Design, synthesis, and biological evaluation of target water‐soluble hydroxamic acid‐based HDACi derivatives as prodrugs

Chemical Biology & Drug Design ◽

10.1111/cbdd.13577 ◽

2019 ◽

Vol 94 (4) ◽

pp. 1760-1767 ◽

Author(s):

Jun Li ◽

Yedan Zhu ◽

Miaohong Xie ◽

Qian Zhang ◽

Wenting Du

Keyword(s):

Hydroxamic Acid ◽

Biological Evaluation ◽

Water Soluble ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Abstract 284: Design, synthesis and biological evaluation of novel water-soluble salts of the antimitotic prodrugs 4-(3-alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides selectively bioactivated by cytochrome p450 1A1 in breast cancer cells

10.1158/1538-7445.am2021-284 ◽

2021 ◽

Author(s):

Vincent Ouellette ◽

Atziri Corin Chavez Alvarez ◽

Sébastien Fortin

Keyword(s):

Breast Cancer ◽

Cytochrome P450 ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Biological Evaluation ◽

Water Soluble ◽

Soluble Salts ◽

Cytochrome P450 1A1 ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Pyrazoline-Based Hydroxamic Acid Derivatives as Aminopeptidase N (APN) Inhibitors

ChemMedChem ◽

10.1002/cmdc.201700690 ◽

2018 ◽

Vol 13 (5) ◽

pp. 431-436 ◽

Author(s):

Jiangying Cao ◽

Jie Zang ◽

Chunhua Ma ◽

Xiaoguang Li ◽

Jinning Hou ◽

...

Keyword(s):

Hydroxamic Acid ◽

Biological Evaluation ◽

Aminopeptidase N ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hydroxamic Acid Derivatives

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Design, synthesis and biological evaluation of water-soluble per-O-methylated cyclodextrin-C60 conjugates as anti-influenza virus agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2018.01.040 ◽

2018 ◽

Vol 146 ◽

pp. 194-205 ◽

Author(s):

Xiaolei Zhu ◽

Sulong Xiao ◽

Demin Zhou ◽

Matthieu Sollogoub ◽

Yongmin Zhang

Keyword(s):

Influenza Virus ◽

Biological Evaluation ◽

Water Soluble ◽

Design Synthesis ◽

Methylated Cyclodextrin ◽

Synthesis And Biological Evaluation

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Design, Synthesis, and Biological Evaluation of Vanillin Hydroxamic Acid Derivatives as Novel Peptide Deformylase Inhibitors

Current Computer - Aided Drug Design ◽

10.2174/1573409913666170613074601 ◽

2018 ◽

Vol 14 (1) ◽

pp. 95-101 ◽

Author(s):

Jian Gao ◽

Shengzhi Qiu ◽

Li Liang ◽

Zhixiang Hao ◽

Qianqian Zhou ◽

...

Keyword(s):

Hydroxamic Acid ◽

Biological Evaluation ◽

Peptide Deformylase ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hydroxamic Acid Derivatives

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Design, synthesis and biological evaluation of novel hydroxamic acid based histone deacetylase 6 selective inhibitors bearing phenylpyrazol scaffold as surface recognition motif

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2017.08.029 ◽

2018 ◽

Vol 26 (8) ◽

pp. 1418-1425 ◽

Author(s):

Jinyu Yang ◽

Gaoliang Cheng ◽

Qihao Xu ◽

Shenglin Luan ◽

Shuxiang Wang ◽

...

Keyword(s):

Histone Deacetylase ◽

Hydroxamic Acid ◽

Biological Evaluation ◽

Histone Deacetylase 6 ◽

Selective Inhibitors ◽

Design Synthesis ◽

Recognition Motif ◽

Surface Recognition ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of novel water-soluble triptolide derivatives: Antineoplastic activity against imatinib-resistant CML cells bearing T315I mutant Bcr-Abl

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.01.052 ◽

2010 ◽

Vol 18 (5) ◽

pp. 1806-1815 ◽

Author(s):

Fang Xu ◽

Xianping Shi ◽

Shichang Li ◽

Jieshun Cui ◽

Zhongzheng Lu ◽

...

Keyword(s):

Biological Evaluation ◽

Water Soluble ◽

Antineoplastic Activity ◽

Design Synthesis ◽

Imatinib Resistant ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2016.01.007 ◽

2016 ◽

Vol 24 (5) ◽

pp. 938-956 ◽

Author(s):

Laxman Devkota ◽

Chen-Ming Lin ◽

Tracy E. Strecker ◽

Yifan Wang ◽

Justin K. Tidmore ◽

...

Keyword(s):

Biological Evaluation ◽

Water Soluble ◽

Vascular Disrupting Agents ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Vascular Disrupting

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Design, Synthesis and Biological Evaluation of Hydroxamic Acid Derivatives as Potential High Density Lipoprotein (HDL) Receptor CLA-1 Up-Regulating Agents

Molecules ◽

10.3390/molecules16119178 ◽

2011 ◽

Vol 16 (11) ◽

pp. 9178-9193 ◽

Author(s):

Xiaofang Chen ◽

Li Wang ◽

Yu Du ◽

Yanbin Wu ◽

Xiaojian Jia ◽

...

Keyword(s):

High Density Lipoprotein ◽

Hydroxamic Acid ◽

Density Lipoprotein ◽

Biological Evaluation ◽

High Density ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hydroxamic Acid Derivatives

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Design, synthesis, and biological evaluation of novel water-soluble N-mustards as potential anticancer agents

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.11.005 ◽

2011 ◽

Vol 19 (1) ◽

pp. 471-485 ◽

Author(s):

Naval Kapuriya ◽

Rajesh Kakadiya ◽

Huajin Dong ◽

Amit Kumar ◽

Pei-Chih Lee ◽

...

Keyword(s):

Anticancer Agents ◽

Biological Evaluation ◽

Water Soluble ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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Design, synthesis, and biological evaluation of hydroxamic acid-substituted 2,4-diaryl aminopyrimidines as potent EGFRT790M/L858R inhibitors for the treatment of NSCLC

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.105045 ◽

2021 ◽

pp. 105045

Author(s):

Lixue Chen ◽

Yunhao Zhang ◽

Changyuan Wang ◽

Zeyao Tang ◽

Qiang Meng ◽

...

Keyword(s):

Hydroxamic Acid ◽

Biological Evaluation ◽

Design Synthesis ◽

Synthesis And Biological Evaluation

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