◽

pp. 49-65 ◽

Author(s):

Gareth W. Fearnley ◽

Stephen B. Wheatcroft ◽

Sreenivasan Ponnambalam

Keyword(s):

Vascular Endothelial Growth Factor ◽

Endothelial Cells ◽

Growth Factor ◽

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Human Endothelial Cells ◽

Endothelial Growth Factor ◽

Detection And Quantification

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