Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice

2011 ◽  
Vol 406 (1) ◽  
pp. 134-140 ◽  
Author(s):  
Izumi Onozuka ◽  
Sei Kakinuma ◽  
Akihide Kamiya ◽  
Masato Miyoshi ◽  
Naoya Sakamoto ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Deficient Mice

Myeloperoxidase deficiency ameliorates progression of chronic kidney disease in mice

2014 ◽  
Vol 307 (4) ◽  
pp. F407-F417 ◽  
Author(s):  
Alexander Lehners ◽  
Sascha Lange ◽  
Gianina Niemann ◽  
Alva Rosendahl ◽  
Catherine Meyer-Schwesinger ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Matrix Metalloproteinase ◽  
Collagen Type ◽  
Matrix Metalloproteinase 2 ◽  
Marker Genes ◽  
Wild Type ◽  
Renal Ablation ◽  
The Impact ◽  
Deficient Mice

Myeloperoxidase (MPO) is an enzyme expressed in neutrophils and monocytes/macrophages. Beside its well-defined role in innate immune defence, it may also be responsible for tissue damage. To identify the role of MPO in the progression of chronic kidney disease (CKD), we investigated CKD in a model of renal ablation in MPO knockout and wild-type mice. CKD was induced by 5/6 nephrectomy. Mice were followed for 10 wk to evaluate the impact of MPO deficiency on renal morbidity. Renal ablation induced CKD in wild-type mice with increased plasma levels of MPO compared with controls. No difference was found between MPO-deficient and wild-type mice regarding albuminuria 1 wk after renal ablation, indicating similar acute responses to renal ablation. Over the next 10 wk, however, MPO-deficient mice developed significantly less albuminuria and glomerular injury than wild-type mice. This was accompanied by a significantly lower renal mRNA expression of the fibrosis marker genes plasminogen activator inhibitor-I, collagen type III, and collagen type IV as well as matrix metalloproteinase-2 and matrix metalloproteinase-9. MPO-deficient mice also developed less renal inflammation after renal ablation, as indicated by a lower infiltration of CD3-positive T cells and F4/80-positive monocytes/macrophages compared with wild-type mice. In vitro chemotaxis of monocyte/macrophages isolated from MPO-deficient mice was impaired compared with wild-type mice. No significant differences were observed for mortality and blood pressure after renal ablation. In conclusion, these results demonstrate that MPO deficiency ameliorates renal injury in the renal ablation model of CKD in mice.

scholarly journals Loss of Matrix Metalloproteinase-2 Amplifies Murine Toxin-Induced Liver Fibrosis by Upregulating Collagen I Expression

2010 ◽  
Vol 56 (2) ◽  
pp. 406-416 ◽  
Author(s):  
Brian D. Radbill ◽  
Ritu Gupta ◽  
Maria Celeste M. Ramirez ◽  
Analisa DiFeo ◽  
John A. Martignetti ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Matrix Metalloproteinase ◽  
Collagen I ◽  
Matrix Metalloproteinase 2

Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis

2004 ◽  
Vol 24 (5) ◽  
pp. 492-501 ◽  
Author(s):  
Xiaoying Zhou ◽  
Christopher J. Hovell ◽  
Susannah Pawley ◽  
Matthew I. Hutchings ◽  
Michael J. P. Arthur ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Experimental Liver

Reduced Choroidal Neovascular Membrane Formation in Matrix Metalloproteinase-2–Deficient Mice

2003 ◽  
Vol 44 (1) ◽  
pp. 403 ◽  
Author(s):  
Lennart Berglin ◽  
Sylvia Sarman ◽  
Ingeborg van der Ploeg ◽  
Bjo¨rn Steen ◽  
Yue Ming ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 2 ◽  
Choroidal Neovascular Membrane ◽  
Membrane Formation ◽  
Deficient Mice

scholarly journals Unaltered Secretion of β-Amyloid Precursor Protein in Gelatinase A (Matrix Metalloproteinase 2)-deficient Mice

1997 ◽  
Vol 272 (36) ◽  
pp. 22389-22392 ◽  
Author(s):  
Takeshi Itoh ◽  
Toshio Ikeda ◽  
Hiroshi Gomi ◽  
Shinobu Nakao ◽  
Toshiharu Suzuki ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Matrix Metalloproteinase 2 ◽  
Gelatinase A ◽  
Β Amyloid ◽  
Deficient Mice
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