Faculty Opinions recommendation of Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans.

2016 ◽  
Author(s):  
David Lombard
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Life Span ◽  
Stress Resistance ◽  
Oxidative Stress Resistance

scholarly journals Production of YP170 Vitellogenins Promotes Intestinal Senescence in Caenorhabditis elegans

2019 ◽  
Vol 74 (8) ◽  
pp. 1180-1188 ◽  
Author(s):  
Thanet Sornda ◽  
Marina Ezcurra ◽  
Carina Kern ◽  
Evgeniy R Galimov ◽  
Catherine Au ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Life Span ◽  
Stress Resistance ◽  
Later Life ◽  
Abundant Species ◽  
Yolk Proteins ◽  
Oxidative Stress Resistance ◽  
Vitellogenin Synthesis ◽  
Intestinal Atrophy

Abstract During aging, etiologies of senescence cause multiple pathologies, leading to morbidity and death. To understand aging requires identification of these etiologies. For example, Caenorhabditis elegans hermaphrodites consume their own intestinal biomass to support yolk production, which in later life drives intestinal atrophy and ectopic yolk deposition. Yolk proteins (YPs; vitellogenins) exist as three abundant species: YP170, derived from vit-1–vit-5; and YP115 and YP88, derived from vit-6. Here, we show that inhibiting YP170 synthesis leads to a reciprocal increase in YP115/YP88 levels and vice versa, an effect involving posttranscriptional mechanisms. Inhibiting YP170 production alone, despite increasing YP115/YP88 synthesis, reduces intestinal atrophy as much as inhibition of all YP synthesis, which increases life span. By contrast, inhibiting YP115/YP88 production alone accelerates intestinal atrophy and reduces life span, an effect that is dependent on increased YP170 production. Thus, despite copious abundance of both YP170 and YP115/YP88, only YP170 production is coupled to intestinal atrophy and shortened life span. In addition, increasing levels of YP115/YP88 but not of YP170 increases resistance to oxidative stress; thus, longevity resulting from reduced vitellogenin synthesis is not attributable to oxidative stress resistance.

scholarly journals Polygonum multiflorum Extract Exerts Antioxidative Effects and Increases Life Span and Stress Resistance in the Model Organism Caenorhabditis elegans via DAF-16 and SIR-2.1

Plants ◽  
2018 ◽  
Vol 7 (3) ◽  
pp. 60 ◽  
Author(s):  
Christina Saier ◽  
Christian Büchter ◽  
Karoline Koch ◽  
Wim Wätjen
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Life Span ◽  
Stress Resistance ◽  
Model Organism ◽  
Aging Effects ◽  
Polygonum Multiflorum ◽  
Oxidative Stress Resistance ◽  
Antioxidative Effects

Extracts of the Chinese plant Polygonum multiflorum (PME) are used for medicinal purposes as well as food supplement due to anti-aging effects. Despite of the common use of these food supplements, experimental data on physiological effects of PME and its underlying molecular mechanisms in vivo are limited. We used the model organism Caenorhabditis elegans to analyze anti-aging-effects of PME in vivo (life span, lipofuscin accumulation, oxidative stress resistance, thermal stress resistance) as well as the molecular signaling pathways involved. The effects of PME were examined in wildtype animals and mutants defective in the sirtuin-homologue SIR-2.1 (VC199) and the FOXO-homologue DAF-16 (CF1038). PME possesses antioxidative effects in vivo and increases oxidative stress resistance of the nematodes. While the accumulation of lipofuscin is only slightly decreased, PME causes a significant elongation (18.6%) of mean life span. DAF-16 is essential for the reduction of thermally induced ROS accumulation, while the resistance against paraquat-induced oxidative stress is dependent on SIR-2.1. For the extension of the life span, both DAF-16 and SIR-2.1 are needed. We demonstrate that PME exerts protective effects in C. elegans via modulation of distinct intracellular pathways.

scholarly journals Monascus-Fermented Dioscorea Enhances Oxidative Stress Resistance via DAF-16/FOXO in Caenorhabditis elegans

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e39515 ◽  
Author(s):  
Yeu-Ching Shi ◽  
Chan-Wei Yu ◽  
Vivian Hsiu-Chuan Liao ◽  
Tzu-Ming Pan
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Stress Resistance ◽  
Oxidative Stress Resistance

scholarly journals Leaf extract of Caesalpinia mimosoides enhances oxidative stress resistance and prolongs lifespan in Caenorhabditis elegans

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Panthakarn Rangsinth ◽  
Anchalee Prasansuklab ◽  
Chatrawee Duangjan ◽  
Xiaojie Gu ◽  
Krai Meemon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Stress Resistance ◽  
Leaf Extract ◽  
Oxidative Stress Resistance

scholarly journals Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast

FEBS Letters ◽  
2006 ◽  
Vol 580 (7) ◽  
pp. 1903-1907 ◽  
Author(s):  
An M. Aerts ◽  
Isabelle E.J.A. François ◽  
Leen Bammens ◽  
Bruno P.A. Cammue ◽  
Bart Smets ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Life Span ◽  
Stress Resistance ◽  
Plant Defensin ◽  
Oxidative Stress Resistance ◽  
Chronological Life Span

scholarly journals Correction: A Novel Role for the SMG-1 Kinase in Lifespan and Oxidative Stress Resistance in Caenorhabditis elegans

PLoS ONE ◽  
2009 ◽  
Vol 4 (1) ◽  
Author(s):  
Ingrid Masse ◽  
Laurent Molin ◽  
Laurent Mouchiroud ◽  
Philippe Vanhems ◽  
Francesca Palladino ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Stress Resistance ◽  
Oxidative Stress Resistance ◽  
And Oxidative Stress

scholarly journals Arginine methylation of SKN-1 promotes oxidative stress resistance in Caenorhabditis elegans

Redox Biology ◽  
2019 ◽  
Vol 21 ◽  
pp. 101111 ◽  
Author(s):  
Hongyuan Li ◽  
Liangping Su ◽  
Xin Su ◽  
Xin Liu ◽  
Dan Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caenorhabditis Elegans ◽  
Stress Resistance ◽  
Arginine Methylation ◽  
Oxidative Stress Resistance
Sign in / Sign up

Export Citation Format

Share Document