A pH-responsive cyclodextrin-based hybrid nanosystem as a nonviral vector for gene delivery

Biomaterials ◽  
2013 ◽  
Vol 34 (16) ◽  
pp. 4159-4172 ◽  
Author(s):  
Huaping Chen ◽  
Xueping Liu ◽  
Yin Dou ◽  
Binfeng He ◽  
Li Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Nonviral Vector ◽  
Ph Responsive ◽  
Hybrid Nanosystem

scholarly journals In Vitro Gene Delivery Mediated by Asialofetuin-Appended Cationic Liposomes Associated with γ-Cyclodextrin into Hepatocytes

2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Keiichi Motoyama ◽  
Yoshihiro Nakashima ◽  
Yukihiko Aramaki ◽  
Fumitoshi Hirayama ◽  
Kaneto Uekama ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Gene Delivery ◽  
Plasmid Dna ◽  
Transfection Efficiency ◽  
Cationic Liposomes ◽  
Nonviral Vector ◽  
Liposomal Membrane ◽  
Transfer Activity ◽  
Potential Use

The purpose of this study is to evaluate in vitro gene delivery mediated by asialofetuin-appended cationic liposomes (AF-liposomes) associating cyclodextrins (CyD/AF-liposomes) as a hepatocyte-selective nonviral vector. Of various CyDs, AF-liposomes associated with plasmid DNA (pDNA) and γ-cyclodextrin (γ-CyD) (pDNA/γ-CyD/AF-liposomes) showed the highest gene transfer activity in HepG2 cells without any significant cytotoxicity. In addition, γ-CyD enhanced the encapsulation ratio of pDNA with AF-liposomes, and also increased gene transfer activity as the entrapment ratio of pDNA into AF-liposomes was increased. γ-CyD stabilized the liposomal membrane of AF-liposomes and inhibited the release of calcein from AF-liposomes. The stabilizing effect of γ-CyD may be, at least in part, involved in the enhancing gene transfer activity of pDNA/γ-CyD/AF-liposomes. Therefore, these results suggest the potential use of γ-CyD for an enhancer of transfection efficiency of AF-liposomes.

scholarly journals BMP2 gene delivery to bone mesenchymal stem cell by chitosan-g-PEI nonviral vector

2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Jianhui Yue ◽  
Jun Wu ◽  
Di Liu ◽  
Xiaoli Zhao ◽  
William W Lu
Keyword(s):  
Stem Cell ◽  
Gene Delivery ◽  
Mesenchymal Stem Cell ◽  
Nonviral Vector

In Vivo-Targeted Gene Delivery Using Antibody-Based Nonviral Vector

2002 ◽  
Vol 13 (9) ◽  
pp. 1101-1114 ◽  
Author(s):  
Olivier Déas ◽  
Eric Angevin ◽  
Claire Cherbonnier ◽  
Anna Senik ◽  
Bernard Charpentier ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Nonviral Vector ◽  
Targeted Gene Delivery

pH-Responsive Degradable Dextran-Quantum Dot Nanohybrids for Enhanced Gene Delivery

2019 ◽  
Vol 11 (38) ◽  
pp. 34707-34716 ◽  
Author(s):  
Yanjun Liu ◽  
Nana Zhao ◽  
Fu-Jian Xu
Keyword(s):  
Gene Delivery ◽  
Quantum Dot ◽  
Ph Responsive
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