scholarly journals The surface coating of iron oxide nanoparticles drives their intracellular trafficking and degradation in endolysosomes differently depending on the cell type

Biomaterials ◽  
2022 ◽  
pp. 121365
Author(s):  
Yadileiny Portilla ◽  
Vladimir Mulens-Arias ◽  
Alberto Paradela ◽  
Antonio Ramos-Fernández ◽  
Sonia Pérez-Yagüe ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Surface Coating ◽  
Intracellular Trafficking ◽  
Oxide Nanoparticles ◽  
Cell Type

Evaluation of Surface-modified Superparamagnetic Iron Oxide Nanoparticles to Optimize Bacterial Immobilization for Bio-separation with the Least Inhibitory Effect on Microorganism Activity

2020 ◽  
Vol 10 (2) ◽  
pp. 166-174
Author(s):  
Mehdi Khoshneviszadeh ◽  
Sarah Zargarnezhad ◽  
Younes Ghasemi ◽  
Ahmad Gholami
Keyword(s):  
Iron Oxide ◽  
Amino Acid ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Surface Coating ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Surface Charges ◽  
Surface Modified

Background: Magnetic cell immobilization has been introduced as a novel, facile and highly efficient approach for cell separation. A stable attachment between bacterial cell wall with superparamagnetic iron oxide nanoparticles (SPIONs) would enable the microorganisms to be affected by an outer magnetic field. At high concentrations, SPIONs produce reactive oxygen species in cytoplasm, which induce apoptosis or necrosis in microorganisms. Choosing a proper surface coating could cover the defects and increase the efficiency. Methods: In this study, asparagine, APTES, lipo-amino acid and PEG surface modified SPIONs was synthesized by co-precipitation method and characterized by FTIR, TEM, VSM, XRD, DLS techniques. Then, their protective effects against four Gram-positive and Gram-negative bacterial strains including Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were examined through microdilution broth and compared to naked SPION. Results: The evaluation of characterization results showed that functionalization of magnetic nanoparticles could change their MS value, size and surface charges. Also, the microbial analysis revealed that lipo-amino acid coated magnetic nanoparticles has the least adverse effect on microbial strain among tested SPIONs. Conclusion: This study showed lipo-amino acid could be considered as the most protective and even promotive surface coating, which is explained by its optimizing effect on cell penetration and negligible reductive effects on magnetic properties of SPIONs. lipo-amino acid coated magnetic nanoparticles could be used in microbial biotechnology and industrial microbiology.

scholarly journals The impact of species and cell type on the nanosafety profile of iron oxide nanoparticles in neural cells

2016 ◽  
Vol 14 (1) ◽  
Author(s):  
Freya Joris ◽  
Daniel Valdepérez ◽  
Beatriz Pelaz ◽  
Stefaan J. Soenen ◽  
Bella B. Manshian ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Neural Cells ◽  
Cell Type ◽  
The Impact

Magnetic leathers

RSC Advances ◽  
2016 ◽  
Vol 6 (8) ◽  
pp. 6496-6503 ◽  
Author(s):  
P. Thanikaivelan ◽  
R. Murali ◽  
K. Krishnaraj
Keyword(s):  
Iron Oxide ◽  
Energy Harvesting ◽  
Iron Oxide Nanoparticles ◽  
Surface Coating ◽  
Oxide Nanoparticles ◽  
Free Wall ◽  
Coating Technique ◽  
Advanced Applications

Thermo-physically stable magnetic leathers were prepared using iron oxide nanoparticles by a conventional surface coating technique for advanced applications such as adhesive-free wall covering and energy harvesting.

Dextran and PEG Coating Reduced Nanoparticle Toxicity to Cells

2012 ◽  
Author(s):  
Miao Yu ◽  
Alisa Morss Clyne
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Cell Mechanics ◽  
Surface Coating ◽  
Biomedical Applications ◽  
Oxide Nanoparticles ◽  
Oxygen Species ◽  
Cell Toxicity ◽  
Peg Coating

Iron oxide nanoparticles are of interest for drug delivery, since they can be targeted using a magnetic field. However, prior to using nanoparticles in vivo, they must be shown as relatively non-toxic to cells. We and others have shown that bare iron oxide nanoparticles are readily taken up by cells, where they catalyze production of highly toxic reactive oxygen species (ROS). This oxidative stress disrupts the cell cytoskeleton and alters cell mechanics. [1] Iron oxide nanoparticles under current development for in vivo biomedical applications are often coated with a polysaccharide (eg. dextran) or a polymer (eg. polyethylene glycol, PEG). Both the size and the surface coating of nanoparticle may play an important role in cell toxicity.

Synthesis and Characterization of Iron Oxide Nanoparticles

2014 ◽  
pp. 89-107 ◽  
Author(s):  
John M. Melnyczuk ◽  
Soubantika Palchoudhury
Keyword(s):  
Magnetic Properties ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Surface Coating ◽  
Good Control ◽  
Decomposition Methods ◽  
Great Promise ◽  
Oxide Nanoparticles ◽  
Co Precipitation

Iron oxide nanoparticles show great promise in bio-applications like drug delivery, magnetic resonance imaging, and hyperthermia. This is because the size of these magnetic nanoparticles is comparable to biomolecules and the particles can be removed via normal iron metabolic pathways. These nanoparticles are also attractive for industrial separations and catalysis because they can be magnetically recovered. However, the size, morphology, and surface coating of the iron oxide nanoparticles greatly affect their magnetic properties and biocompatibility. Therefore, nanoparticles with tunable characteristics are desirable. This chapter elaborates the synthesis techniques for the formation of iron oxide nanoparticles with good control over reproducibility, surface and magnetic properties, and morphology. The well-known co-precipitation and thermal decomposition methods are detailed in this chapter. The surface modification routes and characterization of these nanoparticles are also discussed. The chapter will be particularly useful for engineering/science graduate students and/or faculty interested in synthesizing iron oxide nanoparticles for specific research applications.

Assembly of polyethylenimine-functionalized iron oxide nanoparticles as agents for DNA transfection with magnetofection technique

2014 ◽  
Vol 2 (45) ◽  
pp. 7936-7944 ◽  
Author(s):  
Lei Zhang ◽  
Yecheng Li ◽  
Jimmy C. Yu ◽  
Ying Ying Chen ◽  
King Ming Chan
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Intracellular Trafficking ◽  
Oxide Nanoparticles ◽  
Dna Transfection ◽  
Dna Carriers

In this work two PEI-functionalized magnetic DNA carriers were prepared for DNA transfection, and the intracellular trafficking of magnetofectins was studied.

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