scholarly journals Crystal structure of the 65-kilodalton amino-terminal fragment of DNA topoisomerase I from the gram-positive model organism Streptococcus mutans

2019 ◽  
Vol 516 (2) ◽  
pp. 333-338 ◽  
Author(s):  
Jesse A. Jones ◽  
Kirk E. Hevener
Keyword(s):  
Crystal Structure ◽  
Streptococcus Mutans ◽  
Topoisomerase I ◽  
Model Organism ◽  
Dna Topoisomerase I ◽  
Gram Positive ◽  
Dna Topoisomerase ◽  
Amino Terminal ◽  
Terminal Fragment ◽  
Amino Terminal Fragment

Synthesis, crystal structure, DNA interaction and in vitro anticancer activity of a Cu(ii) complex of purpurin: dual poison for human DNA topoisomerase I and II

RSC Advances ◽  
2014 ◽  
Vol 4 (103) ◽  
pp. 59344-59357 ◽  
Author(s):  
Piyal Das ◽  
Chetan Kumar Jain ◽  
Sanjoy K. Dey ◽  
Rajat Saha ◽  
Abhishek Dutta Chowdhury ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Topoisomerase I ◽  
Dna Interaction ◽  
Dna Topoisomerase I ◽  
Oxygen Species ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Anti Tumor Activity ◽  
Human Dna Topoisomerase I

Although generation of reactive oxygen species (ROS) by anthracycline anticancer drugs is essential for anti-tumor activity, they make these drugs cardiotoxic.

Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I

Nature ◽  
1994 ◽  
Vol 367 (6459) ◽  
pp. 138-146 ◽  
Author(s):  
Christopher D. Lima ◽  
James C. Wang ◽  
Alfonso Mondragón
Keyword(s):  
Topoisomerase I ◽  
Three Dimensional ◽  
Dimensional Structure ◽  
Dna Topoisomerase I ◽  
Dna Topoisomerase ◽  
Three Dimensional Structure ◽  
E Coli ◽  
Terminal Fragment
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