scholarly journals Inhibition of the prostaglandin EP2 receptor prevents long-term cognitive impairment in a model of systemic inflammation

2020 ◽  
Vol 8 ◽  
pp. 100132
Author(s):  
Chunxiang Jiang ◽  
Aysegul Caskurlu ◽  
Thota Ganesh ◽  
Ray Dingledine
Keyword(s):  
Cognitive Impairment ◽  
Systemic Inflammation ◽  
Ep2 Receptor

scholarly journals Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Joana Costa d’Avila ◽  
Luciana Domett Siqueira ◽  
Aurélien Mazeraud ◽  
Estefania Pereira Azevedo ◽  
Debora Foguel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cognitive Impairment ◽  
Mouse Model ◽  
Systemic Inflammation ◽  
Age Related ◽  
And Oxidative Stress

scholarly journals Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the Hippocampus

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Efrat Shavit-Stein ◽  
Amir Dori ◽  
Marina Ben Shimon ◽  
Shany Guly Gofrit ◽  
Nicola Maggio
Keyword(s):  
Cognitive Impairment ◽  
Systemic Inflammation ◽  
Long Term Potentiation ◽  
Short Exposure ◽  
Short Term ◽  
Cholinergic Dysfunction ◽  
Term Potentiation ◽  
Hippocampal Synapses ◽  
The Brain

The cholinergic system plays a fundamental role in learning and memory. Pharmacological activation of the muscarinic receptor M1R potentiates NMDA receptor activity and induces short-term potentiation at the synapses called muscarinic LTP, mLTP. Dysfunction of cholinergic transmission has been detected in the settings of cognitive impairment and dementia. Systemic inflammation as well as neuroinflammation has been shown to profoundly alter synaptic transmission and LTP. Indeed, intervention which is aimed at reducing neuroinflammatory changes in the brain has been associated with an improvement in cognitive functions. While cognitive impairment caused either by cholinergic dysfunction and/or by systemic inflammation suggests a possible connection between the two, so far whether systemic inflammation affects mLTP has not been extensively studied. In the present work, we explored whether an acute versus persistent systemic inflammation induced by LPS injections would differently affect the ability of hippocampal synapses to undergo mLTP. Interestingly, while a short exposure to LPS resulted in a transient deficit in mLTP expression, a longer exposure persistently impaired mLTP. We believe that these findings may be involved in cognitive dysfunctions following sepsis and possibly neuroinflammatory processes.

scholarly journals Long-Term Systemic Inflammation and Cognitive Impairment in a Population-Based Cohort

2014 ◽  
Vol 62 (9) ◽  
pp. 1683-1691 ◽  
Author(s):  
Margarete A. Wichmann ◽  
Karen J. Cruickshanks ◽  
Cynthia M. Carlsson ◽  
Rick Chappell ◽  
Mary E. Fischer ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Systemic Inflammation ◽  
Population Based

scholarly journals IMMUNOLOGICAL MARKERS OF LONG-TERM EFFECTS OF TREATMENT IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT

2019 ◽  
Vol 19 (1S) ◽  
pp. 84-86
Author(s):  
S A Krynskiy ◽  
I K Malashenkova ◽  
N A Hailov ◽  
D P Ogurtsov ◽  
E I Chekulaeva ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Systemic Inflammation ◽  
Long Term Effects ◽  
Immune Parameters ◽  
Effect Of Therapy ◽  
Risk Of Progression ◽  
Immunological Examination ◽  
Neurotrophic Therapy

The goal of this research was to study the clinical efficacy of course-based neurotrophic therapy in mild cognitive impairment (MCI) and the effect of therapy on immune parameters in patients, and to assess the prognostic value of the dynamics of immune parameters during the year after treatment. 20 patients with MCI receiving intravenous Cerebrolysin (20 infusions of 30 ml with increasing dose during the first four days) were examined. Neuropsychological and immunological examination was carried out immediately before the study, after 3 months., 6 months and after 1 year after the end of treatment. It was found that after therapy, patients had a long-term decrease in the severity of systemic inflammatory response, and that marked signs of systemic inflammation at the beginning of follow-up combined with a persistent decrease in the level of immunoglobulin G in dynamics were prognostic markers of MCI progression. In conclusion, it wass shown that neurotrophic therapy has a good clinical effect and has a favorable immunomodulatory effect in aMCI, and the relationship between the dynamics of humoral immunity and systemic inflammation and the risk of progression of cognitive impairment in patients within 1 year after therapy was established.

Physical activity and cognitive function in older persons

2016 ◽  
Vol 64 (2) ◽  
Keyword(s):  
Physical Activity ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Executive Functions ◽  
Cognitive Aging ◽  
Clinical Studies ◽  
Older Persons ◽  
Positive Effects ◽  
Critical Challenge

Strategies to improve cognitive aging are highly needed. Among those, promotion of exercise and physical activity appears as one of the most attractive and beneficial intervention. Indeed, results from basic and clinical studies suggest that exercise and physical activity have positive effects on cognition in older persons without cognitive impairment, as well as in those with dementia. Despite inconsistent results, aerobic exercise appears to have the strongest potential to enhance cognition. However, even limited periods of walking (45 minutes, three times a week, over a 6-month period) have also been shown to enhance cognition, particularly executive functions. Changing long-term lifestyle habits in these older persons remains a critical challenge and attractive programs susceptible to gain adherence are needed to succeed in achieving improved cognitive aging.

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