Drosophila ZnT1 is essential in the intestine for dietary zinc absorption

Unlike iron, zinc absorption is influenced by dietary zinc intake, not zinc status. As dietary zinc increases, the total amount of absorbed zinc increases while the percent absorbed declines. The gastrointestinal tract maintains whole-body zinc homeostasis by adjusting endogenous zinc losses to the amount absorbed. At intakes below about 9 mg/day, zinc absorption occurs primarily by a saturable (carrier) process involving ZIP4, ZnT1, and other transporters. There is no evidence that past zinc intakes, or status, influences zinc absorption. Instead, current zinc intake is the chief determinant of zinc absorption. Supplemental zinc taken with water in the post-absorptive state initially is absorbed more efficiently than food zinc, but absorption efficiency declines within 24 hours presumably due to down-regulation of the zinc transporters. More research is needed to understand the effect of physiological state on zinc absorption.

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Dietary zinc absorption is mediated by ZnT1 in Drosophila melanogaster

The FASEB Journal ◽

10.1096/fj.08-126649 ◽

2009 ◽

Vol 23 (8) ◽

pp. 2650-2661 ◽

Cited By ~ 52

Author(s):

Xiaoxi Wang ◽

Yuantai Wu ◽

Bing Zhou

Keyword(s):

Drosophila Melanogaster ◽

Zinc Absorption ◽

Dietary Zinc

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Influence of dietary zinc concentration and supplemental zinc source on nutrient digestibility, zinc absorption, and retention in sheep1

Journal of Animal Science ◽

10.1093/jas/sky384 ◽

2018 ◽

Vol 96 (12) ◽

pp. 5336-5344 ◽

Cited By ~ 6

Author(s):

Katherine R VanValin ◽

Olivia N Genther-Schroeder ◽

Remy N Carmichael ◽

Christopher P Blank ◽

Erin L Deters ◽

...

Keyword(s):

Zinc Concentration ◽

Nutrient Digestibility ◽

Zinc Absorption ◽

Dietary Zinc ◽

Zinc Source ◽

Supplemental Zinc

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Current dietary zinc intake has a greater effect on fractional zinc absorption than does longer term zinc consumption in healthy adult men

American Journal of Clinical Nutrition ◽

10.1093/ajcn/87.5.1224 ◽

2008 ◽

Vol 87 (5) ◽

pp. 1224-1229 ◽

Cited By ~ 33

Author(s):

Carolyn S Chung ◽

Jodi Stookey ◽

Doris Dare ◽

Ross Welch ◽

Tuan Q Nguyen ◽

...

Keyword(s):

Healthy Adult ◽

Zinc Absorption ◽

Dietary Zinc ◽

Zinc Intake ◽

Adult Men

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Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation

BMC Biology ◽

10.1186/1741-7007-11-101 ◽

2013 ◽

Vol 11 (1) ◽

pp. 101 ◽

Cited By ~ 32

Author(s):

Qiuhong Qin ◽

Xiaoxi Wang ◽

Bing Zhou

Keyword(s):

Zinc Transporters ◽

Zinc Absorption ◽

Dietary Zinc ◽

Functional Studies

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Influence of Dairy Products on Bioavailability of Zinc from Other Food Products: A Review of Complementarity at a Meal Level

Nutrients ◽

10.3390/nu13124253 ◽

2021 ◽

Vol 13 (12) ◽

pp. 4253

Author(s):

Blerina Shkembi ◽

Thom Huppertz

Keyword(s):

Dairy Products ◽

Food Products ◽

Zinc Absorption ◽

Dietary Zinc ◽

Zinc Intake ◽

Beneficial Effects ◽

Dairy Consumption ◽

Dietary Strategy ◽

Zinc Sources

In this paper, we reviewed the role of dairy products in dietary zinc absorption. Dairy products can have a reasonable contribution for dietary zinc intake in Western diets, where dairy consumption is high. However, the co-ingestion of dairy products can also improve zinc absorption from other food products. Such improvements have been observed when dairy products (e.g., milk or yoghurt) were ingested together with food such as rice, tortillas or bread products, all of which are considered to be high-phytate foods with low inherent zinc absorption. For foods low in phytate, the co-ingestion of dairy products did not improve zinc absorption. Improved zinc absorption of zinc from high-phytate foods following co-ingestion with dairy products may be related to the beneficial effects of the citrate and phosphopeptides present in dairy products. Considering that the main dietary zinc sources in areas in the world where zinc deficiency is most prevalent are typically high in phytate, the inclusion of dairy products in meals may be a viable dietary strategy to improve zinc absorption.

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