Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock

2005 ◽  
Vol 70 (4) ◽  
pp. 535-544 ◽  
Author(s):  
Jialiang Hu ◽  
Philippe E. Van den Steen ◽  
Chris Dillen ◽  
Ghislain Opdenakker
Keyword(s):  
Matrix Metalloproteinase ◽  
Endotoxin Shock ◽  
Matrix Metalloproteinase 9 ◽  
Gelatinase B ◽  
Neutrophil Collagenase ◽  
Metalloproteinase 9

scholarly journals Inhibition of Neutrophil Collagenase/MMP-8 and Gelatinase B/MMP-9 and Protection against Endotoxin Shock

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Zheng Qiu ◽  
Jianghai Chen ◽  
Hanmei Xu ◽  
Philippe E. Van den Steen ◽  
Ghislain Opdenakker ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Time Window ◽  
Survival Rates ◽  
Endotoxin Shock ◽  
Gelatinase B ◽  
Rapid Release ◽  
Extracellular Matrix Components ◽  
Neutrophil Collagenase ◽  
Life Threatening ◽  
Metalloproteinase 9

Endotoxin shock is a life-threatening disorder, associated with the rapid release of neutrophil enzymes, including neutrophil collagenase/matrix metalloproteinase-8 (MMP-8) and gelatinase B/matrix metalloproteinase-9 (MMP-9). After activation, these enzymes cleave extracellular matrix components and cytokines and thus may contribute to shock syndrome development. MMP inhibitors have been suggested as immunotherapy of endotoxin shock. However, little is known about the therapeutic time window of MMP inhibition. Here, a sublethal endotoxin shock mouse model was used to evaluate the effect of an MMP inhibiting peptide (P2) after intravenous or intraperitoneal injection and to study the time window between LPS and inhibitor injections. With the use of a specific ELISA the plasma P2 concentrations were monitored. Whereas we corroborated the treatment strategy of MMP targeting in endotoxin shock with a new inhibitor, we also demonstrated that the time window, within which effective MMP inhibition increased the survival rates, is rather limited.

Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritis

2006 ◽  
Vol 8 (6) ◽  
pp. 1434-1439 ◽  
Author(s):  
Ann-Marie Calander ◽  
Sofie Starckx ◽  
Ghislain Opdenakker ◽  
Philip Bergin ◽  
Marianne Quiding-Järbrink ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Matrix Metalloproteinase ◽  
Septic Arthritis ◽  
Matrix Metalloproteinase 9 ◽  
Gelatinase B ◽  
Metalloproteinase 9

scholarly journals Gelatinase B/Matrix Metalloproteinase-9 as Innate Immune Effector Molecule in Achalasia

2018 ◽  
Vol 9 (11) ◽  
pp. e208 ◽  
Author(s):  
Janette Furuzawa-Carballeda ◽  
Lise Boon ◽  
Gonzalo Torres-Villalobos ◽  
Fernanda Romero-Hernández ◽  
Estefania Ugarte-Berzal ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Innate Immune ◽  
Gelatinase B ◽  
Immune Effector ◽  
Effector Molecule ◽  
Innate Immune Effector ◽  
Metalloproteinase 9

Meprins process matrix metalloproteinase-9 (MMP-9)/gelatinase B and enhance the activation kinetics by MMP-3

FEBS Letters ◽  
2012 ◽  
Vol 586 (24) ◽  
pp. 4264-4269 ◽  
Author(s):  
Nathalie Geurts ◽  
Christoph Becker-Pauly ◽  
Erik Martens ◽  
Paul Proost ◽  
Philippe E. Van den Steen ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Activation Kinetics ◽  
Gelatinase B ◽  
Metalloproteinase 9

scholarly journals Insights into the Structure and Domain Flexibility of Full-Length Pro-Matrix Metalloproteinase-9/Gelatinase B

Structure ◽  
2007 ◽  
Vol 15 (10) ◽  
pp. 1227-1236 ◽  
Author(s):  
Gabriel Rosenblum ◽  
Philippe E. Van den Steen ◽  
Sidney R. Cohen ◽  
J. Günter Grossmann ◽  
Jessica Frenkel ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Full Length ◽  
Gelatinase B ◽  
Metalloproteinase 9

Expression of matrix metalloproteinase-9 (gelatinase B) in gouty arthritis and stimulation of MMP-9 by urate crystals in macrophages

2003 ◽  
Vol 89 (4) ◽  
pp. 791-799 ◽  
Author(s):  
Ming-Shium Hsieh ◽  
Hsin-Chiu Ho ◽  
Der-Tsay Chou ◽  
Shiann Pan ◽  
Yu-Chih Liang ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Gouty Arthritis ◽  
Matrix Metalloproteinase 9 ◽  
Gelatinase B ◽  
Metalloproteinase 9 ◽  
Urate Crystals ◽  
Stimulation Of
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