Update on the role of autophagy in systemic lupus erythematosus: A novel therapeutic target

Background: Systemic Lupus Erythematosus (SLE) is a polysystem autoimmune disease that adversely affects human health. Various organs can be affected, including the kidney or brain. Traditional treatment methods for SLE primarily rely on glucocorticoids and immunosuppressors. Unfortunately, these therapeutic agents cannot prevent a high recurrence rate after SLE remission. Therefore, novel therapeutic targets are urgently required. Methods: A systematic search of the published literature regarding the abnormal structure and function of mitochondria in SLE and therapies targeting mitochondria was performed in several databases. Results: Accumulating evidence indicates that mitochondrial dysfunction plays important roles in the pathogenesis of SLE, including influencing mitochondrial DNA damage, mitochondrial dynamics change, abnormal mitochondrial biogenesis and energy metabolism, mitophagy, oxidative stress, inflammatory reactions, apoptosis and NETosis. Further investigation of mitochondrial pathophysiological roles will result in further clarification of SLE. Specific lupus-induced organ damage also exhibits characteristic mitochondrial changes. Conclusion: This review aimed to summarize the current research on the role of mitochondrial dysfunction in SLE, which will necessarily provide potential novel therapeutic targets for SLE.

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Faculty Opinions recommendation of The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutic target.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735334002.793576805 ◽

2020 ◽

Author(s):

Tak Mao Chan ◽

Susan Yung

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Therapeutic Target ◽

Systemic Lupus

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THU0311 IL3R-Alpha as A Novel Therapeutic Target in Systemic Lupus Erythematosus

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2016-eular.2210 ◽

2016 ◽

Vol 75 (Suppl 2) ◽

pp. 300.1-300

Author(s):

S. Oon ◽

H. Huynh ◽

T.Y. Tai ◽

M. Ng ◽

K. Monaghan ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Therapeutic Target ◽

Systemic Lupus ◽

Novel Therapeutic

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The role of IL-17 in systemic lupus erythematosus and its potential as a therapeutic target

Expert Review of Clinical Immunology ◽

10.1080/1744666x.2019.1593141 ◽

2019 ◽

Vol 15 (6) ◽

pp. 629-637 ◽

Cited By ~ 9

Author(s):

Tomohiro Koga ◽

Kunihiro Ichinose ◽

Atsushi Kawakami ◽

George C. Tsokos

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Therapeutic Target ◽

Systemic Lupus

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The role of microRNAs (MiR-125a and MiR-146a), RANTES, and IFN-γin systemic lupus erythematosus

10.36295/asro.2020.231382 ◽

2020 ◽

Vol 23 (13) ◽

Author(s):

Ikram khazal Qasim Al- hasso ◽

Aida Rashid Al- Derzi ◽

Ahmed Abdul-hassan Abbas ◽

Faiq I. Gorial ◽

Ahmed Sameer Alnuimi

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Systemic Lupus

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Acute interstitial nephritis and drug-induced systemic lupus erythematosus due to chlorthalidone and amiodarone: A case report

SAGE Open Medical Case Reports ◽

10.1177/2050313x20910029 ◽

2020 ◽

Vol 8 ◽

pp. 2050313X2091002 ◽

Cited By ~ 1

Author(s):

Umut Selamet ◽

Ramy M Hanna ◽

Anthony Sisk ◽

Lama Abdelnour ◽

Lena Ghobry ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Interstitial Nephritis ◽

Lupus Erythematosus ◽

Kidney Biopsy ◽

Kidney Injury ◽

Acute Interstitial Nephritis ◽

Systemic Lupus ◽

Drug Induced ◽

Systemic Manifestations

Drug-induced lupus erythematosus has features distinct from primary systemic lupus erythematosus. It can occur with a wide variety of agents that result in the generation of anti-histone or other types of antibodies. Systemic manifestations of drug-induced systemic lupus erythematosus may include renal dysfunction due to circulating immune complexes or due to other immune reactions to the culprit medication(s). Acute interstitial nephritis occurs due to DNA–drug or protein–drug complexes that trigger an allergic immune response. We report a patient who developed acute kidney injury, rash, and drug-induced systemic lupus diagnosed by serologies after starting chlorthalidone and amiodarone. A renal biopsy showed acute interstitial nephritis and not lupus-induced glomerulonephritis. It is important to note that systemic lupus erythematosus and acute interstitial nephritis can occur together, and this report highlights the role of the kidney biopsy in ascertaining the pathological diagnosis and outlining therapy in drug-induced lupus erythematosus.

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