Insight into why pyrrolidinyl peptide nucleic acid binding to DNA is more stable than the DNA·DNA duplex

2008 ◽  
Vol 372 (4) ◽  
pp. 765-771 ◽  
Author(s):  
Khatcharin Siriwong ◽  
Parawan Chuichay ◽  
Suwipa Saen-oon ◽  
Chaturong Suparpprom ◽  
Tirayut Vilaivan ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Nucleic Acid Binding ◽  
Insight Into

Quinoxaline Antibiotics Enhance Peptide Nucleic Acid Binding to Double-Stranded DNA†

Biochemistry ◽  
2000 ◽  
Vol 39 (31) ◽  
pp. 9502-9507 ◽  
Author(s):  
Niels Erik Møllegaard ◽  
Christian Bailly ◽  
Michael J. Waring ◽  
Peter E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Nucleic Acid Binding ◽  
Double Stranded Dna

scholarly journals Site-specific cleavage of mutant ABL mRNA by DNAzyme is facilitated by peptide nucleic acid binding to RNA substrate

FEBS Letters ◽  
2012 ◽  
Vol 586 (21) ◽  
pp. 3865-3869 ◽  
Author(s):  
Ji Eun Kim ◽  
Soojin Yoon ◽  
Hyejung Mok ◽  
Woong Jung ◽  
Dong-Eun Kim
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Nucleic Acid Binding ◽  
Site Specific

scholarly journals Mtr4 RNA helicase structures and interactions

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Keith J. Olsen ◽  
Sean J. Johnson
Keyword(s):  
Nucleic Acid ◽  
Dynamic Process ◽  
Rna Helicase ◽  
Degradation Pathways ◽  
Nucleic Acid Binding ◽  
Rna Surveillance ◽  
The Past ◽  
Binding Partners ◽  
Rna Exosome ◽  
Insight Into

Abstract Mtr4 is a Ski2-like RNA helicase that plays a central role in RNA surveillance and degradation pathways as an activator of the RNA exosome. Multiple crystallographic and cryo-EM studies over the past 10 years have revealed important insight into the Mtr4 structure and interactions with protein and nucleic acid binding partners. These structures place Mtr4 at the center of a dynamic process that recruits RNA substrates and presents them to the exosome. In this review, we summarize the available Mtr4 structures and highlight gaps in our current understanding.

Hybrid nanotechnology and peptide nucleic acid could improve the effectiveness of gene therapy by increasing its cell permeability

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Carbon Nanotubes ◽  
Gene Therapy ◽  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Intracellular Delivery ◽  
Cell Permeability ◽  
Full Potential ◽  
Hybrid Nanotechnology ◽  
Insight Into ◽  
The Way

The utilization of nanoparticles and carbon nanotubes in PNA-based technologies has opened the way for the application of nanotechnology in oligonucleotide compilation. It is possible that further study may offer insight into how to improve the effectiveness of oligonucleotides by increasing their cell permeability. Because PNA accumulates within the cell when it is transported by a lipid-based carrier, it has insufficient cytosolic dispersion, which greatly limits its medicinal potential. This finding suggests that nanoparticles and nanostructures that are similar in appearance to carbon nanotubes can be employed to efficiently disseminate PNA. Innovative ways of intracellular delivery of PNA, such as the use of viruses and nutrients, will require significant and in-depth exploration before they can reach their full potential.

scholarly journals Kinetics and mechanism of polyamide ("peptide") nucleic acid binding to duplex DNA.

1995 ◽  
Vol 92 (7) ◽  
pp. 2637-2641 ◽  
Author(s):  
V. V. Demidov ◽  
M. V. Yavnilovich ◽  
B. P. Belotserkovskii ◽  
M. D. Frank-Kamenetskii ◽  
P. E. Nielsen
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Kinetics And Mechanism ◽  
Duplex Dna ◽  
Nucleic Acid Binding
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