miR-7-5p acts as a tumor suppressor in bladder cancer by regulating the hedgehog pathway factor Gli3

2018 ◽  
Vol 503 (3) ◽  
pp. 2101-2107 ◽  
Author(s):  
Jun Li ◽  
Mingxing Qiu ◽  
Yu An ◽  
Jianlin Huang ◽  
Chunyu Gong
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Hedgehog Pathway

scholarly journals Propofol Inhibits the Proliferation, Migration, and Stem-like Properties of Bladder Cancer Mainly by Suppressing the Hedgehog Pathway

2021 ◽  
Vol 30 ◽  
pp. 096368972098511
Author(s):  
Gang Li ◽  
Xu Zhang ◽  
Xiangyang Guo ◽  
Yi Li ◽  
Chong Li
Keyword(s):  
Stem Cells ◽  
Bladder Cancer ◽  
Bladder Tumor ◽  
Therapeutic Agent ◽  
Tumor Formation ◽  
The Self ◽  
Hedgehog Pathway ◽  
Self Renewal ◽  
Intravenous Anesthetic ◽  
Novel Therapeutic

Bladder cancer is one of the most common malignancies. The existence of bladder cancer stem cells (BCSCs) has been suggested to underlie bladder tumor initiation and recurrence. Propofol is a commonly used intravenous anesthetic. Here, we find that propofol can dramatically block the activation of Hedgehog pathway in BCSCs. The propofol strongly repressed the growth of cancer cells. Attenuated proliferation and enhanced apoptosis of tumor cells were observed upon propofol stimulation. Furthermore, propofol reduced the self-renewal ability of BCSCs as well as the tumor formation. In conclusion, propofol is potentially used as a novel therapeutic agent for bladder cancer by targeting self-renewal through inhibiting Hedgehog pathway.

Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer

1999 ◽  
Vol 26 (2) ◽  
pp. 171-175 ◽  
Author(s):  
Hiroyuki Nishiyama ◽  
Takeshi Takahashi ◽  
Yoshiyuki Kakehi ◽  
Tomonori Habuchi ◽  
Margaret A. Knowles
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Homozygous Deletion ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Candidate Tumor Suppressor

scholarly journals MicroRNA-490-5p is a novel tumor suppressor targeting c-FOS in human bladder cancer

2015 ◽  
Vol 3 ◽  
pp. 561-569 ◽  
Author(s):  
Gongbin Lan ◽  
Luoyan Yang ◽  
Xubiao Xie ◽  
Longkai Peng ◽  
Yi Wang
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Human Bladder Cancer ◽  
Human Bladder

scholarly journals A novel model to identify interaction partners of the PTEN tumor suppressor gene in human bladder cancer

2007 ◽  
Vol 352 (2) ◽  
pp. 549-555 ◽  
Author(s):  
Mikael Herlevsen ◽  
Gary Oxford ◽  
Celeste Ptak ◽  
Jeffrey Shabanowitz ◽  
Donald F. Hunt ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Interaction Partners ◽  
Novel Model

scholarly journals MP65-10 THE TUMOR SUPPRESSOR MICRORNA-223 TARGETS WDR62 DIRECTLY IN BLADDER CANCER

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Satoshi Sugita ◽  
Hirofumi Yoshino ◽  
Kazutaka Miyamoto ◽  
Masaya Yonemori ◽  
Takashi Sakaguchi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor

scholarly journals Four tumor suppressor loci on chromosome 9q in bladder cancer: evidence for two novel candidate regions at 9q22.3 and 9q31

Oncogene ◽  
1999 ◽  
Vol 18 (1) ◽  
pp. 157-163 ◽  
Author(s):  
Maryse Simoneau ◽  
Tahar O Aboulkassim ◽  
Hélène LaRue ◽  
François Rousseau ◽  
Yves Fradet
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Chromosome 9Q ◽  
Candidate Regions
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