scholarly journals Carotenoids from mamey (Pouteria sapota) and carrot (Daucus carota) increase the oxidative stress resistance of Caenorhabditis elegans

2021 ◽  
Vol 26 ◽  
pp. 100989
Author(s):  
Marco Antonio González-Peña ◽  
José Daniel Lozada-Ramírez ◽  
Ana Eugenia Ortega-Regules
2019 ◽  
Vol 74 (8) ◽  
pp. 1180-1188 ◽  
Author(s):  
Thanet Sornda ◽  
Marina Ezcurra ◽  
Carina Kern ◽  
Evgeniy R Galimov ◽  
Catherine Au ◽  
...  

Abstract During aging, etiologies of senescence cause multiple pathologies, leading to morbidity and death. To understand aging requires identification of these etiologies. For example, Caenorhabditis elegans hermaphrodites consume their own intestinal biomass to support yolk production, which in later life drives intestinal atrophy and ectopic yolk deposition. Yolk proteins (YPs; vitellogenins) exist as three abundant species: YP170, derived from vit-1–vit-5; and YP115 and YP88, derived from vit-6. Here, we show that inhibiting YP170 synthesis leads to a reciprocal increase in YP115/YP88 levels and vice versa, an effect involving posttranscriptional mechanisms. Inhibiting YP170 production alone, despite increasing YP115/YP88 synthesis, reduces intestinal atrophy as much as inhibition of all YP synthesis, which increases life span. By contrast, inhibiting YP115/YP88 production alone accelerates intestinal atrophy and reduces life span, an effect that is dependent on increased YP170 production. Thus, despite copious abundance of both YP170 and YP115/YP88, only YP170 production is coupled to intestinal atrophy and shortened life span. In addition, increasing levels of YP115/YP88 but not of YP170 increases resistance to oxidative stress; thus, longevity resulting from reduced vitellogenin synthesis is not attributable to oxidative stress resistance.


PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e39515 ◽  
Author(s):  
Yeu-Ching Shi ◽  
Chan-Wei Yu ◽  
Vivian Hsiu-Chuan Liao ◽  
Tzu-Ming Pan

Author(s):  
Panthakarn Rangsinth ◽  
Anchalee Prasansuklab ◽  
Chatrawee Duangjan ◽  
Xiaojie Gu ◽  
Krai Meemon ◽  
...  

PLoS ONE ◽  
2009 ◽  
Vol 4 (1) ◽  
Author(s):  
Ingrid Masse ◽  
Laurent Molin ◽  
Laurent Mouchiroud ◽  
Philippe Vanhems ◽  
Francesca Palladino ◽  
...  

Redox Biology ◽  
2019 ◽  
Vol 21 ◽  
pp. 101111 ◽  
Author(s):  
Hongyuan Li ◽  
Liangping Su ◽  
Xin Su ◽  
Xin Liu ◽  
Dan Wang ◽  
...  

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e89933 ◽  
Author(s):  
Larissa de Freitas Bonomo ◽  
David Nunes Silva ◽  
Patrícia Ferreira Boasquivis ◽  
Franciny Aparecida Paiva ◽  
Joyce Ferreira da Costa Guerra ◽  
...  

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