Kupffer cell inactivation by carbon monoxide bound to red blood cells preserves hepatic cytochrome P450 via anti-oxidant and anti-inflammatory effects exerted through the HMGB1/TLR-4 pathway during resuscitation from hemorrhagic shock

2015 ◽  
Vol 97 (3) ◽  
pp. 310-319 ◽  
Author(s):  
Shigeru Ogaki ◽  
Kazuaki Taguchi ◽  
Hitoshi Maeda ◽  
Hiroshi Watanabe ◽  
Yu Ishima ◽  
...  
Shock ◽  
2009 ◽  
Vol 31 (5) ◽  
pp. 507-514 ◽  
Author(s):  
Hiromi Sakai ◽  
Hirohisa Horinouchi ◽  
Eishun Tsuchida ◽  
Koichi Kobayashi

2004 ◽  
Vol 5 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Sergey B. Zaets ◽  
Tamara L. Berezina ◽  
Da-Zhong Xu ◽  
Qi Lu ◽  
David Cohen ◽  
...  

Blood ◽  
1972 ◽  
Vol 40 (2) ◽  
pp. 257-260 ◽  
Author(s):  
Stephen A. Landaw

Abstract Long-term recovery of 14C-labeled carbon monoxide (14CO) from labeled, transfused red blood cells (RBC) was studied in buffalo rats. Donor RBC (labeled with 14C-2-glycine) were transfused into host rats, and the 14CO formed from degradation of labeled hemoglobin heme was collected over the next 110+ days. The heme-equivalent 14CO recovery in 13 animals averaged 102.1 ± 2.1% (mean ± SE) of activity in hemoglobin heme of donor RBC. This confirms that heme of circulating RBC destroyed by random hemolysis and senescence is quantitatively converted to CO.


Blood ◽  
1996 ◽  
Vol 87 (2) ◽  
pp. 762-770 ◽  
Author(s):  
R Hume ◽  
A Burchell ◽  
BB Allan ◽  
CR Wolf ◽  
RW Kelly ◽  
...  

Recently, using immunohistochemical methods, we surprisingly found that endoplasmic reticulum glucose-6-phosphatase is present in human embryonic and fetal red blood cells (RBCs) but not in adult RBCs. The fact that an endoplasmic reticulum enzyme, whose major site of expression in adults is the liver, is present in human embryonic and fetal RBCs, particularly nucleated cells, indicated that it would be sensible to determine whether these cells also contain other endoplasmic reticulum enzyme systems normally found in adult liver. Therefore, we have studied the expression of other endoplasmic reticulum proteins and found that human embryonic and fetal RBC precursors contain other protein components of the glucose-6- phosphatase system, ie, the phosphate and glucose transport proteins as well as other enzymes (eg, uridine diphosphate- glucuronosyltransferases, cytochrome P450 isozymes, nicotinamide adenine dinucleotide phosphate cytochrome P450 oxidoreductase, and prostaglandin H synthase). In addition, we also found the predominantly cytosolic markers 15-hydroxyprostaglandin dehydrogenase, prostaglandins PGE2 and 13,14-dihydro-15-keto-PGE2. The expression of key enzymes that control glucose production, detoxification of endobiotics and xenobiotics, and the regulation of prostaglandin levels in embryonic and early fetal RBCs means that these cells may have an important role in protecting the developing conceptus before it establishes an efficient circulation and before all tissues fully express their normal complement of these enzymes.


2015 ◽  
Vol 78 ◽  
pp. S26-S30 ◽  
Author(s):  
Geir A. Sunde ◽  
Bjarne Vikenes ◽  
Geir Strandenes ◽  
Kjell-Christian Flo ◽  
Tor A. Hervig ◽  
...  

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