scholarly journals Cyclic phosphatidic acid and lysophosphatidic acid induce hyaluronic acid synthesis via CREB transcription factor regulation in human skin fibroblasts

2014 ◽  
Vol 1841 (9) ◽  
pp. 1256-1263 ◽  
Author(s):  
Katsura Maeda-Sano ◽  
Mari Gotoh ◽  
Toshiro Morohoshi ◽  
Takao Someya ◽  
Hiromu Murofushi ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Hyaluronic Acid ◽  
Phosphatidic Acid ◽  
Human Skin ◽  
Lysophosphatidic Acid ◽  
Acid Synthesis ◽  
Human Skin Fibroblasts ◽  
Transcription Factor Regulation ◽  
Cyclic Phosphatidic Acid ◽  
Creb Transcription Factor

Age-related changes in cyclic phosphatidic acid-induced hyaluronic acid synthesis in human fibroblasts

Human Cell ◽  
2017 ◽  
Vol 31 (1) ◽  
pp. 72-77 ◽  
Author(s):  
Katsura Sano ◽  
Mari Gotoh ◽  
Kyoko Dodo ◽  
Noriaki Tajima ◽  
Yoshibumi Shimizu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Phosphatidic Acid ◽  
Human Fibroblasts ◽  
Acid Synthesis ◽  
Age Related ◽  
Cyclic Phosphatidic Acid ◽  
Age Related Changes

2- O -Carba-oleoyl cyclic phosphatidic acid induces glial proliferation through the activation of lysophosphatidic acid receptor

2018 ◽  
Vol 1681 ◽  
pp. 44-51 ◽  
Author(s):  
Shingo Nakajima ◽  
Mari Gotoh ◽  
Keiko Fukasawa ◽  
Hiromu Murofushi ◽  
Kimiko Murakami-Murofushi
Keyword(s):  
Phosphatidic Acid ◽  
Lysophosphatidic Acid ◽  
Acid Receptor ◽  
Lysophosphatidic Acid Receptor ◽  
Glial Proliferation ◽  
Cyclic Phosphatidic Acid

Activation of bacterial ceramidase by anionic glycerophospholipids: possible involvement in ceramide hydrolysis on atopic skin by Pseudomonas ceramidase

2002 ◽  
Vol 362 (3) ◽  
pp. 619-626 ◽  
Author(s):  
Katsuhiro KITA ◽  
Noriyuki SUEYOSHI ◽  
Nozomu OKINO ◽  
Masanori INAGAKI ◽  
Hideharu ISHIDA ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Atopic Dermatitis ◽  
Phosphatidic Acid ◽  
Human Skin ◽  
Lysophosphatidic Acid ◽  
Atopic Skin ◽  
Hydrolysis Of ◽  
Lipid Components

We have reported previously that the ceramidase from Pseudomonas aeruginosa AN17 isolated from a patient with atopic dermatitis requires detergents for hydrolysis of ceramide (Cer) [Okino, Tani, Imayama and Ito (1998) J. Biol. Chem. 273, 14368–14373]. In the present study, we report that some glycerophospholipids strongly activated the hydrolysis of Cer by Pseudomonas ceramidase in the absence of detergents. Among the glycerophospholipids tested, cardiolipin was most effective in stimulating hydrolysis of Cer followed by phosphatidic acid, phosphatidylethanolamine and phosphatidylglycerol, whereas phosphatidylcholine, lysophosphatidic acid and diacylglycerol were less effective. Interestingly, Staphylococcus aureus-derived lipids, which contain cardiolipin and phosphatidylglycerol as major lipid components, also strongly enhanced the hydrolysis of normal Cer, as well as the human skin-specific ω-hydroxyacyl Cer, by the enzyme in the absence of detergents. It was confirmed that several strains of P. aeruginosa, including AN17, secrete a significant amount of staphylolytic proteases to lyse S. aureus cells, resulting in the release of cardiolipin and phosphatidylglycerol. Since both P. aeruginosa and S. aureus are suspected of being present in microflora of atopic skin, we speculate that S. aureus-derived glycerophospholipids stimulate the hydrolysis of Cer in atopic skin by bacterial ceramidase.

Extracellular depolymerization of hyaluronic acid in cultured human skin fibroblasts

1990 ◽  
Vol 172 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Toshiya Nakamura ◽  
Keiichi Takagaki ◽  
Kohmei Kubo ◽  
Akiko Morikawa ◽  
Shinri Tamura ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Human Skin ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts

scholarly journals Protective influence of hyaluronic acid on focal adhesion kinase activity in human skin fibroblasts exposed to ethanol

2017 ◽  
Vol Volume11 ◽  
pp. 669-676 ◽  
Author(s):  
Magdalena Donejko ◽  
Edyta Rysiak ◽  
Elżbieta Galicka ◽  
Robert Terlikowski ◽  
Edyta Głażewska ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Focal Adhesion Kinase ◽  
Human Skin ◽  
Focal Adhesion ◽  
Kinase Activity ◽  
Skin Fibroblasts ◽  
Human Skin Fibroblasts ◽  
Focal Adhesion Kinase Activity
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