Simultaneous monitoring of sweat lactate content and sweat secretion rate by wearable remote biosensors

Adults with GH deficiency are known to exhibit reduced sweating. Whether sweating capacity is impacted in obese subjects with impaired GH secretion have not previously been investigated. The main objective was to investigate sweat secretion rate and the GH-IGF-I axis in obese subjects before and after weight loss. Sixteen severely obese women (BMI, 40.6 ± 1.1 kg/m2) were investigated before and after a diet-induced weight loss. Sixteen age-matched nonobese women served as controls. The obese subjects presented the characteristic decreased GH release, hyperinsulinaemia, increased FFA levels, and impaired insulin sensitivity, which all were normalised after diet-induced weight loss of 30 ± 5 kg. Sweat secretion rates were similar comparing obese and nonobese subjects (78 ± 10 versus 82 ± 9 mg/30 minutes) and sweat secretion did not change after a diet-induced weight loss in obese subjects. We conclude that although obese subjects have markedly reduced GH release and impaired IGF-I levels, sweat secretion rate is found to be normal.

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A COMPARISON OF TWO METHODS FOR MEASUREMENT OF ALDOSTERONE SECRETION RATE IN MAN

Acta Endocrinologica ◽

10.1530/acta.0.0530177 ◽

1966 ◽

Vol 53 (2) ◽

pp. 177-188 ◽

Cited By ~ 4

Author(s):

P. Lund-Johansen ◽

T. Thorsen ◽

K. F. Støa

Keyword(s):

Urinary Excretion ◽

Normal Subjects ◽

Secretion Rate ◽

Aldosterone Secretion ◽

Simple Method ◽

Mean Values ◽

Pathological Conditions ◽

Significant Difference ◽

Derivative Method ◽

The Mean

ABSTRACT A comparison has been made between (A), a relatively simple method for the measurement of aldosterone secretion rate, based on paper chromatography and direct densitometry of the aldosterone spot and (B) a more elaborate isotope derivative method. The mean secretion rate in 9 normal subjects was 112 ± 26 μg per 24 hours (method A) and 135 ± 35 μg per 24 hours (method B). The »secretion rate« in one adrenalectomized subject after the intravenous injection of 250 μg of aldosterone was 230 μg per 24 hours (method A) and 294 μg per 24 hours (method B). There was no significant difference in the mean values, and correlation between the two methods was good (r = 0.80). It is concluded that the densitometric method is suitable for clinical purposes as well as research, being more rapid and less expensive than the isotope derivative method. Method A also measures the urinary excretion of the aldosterone 3-oxo-conjugate, which is of interest in many pathological conditions. The densitometric method is obviously the less sensitive and a prerequisite for its use is an aldosterone secretion of 20—30 μg per 24 hours. Lower values are, however, rare in adults.

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CORTISOL SECRETION RATE DETERMINATION IN CHILDREN BY AN ISOTOPE DILUTION METHOD

Acta Endocrinologica ◽

10.1530/acta.0.045s016 ◽

1964 ◽

Vol 45 (3_Suppl) ◽

pp. S16-S17 ◽

Cited By ~ 5

Author(s):

J. Bertrand ◽

B. Laros ◽

B. Cautenet

Keyword(s):

Isotope Dilution ◽

Secretion Rate ◽

Isotope Dilution Method ◽

Dilution Method ◽

Cortisol Secretion

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DIE ZUSAMMENSETZUNG DER JODHALTIGEN VERBINDUNGEN UND IHRE BEZIEHUNG ZUM JODUMSATZ IN EUTHYREOTEN STRUMEN

Acta Endocrinologica ◽

10.1530/acta.0.0410584 ◽

1962 ◽

Vol 41 (4) ◽

pp. 584-594 ◽

Cited By ~ 2

Author(s):

Dankwart Reinwein ◽

Erich Klein

Keyword(s):

Column Chromatography ◽

Iodine Content ◽

High Plasma ◽

Secretion Rate ◽

Total Iodine ◽

Iodine Compound ◽

Hormonal Secretion ◽

Carrier Free ◽

Iodine Metabolism ◽

Diffuse Goiter

ABSTRACT The iodine metabolism was investigated in 29 patients with euthyroid non-endemic diffuse goiter. 1 to 14 days before thyroidectomy the patients received carrier-free 131I. The chemical iodine fractions (PBI, BEI and iodide) of the thyroid and the labelled iodine compound were analyzed by means of paper- and column chromatography. In one gland the total iodine content varied only by ± 19.6% of the average, the relative shares of PBI, BEI and iodide as well as that of the iodoamino acids being equal. Monoiodotyrosine, diiodotyrosine and thyroxine were found in the thyroid homogenate without hydrolysis. The homogenate after hydrolysis contained more iodotyrosines at the expense of iodothyronines than do normal glands. 17 goiters with normal 131I-uptake showed a high total iodine content (14.2 ± 5.0 mg) whilst 9 goiters with an increased 131I-uptake had low values (3.58 ± 0.6 mg). The opposite was found for the relative shares of BEI with the chromatographically isolated iodothyronines thyroxine, triiodothyronine and an unidentified iodine compound. Goiters with »high plasma PB131I« were characterized by a faster transfer of 131I into the more heavily iodinated compounds than is found in glands with a normal hormonal secretion rate. The highest values for the iodothyronines were found in goiters with increased 131I-uptake together with a high hormonal secretion rate. From this study it appears that the changes in the iodine-poor glands are due to a defective exo- or endogenous iodine supply. The observed alterations in iodine-rich glands are probably induced by a faulty iodine utilization characterized by an incomplete iodotyrosyl-coupling defect.

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IMITATION OF THE ADRENO-CORTICAL RESPONSE TO SURGERY BY INTRAVENOUS INFUSION OF SYNTHETIC HUMAN ACTH

Acta Endocrinologica ◽

10.1530/acta.0.0720075 ◽

1973 ◽

Vol 72 (1) ◽

pp. 75-80

Author(s):

Henrik Kehlet ◽

Christian Binder ◽

Christen Engbæk

Keyword(s):

Intravenous Infusion ◽

Time Course ◽

Cortical Response ◽

Secretion Rate ◽

Major Surgery ◽

Acth Secretion ◽

Dose Rates

ABSTRACT The concentration of plasma corticosteroids was followed during major surgery and during the infusion of synthetic human ACTH at dose rates varying from 2400 ng to 15 000 ng per hour. The results showed that the time course of plasma corticosteroids during major surgery was intermediate between that obtained during the infusion of 7500 and 15 000 ng synthetic human ACTH per hour. This gives an estimated ACTH secretion rate during major surgery of between 7500 ng and 15 000 ng per hour.

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EFFECT OF HEPARIN ON THE CORTICOSTERONE SECRETION RATE WITH A DESCRIPTION OF THE DOUBLE ISOTOPE METHOD USED

Acta Endocrinologica ◽

10.1530/acta.0.056s140 ◽

1967 ◽

Vol 56 (1_Suppl) ◽

pp. S140 ◽

Cited By ~ 4

Author(s):

A. F. Casparie ◽

Th. J. Benraad ◽

P. W. C. Kloppenborg ◽

C. L. H. Majoor

Keyword(s):

Secretion Rate ◽

Isotope Method ◽

Corticosterone Secretion ◽

Double Isotope

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ADRENAL 17-HYDROXYCORTICOSTEROID SECRETION IN THE DOG IN RESPONSE TO ETHANOL

Acta Endocrinologica ◽

10.1530/acta.0.0700736 ◽

1972 ◽

Vol 70 (4) ◽

pp. 736-740 ◽

Cited By ~ 6

Author(s):

T. Suzuki ◽

R. Higashi ◽

T. Hirose ◽

H. Ikeda ◽

K. Tamura

Keyword(s):

Venous Blood ◽

Secretion Rate ◽

Conscious Dogs ◽

Blood Samples ◽

Before And After

ABSTRACT Conscious dogs were infused intravenously with ethanol in doses of 0.7 and 1.0 g/kg. The adrenal venous blood samples were collected before and after the infusion of ethanol and analysed for 17-hydroxycorticosteroids (17-OHCS). After the infusion of 0.7 g/kg (subanaesthetic dose) of ethanol the adrenal 17-OHCS secretion rate showed either a slight increase or no change. After the infusion of 1.0 g/kg (anaesthetic dose) of ethanol the adrenal 17-OHCS secretion rate increased markedly and reached 1.21±0.15 (mean±sem) μg/kg/min, while it was 0.09±0.023 μg/kg/min before the infusion.

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