Does Zinc Absorption Reflect Zinc Status?

2010 ◽  
Vol 80 (45) ◽  
pp. 300-306 ◽  
Author(s):  
Janet C. King
Keyword(s):  
Physiological State ◽  
Absorption Efficiency ◽  
Zinc Homeostasis ◽  
Zinc Transporters ◽  
Whole Body ◽  
Zinc Absorption ◽  
Zinc Status ◽  
Dietary Zinc ◽  
Zinc Intake ◽  
Supplemental Zinc

Unlike iron, zinc absorption is influenced by dietary zinc intake, not zinc status. As dietary zinc increases, the total amount of absorbed zinc increases while the percent absorbed declines. The gastrointestinal tract maintains whole-body zinc homeostasis by adjusting endogenous zinc losses to the amount absorbed. At intakes below about 9 mg/day, zinc absorption occurs primarily by a saturable (carrier) process involving ZIP4, ZnT1, and other transporters. There is no evidence that past zinc intakes, or status, influences zinc absorption. Instead, current zinc intake is the chief determinant of zinc absorption. Supplemental zinc taken with water in the post-absorptive state initially is absorbed more efficiently than food zinc, but absorption efficiency declines within 24 hours presumably due to down-regulation of the zinc transporters. More research is needed to understand the effect of physiological state on zinc absorption.

The role of zinc status in altered cardiac adenylate cyclase activity in diabetic rats

1988 ◽  
Vol 119 (2) ◽  
pp. 174-180 ◽  
Author(s):  
Arshag D. Mooradian ◽  
John E. Morley ◽  
Philip J. Scarpace
Keyword(s):  
Adenylate Cyclase ◽  
Adrenergic Receptor ◽  
Diabetic Rats ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Zinc Status ◽  
Dietary Zinc ◽  
Zinc Intake ◽  
Diabetic State ◽  
High Zinc

Abstract. Zinc deficiency and altered myocardial adenylate cyclase activity commonly occur in diabetes. To determine whether the zinc intake of the animal can account for the altered β-adrenergic receptor activity in the diabetic heart, we determined the β-adrenergic receptor number and isoproterenol-, NaF- and forskolin-stimulated adenylate cyclase activity in diabetic and control rats maintained on low, normal and high zinc diets for 3 weeks. Scatchard analysis of [125I]iodocyanopindolol binding to control heart membrane preparations revealed a binding capacity of 17.3 ± 1.3 fmol/mg protein with a Kd of 35 ± 1.0 pmol/l. Neither the diabetic state nor the zinc status altered these binding parameters. The isoproterenol-stimulated adenylate cyclase acticity was significantly lower in diabetic rats on low zinc diets compared with controls. The NaF- (65.1 ± 5.4 vs 60.8 ± 6.4 pmol cAMP·mg protein−1·min−1) and forskolin-stimulated adenylate cyclase activities (161 ± 9.3 vs 154 ± 21.2 pmol cAMP·mg protein−1· min−1) were not significantly altered in diabetic rats. Low dietary zinc intake compared with high zinc diet significantly increased NaF- and forskolin-stimulated adenylate cyclase activity both in diabetic rats and controls. The effect of dietary zinc content on isoproterenol-stimulated adenylate cyclase was significant in control rats only. Thus zinc intake appears to be an important determinant of cardiac adenylate cyclase activity level. Additional factors peculiar to the diabetic state are involved in the modulation of β-adrenergic responsiveness of the diabetic heart.

Zinc intake and status in Austria in the light of different reference values

2017 ◽  
Vol 87 (3-4) ◽  
pp. 169-178 ◽  
Author(s):  
Ibrahim Elmadfa ◽  
Alexa L. Meyer ◽  
Timo Kuen ◽  
Karin Wagner ◽  
Verena Hasenegger
Keyword(s):  
Reference Values ◽  
Daily Intake ◽  
The Elderly ◽  
Institute Of Medicine ◽  
Zinc Status ◽  
Dietary Zinc ◽  
Zinc Intake ◽  
Antioxidative Status ◽  
Nationally Representative ◽  
Using Data

Abstract. Zinc has been identified as a critical micronutrient also in high-income countries. There is still some uncertainty about the evaluation of zinc sufficiency due to divergent daily intake reference values. We wanted to exemplify this issue using data from the Austrian Study on Nutritional Status 2012. Plasma zinc concentrations were measured in a nationally representative sample of 872 persons aged 6–80 years (55.5 % female). Dietary zinc intake was estimated from two 24h dietary recalls. Additionally, parameters of the antioxidative status (plasma malondialdehyde (MDA), total antioxidative capacity) and activities of alkaline phosphatase (AP), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px)) were determined. Zinc status was marginal in schoolchildren (40 % of boys and 22 % of girls) and in elderly (28 % of men and 33 % of women). Dietary zinc intake was also unsatisfactory in these groups with 38 % of boys and 32 % of girls and 64.5 % of older men below the nationally recommended intake levels. However, the adequacy of zinc intake varied with different reference values. Adults were more likely to meet the D-A-CH reference values and those from the European Food Safety Authority than the recommendations of the International Zinc Nutrition Consultative Group (IZiNCG) and the Institute of Medicine, whereas children met the IZiNCG values best. Zinc status correlated weakly with AP activity (r = –0.298, p < 0.001) and some antioxidant status markers (CAT, MDA, GSH-PX, SOD), especially in the elderly (MDA: r = –0.527, p < 0.001, and SOD: r = –0.466, p = 0.002). Our results suggest a suboptimal zinc supply in Austria particularly among schoolchildren and older adults.

scholarly journals Influence of dietary zinc concentration and supplemental zinc source on nutrient digestibility, zinc absorption, and retention in sheep1

2018 ◽  
Vol 96 (12) ◽  
pp. 5336-5344 ◽  
Author(s):  
Katherine R VanValin ◽  
Olivia N Genther-Schroeder ◽  
Remy N Carmichael ◽  
Christopher P Blank ◽  
Erin L Deters ◽  
...  
Keyword(s):  
Zinc Concentration ◽  
Nutrient Digestibility ◽  
Zinc Absorption ◽  
Dietary Zinc ◽  
Zinc Source ◽  
Supplemental Zinc

scholarly journals Current dietary zinc intake has a greater effect on fractional zinc absorption than does longer term zinc consumption in healthy adult men

2008 ◽  
Vol 87 (5) ◽  
pp. 1224-1229 ◽  
Author(s):  
Carolyn S Chung ◽  
Jodi Stookey ◽  
Doris Dare ◽  
Ross Welch ◽  
Tuan Q Nguyen ◽  
...  
Keyword(s):  
Healthy Adult ◽  
Zinc Absorption ◽  
Dietary Zinc ◽  
Zinc Intake ◽  
Adult Men

Zinc Transporters in the Mouse Placenta Show a Coordinated Regulatory Response to Changes in Dietary Zinc Intake

Placenta ◽  
2007 ◽  
Vol 28 (5-6) ◽  
pp. 437-444 ◽  
Author(s):  
R.M. Helston ◽  
S.R. Phillips ◽  
J.A. McKay ◽  
K.A. Jackson ◽  
J.C. Mathers ◽  
...  
Keyword(s):  
Zinc Transporters ◽  
Dietary Zinc ◽  
Zinc Intake ◽  
Regulatory Response ◽  
Mouse Placenta

scholarly journals Curcumin Reduces Hepatic and White Adipose Tissue Inflammation and Expression of Specific Zinc Transporters in Diet-Induced Obese Mice

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 325-325
Author(s):  
Tariful Islam ◽  
Geetika Katasani ◽  
Iurii Koboziev ◽  
Kembra Albracht-Schulte ◽  
Shane Scoggin ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
White Adipose Tissue ◽  
Inflammatory Markers ◽  
Zinc Homeostasis ◽  
Metabolic Effects ◽  
Zinc Transporters ◽  
Whole Body ◽  
Mrna Levels ◽  
Alcoholic Fatty Liver ◽  
Anti Inflammatory

Abstract Objectives Obesity is a complex metabolic disease, that is often associated with non-alcoholic fatty liver disease (NAFLD). Inflammation is a common feature of both diseases. Curcumin, a traditionally used spice in Asia, exerts anti-inflammatory effects in liver and white adipose tissue (WAT) of diet-induced obese (DIO) mice. However, mechanisms involved in these beneficial effects remain obscure. Zinc is an important micronutrient involved in inflammatory responses. Whole-body zinc homeostasis plays a critical role in decreasing tissue specific inflammation. Zinc homeostasis is maintained mainly by zinc transporters known as ZnT (zinc transporters) and Zip (Zrt and Irt-like proteins) family. We propose that zinc transporters may contribute to curcumin's protective metabolic effects. Thus, the objective of this research was to determine curcumin's effects on inflammatory markers and zinc transporters in liver and WAT from DIO mice. Methods Male B6 mice were fed a HFD (45% kcal fat) or HFD supplemented with 0.4% (w/w) curcumin (HFC) for fourteen weeks. Serum triglycerides (TG) and free fatty acid (FFA) levels were measured. mRNA levels for inflammatory markers and zinc transporters were determined in WAT and liver by qRT-PCR. Results No significant changes were observed in body weight, serum TG and FFA levels with curcumin supplementation. However, gene expression of inflammatory markers, including Stat1, and Nf-KB subunit p65 were significantly reduced in liver and WAT from HFC group compared to HF (P &lt; 0.05). Furthermore, curcumin reduced hepatic zinc transporters Zip10, Zip14, ZnT10 but increased ZnT9 expression. In WAT, curcumin significantly reduced mRNA levels for Zip1, Zip14, ZnT1, and ZnT7 (P &lt; 0.05). Conclusions Our results indicate that zinc transporters may in part mediate the anti-inflammatory properties of curcumin, particularly Zip14, in WAT and liver of DIO mice. Future mechanistic studies are necessary to establish whether zinc transporters are required for curcumin's anti-inflammatory effects in obesity and associated NAFLD. Funding Sources AHA grant# 19AIREA34450279.

scholarly journals Influence of Dairy Products on Bioavailability of Zinc from Other Food Products: A Review of Complementarity at a Meal Level

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4253
Author(s):  
Blerina Shkembi ◽  
Thom Huppertz
Keyword(s):  
Dairy Products ◽  
Food Products ◽  
Zinc Absorption ◽  
Dietary Zinc ◽  
Zinc Intake ◽  
Beneficial Effects ◽  
Dairy Consumption ◽  
Dietary Strategy ◽  
Zinc Sources

In this paper, we reviewed the role of dairy products in dietary zinc absorption. Dairy products can have a reasonable contribution for dietary zinc intake in Western diets, where dairy consumption is high. However, the co-ingestion of dairy products can also improve zinc absorption from other food products. Such improvements have been observed when dairy products (e.g., milk or yoghurt) were ingested together with food such as rice, tortillas or bread products, all of which are considered to be high-phytate foods with low inherent zinc absorption. For foods low in phytate, the co-ingestion of dairy products did not improve zinc absorption. Improved zinc absorption of zinc from high-phytate foods following co-ingestion with dairy products may be related to the beneficial effects of the citrate and phosphopeptides present in dairy products. Considering that the main dietary zinc sources in areas in the world where zinc deficiency is most prevalent are typically high in phytate, the inclusion of dairy products in meals may be a viable dietary strategy to improve zinc absorption.

Biomarkers of Cardiovascular Risk in Obese Women and their Relationship with Zinc Status

2020 ◽  
Vol 16 (5) ◽  
pp. 734-742
Author(s):  
Juliana S. Severo ◽  
Jennifer B.S. Morais ◽  
Jessica B. Beserra ◽  
Kyria J. Clímaco Cruz ◽  
Ana R.S. de Oliveira ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Plasma Concentrations ◽  
Emission Spectrometry ◽  
Control Group ◽  
Zinc Status ◽  
Obese Women ◽  
Dietary Zinc ◽  
Zinc Intake ◽  
Waist Hip Ratio ◽  
Zinc Concentrations

Background: Excessive adipose tissue, in the case of common obesity, has been associated with an endocrine-metabolic alteration that contributes to a manifestation of dyslipidemia. To identify mechanisms which are involved in disorders of lipid metabolism, several nutrients have been studied, especially zinc, which act by regulating transcription factors that are important for synthesis and oxidation of lipids and act as an anti-inflammatory and antioxidant nutrient. Thus, the study makes an assessment of the zinc status and biomarkers of cardiovascular risk in obese women. Methods: A case-control study enrolling obese (body mass index (BMI) ≥35 kg/m²) and eutrophic (BMI 18.5-24.9 kg/m²) Brazilian women was conducted. Dietary zinc intake was assessed by the three-day food registry. Plasma, erythrocyte and urinary zinc concentrations were determined by inductively coupled plasma optical emission spectrometry. Cardiovascular risk was assessed by plasma concentrations of lipid fractions, and by anthropometric measures. Results: Both groups showed a dietary zinc intake above the recommendations, with no statistical difference between them (p >0.05). Mean plasma and erythrocyte zinc concentrations were significantly reduced in obese women, compared to the control group (p <0.05). Urinary zinc excretion was significantly higher in obese women (p <0.05), who also had a significantly higher cardiovascular risk when compared to the control group (p <0.05). An inverse correlation between dietary zinc intake and waist-hip ratio was found in obese women. Conclusion: Obese women presented zinc redistribution characterized by reduced concentrations in plasma and erythrocytes, dietary zinc intake above the recommended, and increased zinc excretion in the urine. This study shows dyshomeostasis of zinc in obesity, a possible role in adiposity control and, consequently, its protective role against cardiovascular risk, due to its influence on risk biomarkers, such as waist-hip ratio.

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