Post-acquisition hippocampal NMDA receptor blockade sustains retention of spatial reference memory in Morris water maze

2014 ◽  
Vol 259 ◽  
pp. 261-267 ◽  
Author(s):  
Keisuke Shinohara ◽  
Toshimichi Hata
Keyword(s):  
Nmda Receptor ◽  
Morris Water Maze ◽  
Water Maze ◽  
Reference Memory ◽  
Receptor Blockade ◽  
Spatial Reference ◽  
Nmda Receptor Blockade ◽  
Spatial Reference Memory

scholarly journals Reducing expression of GluN10XX subunit splice variants of the NMDA receptor interferes with spatial reference memory

2012 ◽  
Vol 230 (2) ◽  
pp. 317-324 ◽  
Author(s):  
Siba R. Das ◽  
Ross Jensen ◽  
Rian Kelsay ◽  
Michelle Shumaker ◽  
Rachele Bochart ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Splice Variants ◽  
Reference Memory ◽  
Spatial Reference ◽  
Spatial Reference Memory

scholarly journals Cognitive-Enhancing Effects of Polygalasaponin Hydrolysate in Aβ25–35-Induced Amnesic Mice

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Shu ping Xu ◽  
Yan yan Yang ◽  
Dan Xue ◽  
Jin xiu Liu ◽  
Xin min Liu ◽  
...  
Keyword(s):  
Water Maze ◽  
Antioxidant Properties ◽  
Reference Memory ◽  
Dark Chamber ◽  
Spatial Reference ◽  
Error Frequency ◽  
Polygala Tenuifolia ◽  
Spatial Reference Memory ◽  
Avoidance Tests ◽  
Retention Trial

Polygalasaponins are the major active constituents ofPolygala tenuifoliaexhibiting antiamnesic activity, but their applications are limited due to their toxicities. Evidence showed that the toxicities can be attenuated by hydrolysis. Herein, effects of a hydrolysate of polygalasaponins (HPS) on cognitive impairment induced by Aβ25−35were assessed by Morris water maze and step-through passive avoidance tests. The impaired spatial reference memory was improved by HPS (50 and 100 mg/kg). In the acquisition trial of step-through test, HPS (50 and 100 mg/kg) increased the latency into the dark chamber and decreased the error frequency significantly (). However, no significant change was observed during the retention trial. Additionally, HPS increased the corresponding SOD activities (62.34%, 22.09%) and decreased MDA levels (28.21%, 32.35%) in both cortex and hippocampus as compared to model animals. These results show that HPS may be a useful treatment against amnesia probably via its antioxidant properties.

Maslinic acid ameliorates NMDA receptor blockade-induced schizophrenia-like behaviors in mice

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381 ◽  
Author(s):  
H Kim ◽  
SJ Jeon ◽  
E Kim ◽  
J Zhang ◽  
Y Gwon ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Receptor Blockade ◽  
Maslinic Acid ◽  
Nmda Receptor Blockade

NMDA receptor blockade by memantine increases hormonal counterregulation during hypoglycaemia

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
I Pais ◽  
C Hubold ◽  
M Hallschmid ◽  
KM Oltmanns ◽  
B Schultes ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Receptor Blockade ◽  
Nmda Receptor Blockade

Spatial reference memory in GluR-A-deficient mice using a novel hippocampal-dependent paddling pool escape task

Hippocampus ◽  
2004 ◽  
Vol 14 (2) ◽  
pp. 216-223 ◽  
Author(s):  
W.B. Schmitt ◽  
R.M.J. Deacon ◽  
D. Reisel ◽  
R. Sprengel ◽  
P.H. Seeburg ◽  
...  
Keyword(s):  
Reference Memory ◽  
Spatial Reference ◽  
Spatial Reference Memory ◽  
Deficient Mice

Hippocampal NMDA receptor blockade impairs CREB phosphorylation in amygdala after contextual fear conditioning

Hippocampus ◽  
2013 ◽  
Vol 23 (7) ◽  
pp. 545-551 ◽  
Author(s):  
Cesar Augusto de Oliveira Coelho ◽  
Tatiana Lima Ferreira ◽  
Juliana Carlota Kramer Soares ◽  
Maria Gabriela Menezes Oliveira
Keyword(s):  
Nmda Receptor ◽  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Receptor Blockade ◽  
Creb Phosphorylation ◽  
Contextual Fear ◽  
Nmda Receptor Blockade
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