Design, synthesis, and biological evaluation of hydroxamic acid-substituted 2,4-diaryl aminopyrimidines as potent EGFRT790M/L858R inhibitors for the treatment of NSCLC

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.105045 ◽

2021 ◽

pp. 105045

Author(s):

Lixue Chen ◽

Yunhao Zhang ◽

Changyuan Wang ◽

Zeyao Tang ◽

Qiang Meng ◽

...

Keyword(s):

Hydroxamic Acid ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Pyrazoline-Based Hydroxamic Acid Derivatives as Aminopeptidase N (APN) Inhibitors

ChemMedChem ◽

10.1002/cmdc.201700690 ◽

2018 ◽

Vol 13 (5) ◽

pp. 431-436 ◽

Author(s):

Jiangying Cao ◽

Jie Zang ◽

Chunhua Ma ◽

Xiaoguang Li ◽

Jinning Hou ◽

...

Keyword(s):

Hydroxamic Acid ◽

Biological Evaluation ◽

Aminopeptidase N ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hydroxamic Acid Derivatives

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Design, Synthesis, and Biological Evaluation of Vanillin Hydroxamic Acid Derivatives as Novel Peptide Deformylase Inhibitors

Current Computer - Aided Drug Design ◽

10.2174/1573409913666170613074601 ◽

2018 ◽

Vol 14 (1) ◽

pp. 95-101 ◽

Author(s):

Jian Gao ◽

Shengzhi Qiu ◽

Li Liang ◽

Zhixiang Hao ◽

Qianqian Zhou ◽

...

Keyword(s):

Hydroxamic Acid ◽

Biological Evaluation ◽

Peptide Deformylase ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hydroxamic Acid Derivatives

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Design, synthesis and biological evaluation of novel hydroxamic acid based histone deacetylase 6 selective inhibitors bearing phenylpyrazol scaffold as surface recognition motif

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2017.08.029 ◽

2018 ◽

Vol 26 (8) ◽

pp. 1418-1425 ◽

Author(s):

Jinyu Yang ◽

Gaoliang Cheng ◽

Qihao Xu ◽

Shenglin Luan ◽

Shuxiang Wang ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Biological Evaluation ◽

Histone Deacetylase 6 ◽

Selective Inhibitors ◽

Design Synthesis ◽

Recognition Motif ◽

Surface Recognition ◽

Synthesis And Biological Evaluation

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Design, Synthesis and Biological Evaluation of Hydroxamic Acid Derivatives as Potential High Density Lipoprotein (HDL) Receptor CLA-1 Up-Regulating Agents

Molecules ◽

10.3390/molecules16119178 ◽

2011 ◽

Vol 16 (11) ◽

pp. 9178-9193 ◽

Author(s):

Xiaofang Chen ◽

Li Wang ◽

Yu Du ◽

Yanbin Wu ◽

Xiaojian Jia ◽

...

Keyword(s):

High Density Lipoprotein ◽

Hydroxamic Acid ◽

Density Lipoprotein ◽

Biological Evaluation ◽

High Density ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hydroxamic Acid Derivatives

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Design, synthesis, and biological evaluation of indole-based hydroxamic acid derivatives as histone deacetylase inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113893 ◽

2022 ◽

Vol 227 ◽

pp. 113893

Author(s):

Bei-Er Jiang ◽

Jiaxin Hu ◽

Hao Liu ◽

Zhitao Liu ◽

Yu Wen ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hydroxamic Acid Derivatives

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Design, synthesis, and biological evaluation of target water‐soluble hydroxamic acid‐based HDACi derivatives as prodrugs

Chemical Biology & Drug Design ◽

10.1111/cbdd.13577 ◽

2019 ◽

Vol 94 (4) ◽

pp. 1760-1767 ◽

Author(s):

Jun Li ◽

Yedan Zhu ◽

Miaohong Xie ◽

Qian Zhang ◽

Wenting Du

Keyword(s):

Hydroxamic Acid ◽

Biological Evaluation ◽

Water Soluble ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of tyrosine-based hydroxamic acid analogs as novel histone deacetylases (HDACs) inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2011.06.046 ◽

2011 ◽

Vol 19 (15) ◽

pp. 4437-4444 ◽

Author(s):

Yingjie Zhang ◽

Jinhong Feng ◽

Chunxi Liu ◽

Hao Fang ◽

Wenfang Xu

Keyword(s):

Histone Deacetylases ◽

Hydroxamic Acid ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2014.08.030 ◽

2014 ◽

Vol 22 (21) ◽

pp. 6146-6155 ◽

Author(s):

Wei Yang ◽

Lixuan Li ◽

Xun Ji ◽

Xiaowei Wu ◽

Mingbo Su ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Histone Deacetylase Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hydroxamic Acid Derivatives

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Hybrids from Farnesylthiosalicylic Acid and Hydroxamic Acid as Dual Ras-Related Signaling and Histone Deacetylase (HDAC) Inhibitors: Design, Synthesis and Biological Evaluation

ChemMedChem ◽

10.1002/cmdc.201500019 ◽

2015 ◽

Vol 10 (6) ◽

pp. 971-976 ◽

Author(s):

Yong Ling ◽

Xuemin Wang ◽

Chenniu Wang ◽

Chenjun Xu ◽

Wei Zhang ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Hdac Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis and biological evaluation of thienopyrimidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2017.01.035 ◽

2017 ◽

Vol 128 ◽

pp. 293-299 ◽

Author(s):

Jiang Wang ◽

Mingbo Su ◽

Tingting Li ◽

Anhui Gao ◽

Wei Yang ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Hdac Inhibitors ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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