Sclerotherapy for low-flow vascular malformations of the head and neck: A systematic review of sclerosing agents

2016 ◽  
Vol 69 (3) ◽  
pp. 295-304 ◽  
Author(s):  
Sophie E.R. Horbach ◽  
Max M. Lokhorst ◽  
Peerooz Saeed ◽  
Claire M.F. de Goüyon Matignon de Pontouraude ◽  
Aniki Rothová ◽  
...  
2020 ◽  
pp. 159101992097251
Author(s):  
Khunsa Faiz ◽  
Stephanos Finitsis ◽  
Janice Linton ◽  
Jai Jai Shiva Shankar

Background Orbital and peri-orbital venolymphatic malformations (VLM) are low flow vascular malformations. Intralesional bleomycin is now commonly being used to treat such malformations. Objective The purpose of this systematic review is to synthesize evidence on the safety and efficacy of bleomycin/pingyangmycin sclerotherapy for the treatment of orbital and peri-orbital VLM. Methods We searched Medline, Embase, Scopus and Cochrane database for studies reporting outcomes of bleomycin/pingyangmycin sclerotherapy for orbital and peri-orbital VLM between 1974 to April 5th, 2019. Nine retrospective cohort studies enrolling 132 patients were included. Two reviewers independently screened and extracted data and assessed the risk of bias. Predefined outcome measures were subjective and objective reduction of the lesion and associated complications. Results Subjective reduction of the lesions was seen in 96.2% of the studies. Objective reduction of the lesion and symptomatic improvement were reported in 91.6 and 95% of the studies respectively. Non responders were 9.0%. Minor adverse events were reported in 18.1% of the studies. Major complications like pulmonary toxicity or pulmonary fibrosis was not encountered in any of the included studies. Quality of evidence was generally low. Conclusion Bleomycin/pingyangmycin sclerotherapy is very effective and relatively safe for the treatment of orbital and periorbital VLM and is not associated with any major side effects including pulmonary fibrosis. Limitations: The systematic review is limited mainly due to low quality of the included studies with retrospective design.


2019 ◽  
Vol 25 (6) ◽  
pp. 459-464 ◽  
Author(s):  
Anna Maria Ierardi ◽  
◽  
Giacomo Colletti ◽  
Pierpaolo Biondetti ◽  
Margherita Dessy ◽  
...  

2011 ◽  
Vol 268 (10) ◽  
pp. 1505-1511 ◽  
Author(s):  
Behfar Eivazi ◽  
Ayotunde J. Fasunla ◽  
Walter Hundt ◽  
Susanne Wiegand ◽  
Afshin Teymoortash

2021 ◽  
Vol 8 (4) ◽  
pp. 1234
Author(s):  
Manpreet Kaur ◽  
Parul Sachdeva ◽  
Rajan Syal ◽  
Savijot Singh

Background: Low flow vascular malformations are most common in the head and neck region. Only symptomatic malformations require treatment. Sclerotherapy followed by surgery was considered the gold standard treatment but in the head and neck region, it may produce cosmetic and physiological defects. In the present study, multiple injections of sclerotherapy with 3% sodium tetradecyl sulphate was used for the treatment of low flow vascular malformations.Methods: Twenty cases of low flow vascular malformations of the oral cavity who presented in the outpatient department of ESIC Model Hospital, Ludhiana from 2014-2016 were selected for the study. Only significantly sized (>4 cm) and easily accessible lesions were included. Staged sequential sclerotherapy with 3% STS under strict fluoroscopy control was used as the sole treatment.Results: A total of 20 patients were taken of which, 25% required three sessions, 65% five to six sessions each and 10% required eight sessions each. All patients showed good results with complete regression and no mucosal ulceration.Conclusions: Staged sequential sclerotherapy with 3% STS should be the treatment of choice in low flow vascular lesions involving mucosal and cutaneous structures of head and neck region especially anterior two-thirds of tongue, palate, gingiva, buccal mucosa and lips. Surgical removal may affect critical neurovascular structures and cause cosmetic deformity. So the removal is advisable in life-threatening conditions, lesions requiring general anaesthesia and single sitting removal.


2014 ◽  
Vol 52 (8) ◽  
pp. e67-e68
Author(s):  
Louise Dunphy ◽  
S. O’Connell ◽  
K. McMillan ◽  
A. Monaghan.

2021 ◽  
Vol 62 (6) ◽  
pp. e87
Author(s):  
Calver Pang ◽  
Nicholas Evans ◽  
Anthie Papadopoulou ◽  
Mohamed Khalifa ◽  
Janice Tsui ◽  
...  

2020 ◽  
Vol 65 (1) ◽  
pp. 41-47 ◽  
Author(s):  
Lucio De Maria ◽  
Paolo De Sanctis ◽  
Megha Tollefson ◽  
Samir Mardini ◽  
James A. Garrity ◽  
...  

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