Malignant histiocytosis with a Langerhans cell subtype: A report on the diagnostic and therapeutic challenge

2021 ◽  
Vol 92 ◽  
pp. 102623
Author(s):  
Amel Kime ◽  
Claire Bréal ◽  
Anne-Ségolène Cottereau ◽  
Chloe Friedrich ◽  
Justine Decroocq ◽  
...  
Keyword(s):  
Langerhans Cell ◽  
Malignant Histiocytosis ◽  
Therapeutic Challenge ◽  
Cell Subtype ◽  
Subtype A

Fulminant Multisystem Non–Langerhans Cell Histiocytic Proliferation With Hemophagocytosis

2005 ◽  
Vol 129 (2) ◽  
pp. e39-e43 ◽  
Author(s):  
R. Nagarjun Rao ◽  
Chung-che Chang ◽  
Nevin Uysal ◽  
Kenneth Presberg ◽  
Vinod B. Shidham ◽  
...  
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Clinical Course ◽  
Langerhans Cell ◽  
Variant Form ◽  
Malignant Histiocytosis ◽  
Unique Case ◽  
Multiple Organs ◽  
Biopsy Specimens ◽  
Extensive Involvement ◽  
Erdheim Chester

Abstract Hemophagocytosis (HP), a feature seen in malignant histiocytosis and infection- and lymphoma-associated disorders, has not been previously emphasized in Erdheim-Chester disease (ECD). Generally, ECD is recognized as a rare, systemic, non–Langerhans cell histiocytosis with a variable clinical course. Herein, we describe a unique case of multisystem non–Langerhans cell histiocytic proliferation with a fulminant clinical course (death occurred within 3 months of presentation) that showed prominent HP and extensive involvement of multiple organs, including the lungs, resulting in respiratory failure. Hemophagocytosis led to severe anemia that required transfusion and thrombocytopenia. Antemortem lung and bone marrow biopsy specimens revealed involvement by a histiocytic infiltrate with features highly suggestive of ECD and HP. Furthermore, the autopsy documented the presence of HP and the histiocytic infiltrate in multiple other organs. This case is best categorized as a variant form of ECD. Recognizing this variant has the following important implications: (1) HP may be a marker for fulminant clinical course in ECD, (2) the presence of HP does not exclude a diagnosis of ECD, and (3) ECD should be considered in the differential diagnosis of HP.

scholarly journals Intracranial Tumorous Lesion as the First Manifestation of Langerhans Cell Histiocytosis: A Diagnostic and Therapeutic Challenge - Case Report

2017 ◽  
Vol 07 (01) ◽  
Author(s):  
Jolanta Florczak Wyspianska ◽  
MichaAA Owecki ◽  
MaAAgorzata Rzymkowska ◽  
Halina Batura Gabryel ◽  
Wojciech Kozubski
Keyword(s):  
Case Report ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Therapeutic Challenge ◽  
Tumorous Lesion

scholarly journals Langerhans cell tropism of human immunodeficiency virus type 1 subtype A through F isolates derived from different transmission groups.

1997 ◽  
Vol 71 (10) ◽  
pp. 8008-8013 ◽  
Author(s):  
M T Dittmar ◽  
G Simmons ◽  
S Hibbitts ◽  
M O'Hare ◽  
S Louisirirotchanakul ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Langerhans Cell ◽  
Cell Tropism ◽  
Immunodeficiency Virus ◽  
Subtype A

scholarly journals Comprehensive Immune Profiling of Lung Adenocarcinomas Reveals Four Immunosubtypes with Plasma Cell Subtype a Negative Indicator

2016 ◽  
Vol 4 (3) ◽  
pp. 234-247 ◽  
Author(s):  
Yutaka Kurebayashi ◽  
Katsura Emoto ◽  
Yuichiro Hayashi ◽  
Ikuo Kamiyama ◽  
Takashi Ohtsuka ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Cell Subtype ◽  
Subtype A ◽  
Lung Adenocarcinomas ◽  
Immune Profiling

Thyroid involvement by malignant histiocytosis of Langerhans' cell type

1996 ◽  
Vol 45 (3) ◽  
pp. 357-363 ◽  
Author(s):  
Shinji Kitahama ◽  
Makoto Iitaka ◽  
Tadashi Shimizu ◽  
Naoki Serizawa ◽  
Nobuhiko Fukasawa ◽  
...  
Keyword(s):  
Langerhans Cell ◽  
Cell Type ◽  
Malignant Histiocytosis

scholarly journals Prolymphocytic leukaemia of B- and T-cell subtype: a state-of-the-art paper

2008 ◽  
Vol 80 (6) ◽  
pp. 469-476 ◽  
Author(s):  
M. Dungarwalla ◽  
E. Matutes ◽  
C. E. Dearden
Keyword(s):  
T Cell ◽  
State Of The Art ◽  
Cell Subtype ◽  
Prolymphocytic Leukaemia ◽  
Subtype A

scholarly journals A Rare Case of Erdheim-Chester Disease (Non-Langerhans Cell Histiocytosis) with Concurrent Langerhans Cell Histiocytosis: A Diagnostic and Therapeutic Challenge

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Hamza Hashmi ◽  
Drew Murray ◽  
John Greenwell ◽  
Marwan Shaikh ◽  
Soumit Basu ◽  
...  
Keyword(s):  
Interferon Alpha ◽  
Langerhans Cell Histiocytosis ◽  
Rare Case ◽  
Langerhans Cell ◽  
Braf V600e ◽  
Therapeutic Challenge ◽  
Erdheim Chester Disease ◽  
Organ Systems ◽  
Erdheim Chester ◽  
Chester Disease

Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocyte disorder most commonly characterized by multifocal osteosclerotic lesions of the long bones demonstrating sheets of foamy histiocyte infiltrates on biopsy with or without histiocytic infiltration of extraskeletal tissues. ECD can be difficult to diagnose since it is a very rare disease that can affect many organ systems. Diagnosis is based on the pathologic evaluation of involved tissue interpreted within the clinical context. Patients who have the BRAF V600E mutation are treated first line with vemurafenib. For those without the mutation with symptomatic ECD, conventional or PEGylated interferon alpha is recommended. For patients who are either intolerant or nonresponsive to interferon alpha, systemic chemotherapy with or without corticosteroids can be used. We present a rare case of Erdheim-Chester disease with concurrent Langerhans cell histiocytosis which occurs in only one fifth of the cases and often presents as a diagnostic and therapeutic challenge.

Langerhans cell histiocytosis and thyroid carcinoma

1998 ◽  
Vol 138 (5) ◽  
pp. 909-910 ◽  
Author(s):  
Marzano ◽  
Gasparini ◽  
Grammatica ◽  
De Juli ◽  
Caputo
Keyword(s):  
Thyroid Carcinoma ◽  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell

Cytogenetic abnormalities in PHA-stimulated lymphocytes from patients with Langerhans cell histiocytosis

2000 ◽  
Vol 111 (1) ◽  
pp. 258-262 ◽  
Author(s):  
Susi Scappaticci ◽  
Cesare Danesino ◽  
Elena Rossi ◽  
Catherine Klersy ◽  
Gian Mario Fiori ◽  
...  
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Langerhans Cell ◽  
Cytogenetic Abnormalities
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