scholarly journals The potential use of folate and its derivatives in treating psychiatric disorders: A systematic review

2022 ◽  
Vol 146 ◽  
pp. 112541
Author(s):  
Nelson Siu Kei Lam ◽  
Xin Xin Long ◽  
Xuegang Li ◽  
Mirette Saad ◽  
Florence Lim ◽  
...  
2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Yael D. Lewis ◽  
Lucy Gallop ◽  
Iain C. Campbell ◽  
Ulrike Schmidt

Abstract Background Most psychiatric disorders have their onset in childhood or adolescence, and if not fully treated have the potential for causing life-long psycho-social and physical sequelae. Effective psychotherapeutic and medication treatments exist, but a significant proportion of children and young people do not make a full recovery. Thus, novel, safe, brain-based alternatives or adjuncts to conventional treatments are needed. Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are non-invasive brain stimulation (NIBS) techniques which have shown clinical benefits in adult psychiatric conditions. However, in children and young people their efficacy is not well established. The objective of this study will be to systematically evaluate the evidence on clinical effects of NIBS in children and young people with psychiatric disorders, assessing disorder-specific symptoms, mood and neurocognitive functions. Methods We designed and registered a study protocol for a systematic review. We will include randomised and non-randomised controlled trials and observational studies (e.g. cohort, case-control, case series) assessing the effects of NIBS in children and young people (aged ≤ 24 years old) for psychiatric disorders. The primary outcome will be reduction of disorder-specific symptoms. Secondary outcomes will include effects on mood and cognition. A comprehensive search from database inception onwards will be conducted in MEDLINE, EMBASE and PsycINFO. Grey literature will be identified through searching multiple clinical trial registries. Two reviewers will independently screen all citations, full-text articles and abstract data. The methodological quality of the studies will be appraised using appropriate tools. We will provide a narrative synthesis of the evidence and according to heterogeneity will conduct an appropriate meta-analysis. Additional analyses will be conducted to explore the potential sources of heterogeneity. Discussion This systematic review will provide a broad and comprehensive evaluation of the evidence on clinical effects of NIBS in children and young people with psychiatric disorders. Our findings will be reported according to the PRISMA guidelines and will be of interest to multiple audiences (including patients, researchers, healthcare professionals and policy-makers). Results will be published in a peer-reviewed journal. Systematic review registration PROSPERO CRD42019158957


2021 ◽  
pp. 155005942199168
Author(s):  
Yuji Yamada ◽  
Takuma Inagawa ◽  
Naotsugu Hirabayashi ◽  
Tomiki Sumiyoshi

Background. Social cognition deficits are a core feature of psychiatric disorders, such as schizophrenia and mood disorder, and deteriorate the functionality of patients. However, no definite strategy has been established to treat social cognition (eg, emotion recognition) impairments in these illnesses. Here, we provide a systematic review of the literature regarding transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) for the treatment of social cognition deficits in individuals with psychiatric disorders. Methods. A literature search was conducted on English articles identified by PubMed, PsycINFO, and Web of Science databases, according to the guidelines of the PRISMA statement. We defined the inclusion criteria as follows: (1) randomized controlled trials (RCTs), (2) targeting patients with psychiatric disorders (included in F20-F39 of the 10th revision of the International Statistical Classification of Diseases and Related Health Problems [ICD-10]), (3) evaluating the effect of tDCS or rTMS, (4) reporting at least one standardized social cognition test. Results. Five papers (3 articles on tDCS and 2 articles on rTMS) met the inclusion criteria which deal with schizophrenia or depression. The significant effects of tDCS or rTMS targeting the left dorsolateral prefrontal cortex on the emotion recognition domain were reported in patients with schizophrenia or depression. In addition, rTMS on the right inferior parietal lobe was shown to ameliorate social perception impairments of schizophrenia. Conclusions. tDCS and rTMS may enhance some domains of social cognition in patients with psychiatric disorders. Further research is warranted to identify optimal parameters to maximize the cognitive benefits of these neuromodulation methods.


2021 ◽  
Vol 13 (1) ◽  
pp. 339
Author(s):  
Yoshimi Hasegawa ◽  
Siu-Kit Lau

A growing number of soundscape studies involving audiovisual factors have been conducted; however, their bimodal and interactive effects on indoor soundscape evaluations have not yet been thoroughly reviewed. The overarching goal of this systematic review was to develop the framework for designing sustainable indoor soundscapes by focusing on audiovisual factors and relations. A search for individual studies was conducted through three databases and search engines: Scopus, Web of Science, and PubMed. Based on the qualitative reviews of the selected thirty papers, a framework of indoor soundscape evaluation concerning visual and audiovisual indicators was proposed. Overall, the greenery factor was the most important visual variable, followed by the water features and moderating noise annoyance perceived by occupants in given indoor environments. The presence of visual information and sound-source visibility would moderate perceived noise annoyance and influence other audio-related perceptions. Furthermore, sound sources would impact multiple perceptual responses (audio, visual, cognitive, and emotional perceptions) related to the overall soundscape experiences when certain visual factors are interactively involved. The proposed framework highlights the potential use of the bimodality and interactivity of the audiovisual factors for designing indoor sound environments in more effective ways.


Aquaculture ◽  
2021 ◽  
Vol 540 ◽  
pp. 736747
Author(s):  
Eduardo B. Blödorn ◽  
William B. Domingues ◽  
Leandro S. Nunes ◽  
Eliza R. Komninou ◽  
Danillo Pinhal ◽  
...  

2019 ◽  
Vol 10 ◽  
Author(s):  
Saeed Ahmed ◽  
Ramya Bachu ◽  
Padma Kotapati ◽  
Mahwish Adnan ◽  
Rizwan Ahmed ◽  
...  

2018 ◽  
Vol 14 (1) ◽  
pp. 207-222 ◽  
Author(s):  
Harri Halonen ◽  
Jenna Nissinen ◽  
Heli Lehtiniemi ◽  
Tuula Salo ◽  
Pirkko Riipinen ◽  
...  

Background:A growing amount of evidence suggests that dental anxiety is associated with other psychiatric disorders and symptoms. A systematic review was conducted to critically evaluate the studies of comorbidity of dental anxiety with other specific phobias and other Axis I psychiatric disorders.Objective:The aim of the review was to explore how dental anxiety is associated with other psychiatric disorders and to estimate the level of comorbid symptoms in dental anxiety patients.Methods:The review was conducted and reported in accordance with the MOOSE statement. Data sources included PubMed, PsycInfo, Web of Science and Scopus.Results:The search produced 631 hits, of which 16 unique records fulfilled the inclusion criteria. The number of eligible papers was low. Study populations were heterogeneous including 6,486 participants, and a total of 25 tests and in few cases clinical interviews were used in the evaluation processes. The results enhanced the idea about the comorbidity between dental anxiety and other psychiatric disorders. The effect was found strong in several studies.Conclusion:Patients with a high level of dental anxiety are more prone to have a high level of comorbid phobias, depression, mood disorders and other psychiatric disorders and symptoms.


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